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Can a diabetes drug replace surgery for a rare hormone disorder?

NCT ID NCT07361874

Recruiting now Disease control Sponsor: University of Texas Southwestern Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at two treatments for mild autonomous cortisol secretion (MACS), a condition where the body makes too much cortisol. Researchers want to see if removing the adrenal gland (surgery) or taking semaglutide (a weight-loss drug) better improves insulin resistance and other health measures. About 75 adults with MACS or similar health issues will take part over 26-30 weeks.

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Conditions

The condition(s) this trial relates to.

ACTH-independent Cushing syndrome Adrenal incidentaloma Cushing syndrome ectopic ACTH secretion syndrome Insulin Resistance Weight Loss

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AUTONOMOUS CORTISOL SECRETION (ACS) MILD AUTONOMOUS CORTISOL EXCESS MILD AUTONOMOUS CORTISOL SECRETION (MACS) SUBCLINICAL CUSHING'S

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • University of Texas Southwestern Medical Center

    RECRUITING

    Dallas, Texas, 75390, United States

    Contact Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

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