Drug showdown: which pill tames cortisol better?
NCT ID NCT07268222
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study compares two medications, metyrapone and osilodrostat, in 150 adults with mild autonomous cortisol secretion (MACS). Participants receive one of the drugs, surgery, or watchful waiting. The goal is to see which drug better lowers cortisol and improves related health issues like high blood pressure and blood sugar over 6 months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
metyrapone and osilodrostat (oral tablets)
What this could lead to
If successful, this trial could show which drug better controls cortisol levels and improves blood pressure, weight, and blood sugar in people with mild autonomous cortisol secretion.
What could go wrong
This is a relatively small Phase 4 trial, so results may not apply to everyone. Both drugs can cause side effects like nausea or low cortisol, and the study does not test a cure.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Laikon General Hospital
RECRUITINGAthens, Greece