New study tests which drug better tames cortisol excess

This study compares two medications, metyrapone and osilodrostat, to see which works better and has fewer side effects for people with mild autonomous cortisol secretion (MACS), a condition where the body makes too much cortisol. About 150 adults with adrenal adenomas or hyperplasia who are not having surgery will take one of the drugs for 6 months. Researchers will measure hormone levels, blood pressure, weight, blood sugar, and bone density to find the best treatment option.