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Triple-A syndrome

MONDO:0009279

Triple A syndrome is a very rare multisystem disease characterized by adrenal insufficiency with isolated glucocorticoid deficiency, achalasia, alacrima, autonomic dysfunction and neurodegeneration.

Also known as: 2A syndrome, 3A syndrome, 4A syndrome, AAA syndrome, Allgrove syndrome, Double A syndrome, achalasia-addisonianism-alacrima syndrome, adrenal insufficiency-achalasia-alacrima syndrome

4 clinical trials for this condition and its sub-types.

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Broader categories

Disease (680) Hereditary disease (176) Endocrine system disorder (72) Adrenocortical insufficiency (26) Syndromic disease (25) Human disease (14) Adrenal gland disorder (8) Chronic primary adrenal insufficiency (5) Autosomal recessive disease (4) Primary adrenal insufficiency (4)
Trials to join now! 1 Not yet recruiting 1 Not yet finished but already full! 1 Completed 1
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  • New imaging tracer could shed light on adrenal cholesterol

    Knowledge-focused Recruiting now

    This study tests a special radioactive tracer called [18F]FNP-59 to see if it can safely and clearly show cholesterol activity in the adrenal gland using PET scans. About 24 people will take part, including healthy volunteers and those with known adrenal problems. The goal is to …

    Phase: EARLY_PHASE1 • Sponsor: Benjamin Viglianti • Aim: Knowledge-focused

    Last updated Jun 27, 2026 08:02 UTC

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