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Triple-A syndrome

MONDO:0009279

Triple A syndrome is a very rare multisystem disease characterized by adrenal insufficiency with isolated glucocorticoid deficiency, achalasia, alacrima, autonomic dysfunction and neurodegeneration.

Also known as: 2A syndrome, 3A syndrome, 4A syndrome, AAA syndrome, Allgrove syndrome, Double A syndrome, achalasia-addisonianism-alacrima syndrome, adrenal insufficiency-achalasia-alacrima syndrome

4 clinical trials for this condition and its sub-types.

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Broader categories

Disease (680) Hereditary disease (176) Endocrine system disorder (72) Adrenocortical insufficiency (26) Syndromic disease (25) Human disease (14) Adrenal gland disorder (8) Chronic primary adrenal insufficiency (5) Autosomal recessive disease (4) Primary adrenal insufficiency (4)
Trials to join now! 1 Not yet recruiting 1 Not yet finished but already full! 1 Completed 1
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  • New device aims to stop aneurysm growth without open surgery

    Disease control Ongoing

    This study tests a new device called the Nectero EAST System in 46 people with abdominal aortic aneurysms (AAA). The goal is to see if it is safe and can stop the aneurysm from growing, reducing the need for major surgery. Participants receive the device through a catheter, and d…

    Phase: NA • Sponsor: Nectero Medical, Inc. • Aim: Disease control

    Last updated Jun 27, 2026 08:04 UTC

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