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Triple-A syndrome

MONDO:0009279

Triple A syndrome is a very rare multisystem disease characterized by adrenal insufficiency with isolated glucocorticoid deficiency, achalasia, alacrima, autonomic dysfunction and neurodegeneration.

Also known as: 2A syndrome, 3A syndrome, 4A syndrome, AAA syndrome, Allgrove syndrome, Double A syndrome, achalasia-addisonianism-alacrima syndrome, adrenal insufficiency-achalasia-alacrima syndrome

4 clinical trials for this condition and its sub-types.

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Broader categories

Disease (680) Hereditary disease (176) Endocrine system disorder (72) Adrenocortical insufficiency (26) Syndromic disease (25) Human disease (14) Adrenal gland disorder (8) Chronic primary adrenal insufficiency (5) Autosomal recessive disease (4) Primary adrenal insufficiency (4)
Trials to join now! 1 Not yet recruiting 1 Not yet finished but already full! 1 Completed 1
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  • New stent graft aims to fix aneurysms without major surgery

    Disease control Completed

    This study tested a special stent graft (E-liac) to treat bulges in the iliac artery (aneurysms) without open surgery. 71 patients received the device, sometimes combined with other aortic grafts. The main goal was to prevent aneurysm rupture and death. Researchers tracked succes…

    Sponsor: JOTEC GmbH • Aim: Disease control

    Last updated Jun 27, 2026 09:06 UTC

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