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Triple-A syndrome

MONDO:0009279

Triple A syndrome is a very rare multisystem disease characterized by adrenal insufficiency with isolated glucocorticoid deficiency, achalasia, alacrima, autonomic dysfunction and neurodegeneration.

Also known as: 2A syndrome, 3A syndrome, 4A syndrome, AAA syndrome, Allgrove syndrome, Double A syndrome, achalasia-addisonianism-alacrima syndrome, adrenal insufficiency-achalasia-alacrima syndrome

10 clinical trials for this condition and its sub-types.

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Broader categories

Disease (618) Hereditary disease (172) Endocrine system disorder (61) Syndromic disease (24) Adrenocortical insufficiency (23) Human disease (14) Adrenal gland disorder (8) Autosomal recessive disease (4) Chronic primary adrenal insufficiency (4) Primary adrenal insufficiency (3)
Trials to join now! 5 Not yet recruiting 1 Not yet finished but already full! 2 Completed 2
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  • Tiny trial to see if a dye helps adrenal surgery

    Knowledge-focused Not yet recruiting

    This study will look at 12 people having surgery to remove an adrenal gland (adrenalectomy) using robotic or laparoscopic methods. Some surgeries will use a green dye called Indocyanine Green (ICG) to help the surgeon see better, while others will not. The main goal is to track c…

    Sponsor: University of Roma La Sapienza • Aim: Knowledge-focused

    Last updated Jun 27, 2026 12:32 UTC

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