PNEUMONIA

This study looks at how well a 20-valent pneumococcal vaccine works against pneumonia in adults aged 65 and older who are hospitalized with the infection. Participants provide a urine sample and medical history, and researchers compare vaccination rates between those with vaccine…

This study looks at whether some children with mild pneumonia can recover without antibiotics. About 700 kids aged 6 months to 18 years who visit the emergency room with pneumonia but are well enough to go home will take part. Doctors will compare standard antibiotic treatment ag…

This study looks at whether children with medical complexity who have pneumonia can safely stop antibiotics earlier, based on when they become clinically stable. Researchers will enroll 50 patients aged 2-25 at Boston Children's Hospital. The goal is to reduce unnecessary antibio…

This study tests an experimental drug called AV-001 in people hospitalized with pneumonia caused by COVID-19 or other infections. About 120 participants will receive either the drug or a placebo alongside standard care. The goal is to see if AV-001 is safe and helps patients reco…

This study looks at whether adding a gentle brain stimulation technique (rTMS) to standard swallowing therapy can lower the chance of pneumonia in people who have trouble swallowing after a stroke. About 70 adults with moderate to severe swallowing issues will take part. The goal…

This study looks at whether using higher pressure (PEEP) during noninvasive breathing support can help people with pneumonia or ARDS avoid needing a breathing tube. About 700 adults who are already on a mask ventilator will be randomly assigned to receive either high or low press…

This study looks at whether low-intensity laser therapy can improve the immune response in children with Down syndrome who have pneumonia. Forty children will receive either laser therapy plus breathing exercises and standard medical care, or just breathing exercises and standard…

This large study tests various treatments for people hospitalized with pneumonia, including from COVID-19 and flu. The main goal is to see which treatments reduce the risk of death. Over 70,000 participants are involved, and the study compares multiple drugs to standard care.

This study tests whether a special blood filter (oXiris) works better than a standard filter (M100) for people with pneumonia who also develop acute kidney injury. About 60 adults will be enrolled to see which filter reduces inflammation and improves survival over 28 days. The go…

This study tests a new ventilator (INBENTUS VERSATILE) in 81 adults who need help breathing due to conditions like pneumonia, ARDS, or COPD. Participants will use the ventilator for 3 to 48 hours, and researchers will monitor for side effects and how well the machine works. The g…

This study checks how well standard ICU monitors measure blood flow and fluid needs in 30 adults on VA-ECMO, a machine that pumps and oxygenates blood outside the body. Researchers will compare three monitoring methods to see which works best during this special situation. The go…

This study checks if standard heart and blood flow monitors work correctly in patients on ECMO, a machine that adds oxygen to blood outside the body. Researchers will compare three monitoring methods in 30 adults on ECMO for severe lung failure. The goal is to improve how doctors…

This study looks at better ways to diagnose pneumonia in older adults (65+) who come to the emergency room. Researchers will test 250 patients and use new biomarkers to tell if pneumonia is bacterial, viral, or both. The goal is to create a clearer, more accurate diagnostic path …

This study is testing a device called Inflammacheck that measures certain chemicals in your breath to see if it can help doctors tell the difference between lung cancer, other lung diseases, and healthy lungs. About 140 adults will take part, including people with lung cancer, pn…

This study is testing a new ultrasound measurement called the Lung Sliding Index (LSI) to see if it can help doctors tell apart different lung diseases like COPD, pneumonia, and pneumothorax. Researchers will enroll 700 adults with various lung conditions and healthy volunteers t…

This study tests a new portable X-ray machine that takes moving images of the lungs at the bedside in the ICU. It aims to see if this technology can give doctors better information about lung function and blood flow compared to standard X-rays. About 230 adults with various lung …

This study tests whether improved oral hygiene combined with antibiotics can prevent pneumonia in people who have had a brain hemorrhage. About 440 adults with mild to moderate bleeding will be randomly assigned to receive either standard care or enhanced mouth care plus antibiot…

This study tests whether breathing high doses of nitric oxide gas can help critically ill patients recover from pneumonia. About 34 adults on breathing machines will receive either the gas or a placebo for 5 days. Researchers will monitor safety and check if more patients get bet…

This study compares a combination of two sedatives (propofol and ketamine) against propofol alone in elderly ICU patients who need a breathing tube. The goal is to see if the combo reduces dangerous drops in blood pressure. About 41 patients aged 65 and older with heart disease a…

This study tests a personalized approach to giving steroids to hospitalized adults with pneumonia. Instead of a standard dose, doctors will use a blood test (CRP) to decide the right amount and timing for each patient. The goal is to reduce steroid side effects while still contro…

This study tests whether adding a special breathing treatment called intrapulmonary percussive ventilation (IPV) to standard care helps pneumonia patients on ventilators recover faster. About 96 adults will be randomly assigned to receive either standard care alone or standard ca…

This study tests if exposure to bright blue light can reduce inflammation and organ damage in patients hospitalized with serious infections like pneumonia, infected joints, or abdominal infections. About 144 adults will be assigned to either blue light or standard hospital light …

This study looks at proteins in lung fluid from people with pneumonia to find patterns that might reveal what's causing the infection. Researchers hope these protein markers could one day help doctors choose the right treatment faster. About 750 patients already scheduled for a l…

This study follows up to 600 people with or at risk for Hyper IgE syndrome, a rare immune condition causing severe skin and lung infections. Researchers will track health over time, study genetics, and look for new causes. The goal is to better understand the disease, not to test…

This study looks at how medical oxygen is provided in six countries in Africa and Asia. Researchers will interview policymakers, health workers, and others to find out what works and what doesn't. The goal is to improve oxygen access for people with breathing problems like pneumo…

This study tests whether computer alerts in the electronic health record can help doctors avoid prescribing antibiotics when they aren't needed for children with lower respiratory tract infections like pneumonia, bronchiolitis, or asthma flare-ups. Most of these infections are ca…

This study is collecting blood and other samples from 2,000 adults who come to the emergency room with a suspected respiratory infection. The goal is to build a biobank to better understand how different infections affect the body. Researchers hope this will lead to new ways to d…

This study tests if sodium bicarbonate (a common medicine) can be used as a safe contrast agent to map lung blood flow using electrical impedance tomography (EIT) in adults on breathing machines. About 41 ICU patients will receive two small injections through an existing IV line,…

This study looks at whether a therapy called OLE (Oscillatory Lung Expansion) helps ICU patients with pneumonia clear mucus from their lungs. Researchers will use a special imaging technique (EIT) to see how the lungs respond. About 62 adults in the ICU will take part, and the ma…

This study uses a special type of MRI (called hyperpolarized xenon MRI) to look at lung function in adults who have had a bone marrow transplant and developed lung problems like bronchiolitis obliterans syndrome. Researchers want to see if this imaging can better measure how well…

This study looks at how certain medicines act in the bodies of children and young adults under 21. Researchers want to find the safest and most effective doses for these age groups. Participants are already receiving these drugs as part of their normal care. No new treatments are…

This study looks at the bacteria and their antibiotic resistance genes in 800 people with pneumonia. Researchers will compare severe and mild cases to understand which resistance genes are present. The goal is to improve how doctors diagnose and treat pneumonia by knowing which a…

This study is watching 800 people with severe pneumonia in the intensive care unit to learn more about the disease. Researchers will track symptoms, treatments, and outcomes to better understand what causes severe pneumonia and how to improve care. The goal is to gather informati…

This study looks at infections that happen after surgery to remove esophageal cancer. Researchers will review records of 350 adults who had this surgery in France between 2017 and 2024. The goal is to find out what causes these infections and how they affect recovery, so doctors …

This study is observing 4,000 adults in intensive care with ARDS, sepsis, or pneumonia to identify different types of these illnesses. Researchers will collect medical information and samples to build a biobank for future studies. The goal is to improve understanding of risk fact…

This study looks at whether scheduling automatic follow-up appointments after a child leaves the hospital is better than letting parents decide if one is needed. About 2,674 children hospitalized for infections like pneumonia or urinary tract infections will take part. The goal i…

This study looks at whether a special hospital unit called an Acute Medical Unit (AMU) can provide better care for older adults with sudden illnesses like infections, falls, or COPD flare-ups. Researchers will compare patients who go to the AMU with those who get usual hospital c…

This early-stage study tests a new tablet form of the experimental COVID-19 drug ibuzatrelvir in 18 healthy adults. Researchers want to see how much of the drug gets into the blood with the new tablet compared to the original, and whether taking it with food or as a drink changes…

This study looks at whether using lung ultrasound to diagnose pneumonia in children aged 3 to 10 can cut down on unnecessary antibiotic use. Currently, doctors often rely on exams and chest X-rays, which aren't always accurate. The goal is to see if ultrasound can guide better tr…