PNEUMONIA

This study looks at how well a 20-valent pneumococcal vaccine works against pneumonia in adults aged 65 and older. Participants are hospitalized with suspected pneumonia and provide a urine sample to check for specific bacterial strains. Researchers compare vaccination rates betw…

This study looks at whether low-intensity laser therapy can improve the immune response in children with Down syndrome who have pneumonia. Forty children will receive either laser therapy plus breathing exercises and standard medical care, or just breathing exercises and standard…

This study looks at whether children with complex medical conditions who are hospitalized for pneumonia can safely stop antibiotics sooner once they are clinically stable. Researchers will track how many families agree to the approach and monitor for any return of symptoms or hos…

This study tests whether adding a gentle brain stimulation technique (rTMS) to standard swallowing therapy can lower the chance of pneumonia in people who have trouble swallowing after a stroke. About 70 adults with moderate to severe swallowing difficulty will be enrolled. The g…

This large study tests various treatments for people hospitalized with pneumonia, including from COVID-19 and flu. The main goal is to see which treatments reduce the risk of death. Over 70,000 participants are involved, and the study compares multiple drugs to standard care.

This study looks at how to best treat children aged 6 months to 18 years who come to the emergency room with pneumonia but are well enough to go home. The goal is to see if doctors can safely use fewer antibiotics while still helping kids get better quickly. About 700 children wi…

This study looks at whether using higher positive pressure during noninvasive ventilation (a mask that helps you breathe) can help people with pneumonia or acute respiratory distress syndrome (ARDS) avoid needing a breathing tube. About 700 adults who are awake and need mask brea…

This study tests an experimental drug called AV-001 in 120 hospitalized adults with pneumonia who need extra oxygen. The drug is given daily through an IV and compared to a placebo, alongside standard care. The goal is to see if AV-001 is safe and helps patients recover faster fr…

This study tests whether a special blood filter (oXiris) works better than a standard filter (M100) for people with pneumonia who also develop acute kidney injury. About 60 adults will be enrolled to see which filter reduces inflammation and improves survival over 28 days. The go…

This study tests a new ventilator (INBENTUS VERSATILE) in 81 adults who need help breathing due to conditions like pneumonia, ARDS, or COPD. Participants will use the ventilator for 3 to 48 hours, and researchers will monitor for side effects and how well the machine works. The g…

This study checks if standard heart and blood flow monitors work correctly in patients on ECMO, a machine that adds oxygen to blood outside the body. Researchers will compare three monitoring methods in 30 adults on ECMO for severe lung failure. The goal is to improve how doctors…

This study looks at better ways to diagnose pneumonia in older adults (65+) who come to the emergency room. Researchers will test 250 patients and use new biomarkers to tell if pneumonia is bacterial, viral, or both. The goal is to create a clearer, more accurate diagnostic path …

This study is testing a device called Inflammacheck that measures certain chemicals in your breath to see if it can help doctors tell the difference between lung cancer, other lung diseases, and healthy lungs. About 140 adults will take part, including people with lung cancer, pn…

This study checks how accurate standard circulation monitors are for patients on ECMO, a machine that pumps and oxygenates blood outside the body. Researchers will compare three different monitoring methods in 30 adults aged 18–75 who are on ECMO. The goal is to improve how docto…

This study is testing a new ultrasound measurement called the Lung Sliding Index (LSI) to see if it can help doctors tell apart different lung diseases like COPD, pneumonia, and pneumothorax. Researchers will enroll 700 adults with various lung conditions and healthy volunteers t…

This study tests a new portable X-ray machine that takes moving images of the lungs at the bedside in the ICU. It aims to see if this technology can give doctors better information about lung function and blood flow compared to standard X-rays. About 230 adults with various lung …

This study tests whether improved oral hygiene combined with antibiotics can prevent pneumonia in people who have had a brain hemorrhage. About 440 adults with a small to medium-sized bleed will be randomly assigned to receive either standard care or enhanced mouth care plus anti…

This study tests whether high doses of inhaled nitric oxide (a gas) can help severely ill pneumonia patients who are on breathing machines. About 34 adults will receive either the gas or a placebo for 5 days. Researchers will track how the body handles the gas and whether it impr…

This study tests whether adding a special breathing treatment called intrapulmonary percussive ventilation (IPV) to standard care helps pneumonia patients on ventilators recover faster. About 96 adults will be randomly assigned to receive either standard care alone or standard ca…

This study compares a combination of two sedatives (propofol and ketamine) against propofol alone in elderly ICU patients who need a breathing tube. The goal is to see if the combo reduces dangerous drops in blood pressure. The trial involves 41 patients aged 65 or older with hea…

This study tests a personalized approach to giving steroids to adults hospitalized with pneumonia. Instead of a standard dose, doctors will use a blood test (CRP) to decide the right amount for each patient. The goal is to reduce steroid side effects while still controlling lung …

This study tests if exposure to bright blue light can reduce inflammation and organ damage in patients hospitalized with serious infections like pneumonia, infected joints, or abdominal infections. About 144 adults will be assigned to either blue light or standard hospital light …

This study looks at how medical oxygen is provided in six countries in Africa and Asia. Researchers will interview policymakers, healthcare workers, and others to understand challenges and find solutions. The goal is to improve oxygen access for patients with conditions like pneu…

This study looks at the bacteria and their antibiotic resistance genes in 800 people with pneumonia. Researchers will compare severe and mild cases to understand which resistance genes are present. The goal is to improve how doctors diagnose and treat pneumonia by knowing which a…

This study is watching 800 people with severe pneumonia in the intensive care unit to learn more about the disease. Researchers will track symptoms, treatments, and outcomes to better understand what causes severe pneumonia and how to improve care. The goal is to gather informati…

This study uses a special MRI scan (Xenon gas) to measure lung function in 25 adults who had a stem cell transplant and developed lung issues. Researchers want to see if this scan can detect early signs of lung damage and predict if the condition will get worse over time. The stu…

This study looks at whether a special breathing therapy called OLE (Oscillatory Lung Expansion) helps ICU patients with pneumonia clear mucus from their lungs. Researchers will use a lung imaging tool (EIT) to see how well the therapy works. About 62 adults in the ICU who have a …

This study tests whether computer-based alerts in the electronic health record can help doctors avoid prescribing antibiotics when they aren't needed for children with lower respiratory tract infections like pneumonia, bronchiolitis, or asthma flare-ups. Most of these infections …

This study looks at infections that happen after surgery to remove esophageal cancer. Researchers will review records of 350 adults who had this surgery in France between 2017 and 2024. The goal is to find out what causes these infections and how they affect recovery, so doctors …

This study is observing 4,000 adults in intensive care with ARDS, sepsis, or pneumonia to identify different types of these illnesses. Researchers will collect medical information and samples to build a biobank for future studies. The goal is to improve understanding of risk fact…

This study looks at whether scheduling automatic follow-up appointments after a child leaves the hospital is better than letting parents decide if one is needed. About 2,674 children hospitalized for infections like pneumonia or urinary tract infections will take part. The goal i…

This study looks at whether a special hospital unit called an Acute Medical Unit (AMU) can provide better care for older adults with sudden illnesses like infections, falls, or COPD flare-ups. Researchers will compare patients who go to the AMU with those who get usual hospital c…

This study looks at proteins in lung fluid from people with pneumonia to find clues about what causes the disease. Researchers hope to identify biomarkers that could help doctors choose the right treatment. Up to 750 patients already scheduled for a lung exam will provide a small…

This study aims to learn more about Hyper IgE syndrome, a rare immune disorder that causes severe skin and lung infections. Researchers will follow up to 600 patients and their relatives over time, using exams and genetic tests to understand the disease better. No new treatments …

This study is testing whether a common substance, sodium bicarbonate (baking soda), can be used as a safe contrast agent to create images of lung blood flow using a bedside device called electrical impedance tomography (EIT). The study involves 41 adults in the intensive care uni…

This study looks at how certain medicines act in the bodies of children and young adults under 21. Researchers want to find the safest and most effective doses for these age groups. Participants are already taking these drugs as part of their regular care, or have had a recent CO…

This early-stage study tests a new tablet form of the experimental COVID-19 drug ibuzatrelvir in 18 healthy adults. Researchers want to see how much of the drug gets into the blood with the new tablet compared to the original, and whether taking it with food or as a drink changes…

This study looks at whether using lung ultrasound to diagnose pneumonia in children aged 3 to 10 can cut down on unnecessary antibiotic use. Currently, doctors often rely on exams and chest X-rays, which aren't always accurate. The goal is to see if ultrasound can guide better tr…