PNEUMONIA

This early-phase trial will test a combination of a Chinese herbal formula (Yiqi Huoxue Jiedu) and bacteriophages (viruses that target bacteria) in 250 people with severe pneumonia caused by drug-resistant bacteria. The goal is to see if this combo can clear the infection faster …

This study looks at whether giving lower doses of two blood thinners (argatroban and enoxaparin) to adults on ECMO (a machine that helps the heart and lungs) is safe and works well. The goal is to reduce bleeding and clotting problems. About 200 people with pneumonia or heart fai…

This study tests whether a pharmacist-led electronic consultation can improve lung health for people with HIV who smoke or use certain medications that raise pneumonia risk. Pharmacists will review records and suggest changes like smoking cessation aids, vaccines, or stopping unn…

This study tests whether adding probiotic nasal spray and oral probiotics to standard pneumonia treatment helps children aged 6 to 36 months recover faster. 330 children will be split into three groups: one getting a placebo, one getting probiotic nasal spray only, and one gettin…

This early-phase trial tests a Chinese herbal formula (Yiqi Huoxue Jiedu) combined with bacteriophages—viruses that target specific bacteria—in 240 people with severe pneumonia caused by drug-resistant germs. The goal is to see if the combination clears the infection faster and l…

This study tests whether an AI-powered digital stethoscope can help health workers more accurately diagnose pneumonia in children aged 2 months to 5 years. 350 children with cough or breathing difficulty will be randomly assigned to standard care or care plus the AI stethoscope. …

This study tests an AI system that helps doctors navigate a bronchoscope (a thin tube with a camera) into the lungs of patients with severe pneumonia. The AI provides real-time visual cues and voice prompts to guide the doctor to the right spot and describe what they see. About 1…

This study will test whether a new urine-based test can accurately diagnose pneumococcal pneumonia in children under 5 in Malawi. Researchers will use 350 stored urine samples from healthy kids and those with pneumonia, comparing results to standard lab methods. If it works, this…

This study tests whether using a high-flow nasal cannula (a device that delivers warm, moist oxygen at high speeds) for 24 hours after major abdominal surgery can prevent lung complications like pneumonia or collapsed lungs. Researchers will compare this to standard oxygen therap…

This study tests whether a ketogenic diet (low carb, high fat) is better than a standard diet at preserving muscle function in older adults hospitalized with pneumonia. Researchers will enroll 30 patients aged 55 and older and measure handgrip strength and diet adherence. The goa…

This study tests a mobile mindfulness program called Lift for people who survived a serious illness in the ICU and now struggle with depression, anxiety, or stress. About 450 adults will use either the Lift app or a health education app for 6 months. The goal is to see if the min…

This study tests four different nebulized solutions (various salt concentrations and distilled water) to see which works best for clearing mucus from the airways of pneumonia patients. Eighty adults with pneumonia who need help coughing up phlegm will receive the treatment four t…

This study looks at whether a special oxygen device (high-flow nasal cannula) can prevent dangerously low oxygen levels in children aged 1 to 6 years who are sedated for a lung exam called bronchoscopy. About 430 children will be randomly assigned to receive either the high-flow …

This study looks at two ways to sedate children aged 5-10 who are on breathing machines for pneumonia. One method gives sedation continuously, the other pauses it daily. Researchers will measure comfort levels to see which approach works better. The goal is to improve care and re…

This study tests whether pursed-lip breathing exercises, done twice daily with a toy, can improve breathing and readiness for hospital discharge in 66 children aged 3-4 with pneumonia. Researchers will measure changes in heart rate, breathing rate, and oxygen levels before and af…

This study looks back at the medical records of 500 adults hospitalized with pneumonia to learn more about the disease. Researchers want to understand what factors affect patient outcomes, such as age, other health conditions, and lab results. The goal is to improve how pneumonia…

This study will follow about 2,700 adults with pneumonia to track their recovery and understand why some become severely ill. Researchers will collect health data and samples to find patterns that predict worsening. The goal is to improve how doctors assess risk and make treatmen…

This observational study will enroll 50 children in intensive care with suspected pneumonia. Researchers will use a new technology called metagenomics to detect all bugs in the lung, and also measure how the body's cells and proteins respond. The goal is to see if this combined a…

This study tests whether a chatbot called 'Pneumonia Care Helper' can improve the knowledge, attitudes, and caregiving skills of people caring for elderly pneumonia patients. 150 caregivers will either use the chatbot with educational videos for 5 days or receive standard paper i…

This study looks at whether patients who get a breathing tube in an emergency are more likely to develop pneumonia than those who get one in a planned setting. Researchers will review medical records of 600 adults intubated in 2024. The goal is to understand the risk and improve …

This study will follow 2,000 people—children under 5 and adults aged 16-60—in 30 villages in rural India to track how often they get serious lung infections from RSV, flu, COVID-19, and other viruses. Researchers will visit homes weekly and test samples to measure how many cases …

This study will use bedside ultrasound to look at the diaphragm and other breathing muscles in 150 ICU patients with pneumonia who are on a breathing machine. The goal is to see if muscle measurements can help predict whether a patient will successfully come off the machine or fa…

This study checks if a Turkish version of the Respiratory Distress Observation Scale (RDOS) accurately measures breathing distress in critically ill patients who cannot speak. Researchers will compare RDOS scores with end-tidal carbon dioxide levels, an objective breathing measur…

This study looks at how the immune system works in people with lung diseases like asthma, COPD, pneumonia, and tuberculosis. Researchers will take a single blood sample from 100 adults to study immune cell changes during inflammation and infection. Participants won't receive dire…

This study will observe up to 4,000 children under 5 years old who test positive for RSV and visit emergency departments in Turkey. Researchers will track how many children need to be admitted to the hospital or intensive care, and what treatments they receive. The goal is to bet…

This study looks at how different levels of positive end-expiratory pressure (PEEP) on a ventilator affect the diaphragm and lungs in ICU patients with respiratory failure. Twenty-five adults on pressure support ventilation will each receive low, medium, and high PEEP for short p…

This study looks for proteins in the blood that could signal transfusion-related acute lung injury (TRALI), a rare but dangerous complication in ICU patients. Researchers will compare blood samples from 210 people, including ICU patients with and without lung injury, and healthy …