Ventilator pressure showdown: which setting saves lungs best?

NCT ID NCT07188038

Not yet recruiting Knowledge-focused Sponsor: Vastra Gotaland Region Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study looks at how different levels of positive end-expiratory pressure (PEEP) on a ventilator affect the diaphragm and lungs in ICU patients with respiratory failure. Twenty-five adults on pressure support ventilation will each receive low, medium, and high PEEP for short periods. Researchers will measure diaphragm activity, breathing effort, and lung mechanics using special catheters and ultrasound.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could help doctors choose the best ventilator settings to protect the lungs and diaphragm in critically ill patients.
What could go wrong: This is a small, early-stage study with only 25 participants, so results may not apply to all patients. It measures short-term effects, not long-term outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute lung injury acute respiratory distress syndrome pneumonia respiratory failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ARDS (ACUTE RESPIRATORY DISTRESS SYNDROME) PNEUMONIA RESPIRATORY FAILURE RESPIRATORY INSUFFICIENCY

Contacts and locations

Locations

Central intensivvårdsavdelning, Sahlgrenska University Hospital

Gothenburg, Västra Götaland County, 413 45, Sweden
Thorax intensivvårdsavdelning, Område 6, Sahlgrenska University Hospital, Västra Götalandsregionen

Gothenburg, Västra Götaland County, 413 45, Sweden

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