RESPIRATORY FAILURE

This study tests if a high-flow nasal cannula (a device that delivers warm, moist oxygen through the nose) works better than non-invasive ventilation (a mask that helps push air into the lungs) to prevent breathing failure after a breathing tube is removed. It includes 50 adults …

This study compares two methods of helping patients breathe during a cardiac arrest in the hospital: a supraglottic airway (a tube placed above the voice box) versus endotracheal intubation (a tube placed into the windpipe). About 1,060 adults who suffer cardiac arrest in the hos…

This study looks at whether using a high-flow nasal cannula along with noninvasive ventilation helps people with acute respiratory failure breathe better than noninvasive ventilation alone. It will include 75 adults in the ICU. The main goal is to see if oxygen levels in the bloo…

This study compares three ways to help people with severe low oxygen levels breathe better without needing a breathing tube: a helmet that pushes air in, a helmet that keeps airways open (CPAP), and high-flow oxygen through the nose. About 1,200 adults with acute respiratory fail…

This study tests whether using a real-time lung imaging technique called electrical impedance tomography (EIT) to guide breathing exercises can help adults who have been on a ventilator for 21 days or more get off the machine faster. Two hundred participants will either receive s…

This study looks at two ways of using a heart-lung machine (ECMO) during lung transplants: using it for every patient or only when needed. The goal is to find out which method leads to fewer complications and better recovery. About 218 adults getting a lung transplant will take p…

This study compares two methods (pressure support ventilation and T-piece) used to test if overweight ICU patients are ready to have their breathing tube removed. About 100 adults with a BMI of 25 or higher who have been on a ventilator for over 24 hours will be randomly assigned…

This study tests a non-invasive light and magnetic field therapy (PBMT-sMF) in 112 adults on mechanical ventilators. The goal is to see if it reduces ICU stay and prevents diaphragm muscle weakening. Participants receive either active therapy or a placebo, alongside standard care…

This study looks at whether exercising in your community or at home can improve how well your heart and lungs work. Researchers will compare people who exercise regularly with those who don't. The goal is to find a safe and effective way for people with conditions like heart dise…

This study compares two sedatives, ciprofol and propofol, in ICU patients who need breathing support but are not on a ventilator. The goal is to see which drug works better and causes fewer breathing problems. About 1,680 adults from 30 hospitals in China will be included, and re…

This study looks at whether playing music for children in the pediatric ICU can lower stress and improve vital signs like heart rate and breathing while they are being taken off a ventilator. About 82 children will be randomly assigned to receive either standard care or standard …

This study looks at how lying on the stomach (prone position) changes lung function in patients with severe breathing problems (ARDS). Researchers will use a special 3D imaging technique called EIT to see air and blood flow in the lungs. The goal is to better understand why prone…

This study tests whether a supraglottic airway (a small mask placed over the voice box) can be used as the main tool to help premature babies breathe during resuscitation right after birth. The trial will include 20 infants born between 29 and 33 weeks who need breathing support.…

This study watches 100 adults who needed a machine called ECMO for severe heart or lung failure. Researchers want to see how muscle loss and weakness affect their recovery and quality of life. They will use ultrasound, strength tests, and questionnaires to track changes over time…

This study looks at how different types of blood platelets change in adults who need ECMO support for severe heart or lung failure. Researchers will take blood samples on days 1, 3, and 7 after ECMO starts to track these changes. The goal is to better understand why some patients…

This study looks at how changing the pressure in a breathing machine (ventilator) affects the effort patients need to breathe on their own. It will include 12 adults in the ICU who are already using a ventilator to help them breathe. Researchers will test four different pressure …

This study looks back at medical records of about 60 ICU patients who used a low-flow ECCO2R machine to help remove carbon dioxide from their blood when their lungs were failing. The goal is to describe how the therapy was used and what outcomes patients had, including side effec…

This study looks at how the oxygen level target and the type of oximeter used together affect the amount of oxygen patients need. It includes 40 adults in the cardiac surgery ICU who are either breathing on their own or on a ventilator. The goal is to see if using a higher oxygen…

This study tests whether training ICU staff to keep oxygen levels in a specific range (90-96%) helps patients on breathing machines. Researchers will track how many days patients are free from the ventilator and how often dangerously low oxygen goes unnoticed. The goal is to impr…

This study is developing a new scoring tool called REXs to help doctors decide when it is safe to remove a breathing tube from patients in the intensive care unit (ICU). The tool combines several medical measurements to predict whether a patient can breathe on their own without n…

This study looks at a new way to set breathing machine pressure for people with obesity who need a ventilator. It involves 30 patients with a BMI of 30 or higher. The goal is to see if this method is practical and safe enough to test in a larger study.

This study looks at 30 preterm and term infants in the NICU who need a breathing tube. Researchers will compare a new FDA-approved suction device (EXSALTA) with the standard wall suction to see which causes less stress on the baby's heart rate and oxygen levels. The goal is to fi…

This study aims to improve how emergency call operators identify life-threatening conditions like heart attack, stroke, and breathing problems over the phone. Researchers will analyze millions of past emergency calls using artificial intelligence to find patterns that help spot s…

This study collects blood and tissue samples from 100 adults who have had a lung transplant in the last 10 years. Researchers will use these samples to study biomarkers and how infections affect outcomes. The goal is to improve care for people with advanced lung disease, not to t…

This study looks at how the diaphragm—the main breathing muscle—weakens in patients on a breathing machine (mechanical ventilation) in the ICU. Researchers will use mild nerve stimulation and ultrasound to measure muscle strength and brain control over time. The goal is to unders…

This study looks at whether using an EEG (a device that measures brain activity) can help doctors and nurses better understand sleep quality in ICU patients with acute respiratory failure. About 47 adults will have their sleep tracked by both EEG and nurse checks. The goal is to …

This study looks at whether a special ultrasound technique can help doctors set the right oxygen flow for patients with breathing failure. Researchers will measure how the diaphragm moves and works in 100 adults, including healthy volunteers and ICU patients. The goal is to see i…