RESPIRATORY FAILURE

This study aims to find which of two short breathing tests better prepares overweight and obese ICU patients to have their breathing tubes safely removed. Researchers will randomly assign 100 eligible adults to try either a pressure support ventilation or a T-piece method for one…

This study aims to determine the best way to use a heart-lung machine (called ECMO) during lung transplant surgery. Researchers will compare using the machine for every patient versus only using it when problems arise during surgery. The goal is to see which approach helps patien…

This study is testing if teaching hospital staff to aim for a specific, slightly lower oxygen level (90-96%) in adult ICU patients on breathing machines helps them recover faster. The main goal is to see if this approach reduces the number of days patients need the ventilator. It…

This study is testing whether an 8-week exercise program done at home or in the community can improve fitness and quality of life for adults with reduced heart or lung function. Researchers will compare 200 participants who do the exercise program to those who do not. The program…

This study tests which breathing support method works best to avoid putting patients on mechanical ventilators. It compares two types of helmet-based breathing support against high-flow nasal oxygen in 1,200 ICU patients with severe breathing failure. The main goal is to see whic…

This study compares two breathing support methods for heart failure patients coming off ventilators. Researchers want to see which approach better prevents patients from needing the ventilator again within 72 hours. The trial includes 50 adults with weakened heart function who ha…

This study is testing a new scoring tool called the Readiness for Extubation Score (REXs). It aims to help doctors in intensive care units better predict when patients on breathing machines are ready to have their breathing tubes safely removed. The study will involve 470 patient…

This study is testing whether listening to music can help children stay calm and stable when doctors remove their breathing tube in the intensive care unit. Researchers will compare children who receive standard care plus music therapy to those who receive standard care alone, me…

This study is testing whether adding two dietary supplements, L-arginine and vitamin C, to a standard 28-day lung rehabilitation program can help reduce severe fatigue in people with COPD and chronic breathing failure. About 102 participants will be randomly assigned to receive e…

This study is testing whether a new type of ultrasound measurement, called the Diaphragmatic Physiology Similarity Index (DPSI), can help doctors choose the best oxygen flow setting for a breathing machine. Researchers will observe 100 adults in the intensive care unit (ICU) with…

This study aims to understand how different brands of finger-clip oxygen monitors and different target oxygen levels affect how much oxygen doctors give to patients. Researchers will test two common monitor brands (Nonin and Philips) and two oxygen level targets (90% and 94%) in …

This study aims to understand how and why the diaphragm muscle weakens in ICU patients who need breathing machine support. Researchers will measure the strength and nerve control of the breathing muscle during and after ventilator use in 15 patients. The goal is to gather detaile…

This study aims to understand why patients on ECMO life support machines often have serious bleeding or clotting problems. Researchers will closely track changes in different types of blood platelets in 75 adults with heart or lung failure during their first week on ECMO. The goa…

This study aims to better understand how turning patients with severe lung failure (ARDS) onto their stomach affects air and blood flow in different parts of the lungs. Researchers will use a special 3D imaging technique on 30 adult patients who are on breathing machines and need…

This study aims to understand why some patients develop severe muscle weakness after surviving a life-threatening heart or lung failure that required advanced life support (ECMO) in the intensive care unit. Researchers will observe 100 adult patients to see how their muscle size,…

This study is testing whether a specific breathing device, called a supraglottic airway, is practical to use as the first choice for helping premature babies breathe right after birth. It involves about 20 premature infants born between 29 and 34 weeks who need breathing support.…

This study aims to find out which of two common methods for helping patients breathe during a hospital cardiac arrest leads to better survival and recovery. It will compare using a simpler breathing device placed in the throat first versus using the more complex traditional breat…

This study looks at past medical records to understand how well and how safely a special therapy works for ICU patients with severe breathing failure. The therapy, called low-flow ECCO2R, helps remove carbon dioxide from a patient's blood. Researchers will review data from about …

This study aims to understand how adjusting a specific pressure setting on a breathing machine (ventilator) affects how hard a patient's own breathing muscles have to work. Researchers will test four different pressure levels in 12 adult patients who are stable but need ventilato…

This study collects blood and tissue samples from people with advanced lung diseases or who have had lung transplants. Researchers will store these samples in a biobank to study them later, looking for biological markers that could help diagnose conditions earlier or predict how …