RESPIRATORY FAILURE

This trial tests a real-time algorithm-driven system that gives doctors feedback on ventilator settings to protect the lungs of critically ill patients. The study will include 208 adults on breathing machines with acute respiratory distress syndrome (ARDS). The goal is to see if …

This study tests whether a personalized breathing machine strategy can improve survival in people with acute respiratory distress syndrome (ARDS), a severe lung condition. About 1,100 adults on ventilators will be randomly assigned to either standard care or a precision approach …

This trial tests whether a special alert system called ICU Beacon can help doctors in intensive care units detect early signs of organ failure. The study includes about 1,962 adult ICU patients and compares units using the software plus standard care to those using standard care …

This study compares two breathing support methods—high-flow nasal cannula (HFNC) and non-invasive ventilation (NIV)—in heart failure patients after their breathing tube is removed. The goal is to see which method better prevents the need for re-insertion of the breathing tube or …

This study tests whether using a real-time lung imaging tool (EIT) to guide breathing therapy helps people who have been on a breathing machine for a long time. The goal is to see if this personalized approach helps them breathe on their own sooner compared to standard therapy. T…

This study tests a device that uses light and a static magnetic field (PBMT-sMF) on adult ICU patients who need a breathing machine. The goal is to see if this therapy can reduce the number of days in the ICU and prevent diaphragm muscle weakness. Researchers will compare the act…

This study tests a method to set breathing machine pressures based on real-time lung measurements in obese patients. Researchers will insert a small balloon tube into the esophagus to measure lung pressure and adjust the ventilator accordingly. The goal is to see if this personal…

This study compares two ways of using a heart-lung support machine (ECMO) during lung transplants: using it routinely for all patients versus using it only when problems arise. About 218 adults with end-stage lung disease will take part. The goal is to see which approach leads to…

This trial compares two ways to help patients breathe during a cardiac arrest in the hospital: a supraglottic airway (a tube placed in the throat) versus endotracheal intubation (a tube placed into the windpipe). About 1,060 adults who suffer cardiac arrest while hospitalized wil…

This study tests three ways to help patients with severe low oxygen levels breathe better without needing a breathing tube. About 1,200 adults will be randomly assigned to receive either a helmet mask that pushes air, a helmet mask that keeps airways open, or high-flow oxygen thr…

This study is testing whether a community-based exercise program can improve exercise capacity in 200 adults aged 18-85 with reduced heart or lung function. Participants will exercise 40-60 minutes, five times a week, for eight weeks, doing activities like brisk walking, jogging,…

This pilot study tests a self-management program based on cognitive behavioral therapy to help people who survived acute respiratory failure and now struggle with anxiety. Sixty ICU survivors will either receive the program or usual care. The goal is to see if the program is prac…

This study looks at two sedatives, ciprofol and propofol, given to ICU patients who need breathing support but are not on a ventilator. The goal is to see which drug works better and causes fewer breathing problems. About 1,680 adults from 30 hospitals in China will be included, …

This study compares a new FDA-approved suction device (EXSALTA) to standard suctioning in 30 preterm and term infants who are on breathing tubes. The goal is to see if the new device causes smaller changes in heart rate, oxygen levels, and brain oxygen levels during suctioning. E…

This study compares two ways of giving breathing support to adults with acute respiratory failure in the ICU. One group gets standard noninvasive ventilation (a mask that helps breathing), while two other groups get that plus a high-flow nasal cannula (a device that delivers warm…

This study compares two methods of breathing trials for overweight and obese ICU patients before removing their breathing tube. One hundred adults with a BMI of 25 or higher who have been on a ventilator for over 24 hours will be randomly assigned to either pressure support venti…

This study tests whether music therapy can reduce stress and improve vital signs in children when their breathing tube is removed in the pediatric intensive care unit. About 82 children will be randomly assigned to receive either standard care alone or standard care plus music th…

This study looks at whether the natural variation in heartbeat timing (heart rate variability) can help doctors decide the right oxygen flow for patients with respiratory failure who are on a high-flow nasal cannula. Researchers will gradually lower the oxygen flow and monitor he…

This study tracks quality of life in 200 adults with chronic respiratory failure who use breathing support like non-invasive ventilation. Researchers will use questionnaires to see how treatments impact daily living over time. The goal is to better understand patient experiences,…

This study looks at how artificial intelligence (AI) can help emergency call operators quickly identify life-threatening situations like cardiac arrest, stroke, or severe breathing problems. Researchers will analyze millions of past emergency calls to train AI models to recognize…

This study looks at whether using an EEG (a device that measures brain activity) can give a more accurate picture of sleep quality in intensive care patients with acute respiratory failure, compared to the usual nurse assessments. About 47 adults in the ICU will have their sleep …

This study tests whether training ICU staff to keep oxygen levels between 90-96% helps patients on breathing machines recover faster. Researchers will track how many days patients are free from the ventilator and how often dangerously low oxygen goes unnoticed. The goal is to imp…

This study looks at how painkillers and sedatives are given to patients on ECMO, a life-support machine for severe heart or lung failure. Researchers will first review current sedation practices in UK hospitals, then work with patients, families, and staff to design a safer sedat…

This study aims to create a new scoring system called REXs to better predict when patients on breathing machines in the ICU are ready to breathe on their own. The researchers will test this score in 470 patients to see if it can reduce the number of patients who need to be put ba…

This study is testing whether a special breathing tube called a supraglottic airway can be used to help premature babies breathe right after birth. The study will include 20 premature infants born between 29 and 33 weeks who need breathing support. The goal is to see if this devi…

This study looks at whether a special ultrasound technique can help doctors choose the right oxygen flow for patients who have trouble breathing. Researchers will measure how the diaphragm moves in healthy people and in patients with respiratory failure. The goal is to see if thi…

This study looks at how changing the pressure inside the lungs (called PEEP) affects how hard patients have to work to breathe while on a ventilator. Twelve adults in the ICU who are already breathing with some help from a machine will have their PEEP set to four different levels…

This study uses a safe, radiation-free device called electrical impedance tomography (EIT) to take pictures of the lungs in infants, children, and young adults up to age 25. Researchers will compare images from patients with chronic lung or heart conditions to healthy controls to…

This study tracks how quickly the diaphragm weakens in 15 ICU patients on mechanical ventilation. Researchers use advanced muscle tests and brain stimulation to measure changes in diaphragm function and control. The goal is to better understand ventilator-induced diaphragm dysfun…

This study is building a bio-bank of blood samples from people who have had a lung transplant. Researchers will use these samples to study advanced lung diseases and improve transplant care. The goal is to better understand how infections and other factors affect patient outcomes…

This study will use a 3D electrical impedance tomography (EIT) device to monitor how lung ventilation and blood flow change when ARDS patients are placed on their stomach (prone position). Researchers will track 30 patients on mechanical ventilation at three time points: lying on…

This study looks at how different types of platelets change in patients on ECMO, a machine that helps the heart and lungs. Researchers will track 75 adults in intensive care to see if shifts in platelet populations relate to bleeding or clotting problems. The goal is to better un…

This study follows 100 adults who needed ECMO support for severe heart or lung failure. Researchers will track muscle size, strength, and quality of life over time to understand why some patients develop lasting weakness. No new treatments are being tested; the goal is to gather …

This study looks back at medical records of about 59 ICU patients who used a low-flow carbon dioxide removal (ECCO2R) machine for breathing failure. The goal is to describe how the device was used and what happened to patients, including survival and side effects. It does not tes…

This study involves 60 critically ill patients in the ICU who are on breathing machines (ventilators). Researchers want to see if a new scoring system can automatically detect when a patient is struggling to breathe. The goal is to improve how doctors monitor and care for these p…

This study looks at how different oxygen level targets and two types of oximeters affect the amount of oxygen given to patients in the intensive care unit. Researchers will test four combinations of target (90% or 94% oxygen saturation) and oximeter (Philips or Nonin) in 40 adult…