RESPIRATORY FAILURE

This study tested two ways of managing breathing during heart bypass surgery to see which better prevents lung complications. Over 1,500 adults having planned heart surgery were randomly assigned to either no breathing support or gentle, low-volume breaths while on the heart-lung…

This study tested whether it is possible to set personalized blood pressure targets for critically ill patients using a brain oxygen monitor. Sixteen ICU patients on breathing machines or shock medications had their blood pressure adjusted to match individual brain blood flow nee…

This study looked at whether giving nebulised heparin (a blood thinner delivered as a mist) to COVID-19 patients on mechanical ventilation could help them get off the breathing machine sooner and reduce deaths. The trial combined data from several smaller studies in Australia, Ir…

This study tested whether giving breathing support early (non-invasive ventilation and high-flow nasal oxygen) to people with chest injuries and low oxygen levels could prevent them from needing a breathing tube. 144 patients in the ICU took part. The goal was to see if this earl…

This study looked at 100 adults with COPD who needed a breathing tube and a ventilator. It compared two approaches: giving sedation with daily breaks versus giving no sedation at all. The goal was to see which method leads to more days off the ventilator and fewer complications i…

This study tested whether a newer breathing machine method (NAVA) helps patients with respiratory failure come off the ventilator faster than the usual method (PSV). The study included 47 adults who had trouble weaning from the ventilator. Researchers measured how long it took to…

This study tested whether a high-flow oxygen system (Optiflow) works better than a standard oxygen mask for patients with breathing failure. About 100 adults in intensive care who needed non-invasive ventilation (NIV) took part. The goal was to see if Optiflow keeps oxygen levels…

This study tested whether taking L-arginine and liposomal vitamin C supplements twice daily could reduce fatigue in people with COPD and chronic respiratory failure. 101 patients were randomly assigned to receive the supplements or a placebo during a 28-day pulmonary rehabilitati…

This study tested whether a computer-driven system called Smartcare/PS could help children with respiratory failure come off a breathing machine faster than usual care. Thirty children were enrolled, and the system automatically adjusted breathing support based on each child's ne…

This study tested whether adding a second nerve block (rectus sheath block) to a standard chest wall block (pectointercostal fascial plane block) improves pain control after heart surgery. 62 adults having elective heart surgery through a breastbone incision were randomly assigne…

This study tested whether critically ill patients on breathing machines could safely manage their own sedation using a button-controlled device. 161 adults in the ICU were randomly assigned to either self-manage their sedation or have it managed by a nurse. The goal was to see if…

This study observed over 1,600 adults in French emergency rooms to understand how patients are managed in the resuscitation area and whether being admitted directly to that area versus later affects their need for intensive care within 24 hours. Researchers recorded patient detai…

This study tests an artificial intelligence program designed to predict the best time to remove a breathing tube (extubation) from patients in intensive care. Researchers will use data from 1500 adults who were on a ventilator for at least 72 hours across four hospitals. The AI a…

This study looked at whether using a checklist before placing a breathing tube in intensive care unit (ICU) patients reduces complications. Researchers reviewed records of 60 critically ill adults who needed a breathing tube, comparing those treated before and after the checklist…

This study looked at whether lying face down (prone position) while awake can improve how air moves through the lungs in COVID-19 patients with breathing failure. Twenty adults with COVID-19 and low oxygen levels were monitored using a special imaging technique (EIT) to measure l…

This study looked at how well CPAP therapy works for COVID-19 patients who have trouble breathing. Researchers collected data from 250 patients in a hospital to see how they responded to treatment. The goal was to learn more about managing severe COVID-19 in real-life settings.

This study looked at 28 ICU patients on breathing machines to see if a diaphragm ultrasound could catch a specific breathing problem called double triggering. Researchers compared the ultrasound results to standard ventilator readings. The goal is to find a better way to monitor …

This pilot study tested three common ventilator modes—volume control, pressure control, and adaptive pressure control—in 566 ICU adults with respiratory failure. The goal was to see which mode leads to more days alive and off the ventilator. The study is a first step to guide fut…

This University of Oxford study looked at 48 ICU patients on ventilators for respiratory failure. Doctors sometimes inflate the lungs briefly (a recruitment manoeuvre) to reopen collapsed areas, but it's unclear when this helps. Researchers used a device to measure lung volume an…

This study looked at 77 ICU patients on breathing machines who needed a tracheostomy. Doctors used either a camera (bronchoscopy) or ultrasound to guide the procedure. The goal was to see which method caused fewer changes in breathing and blood gas levels. The results could help …

This study looked at 600 COVID-19 patients with severe breathing problems who were treated with high-flow nasal oxygen and asked to lie face-down (awake prone position). The goal was to see if this combination reduced the need for a breathing tube and lowered death rates. Researc…

This study looked at whether measuring tiny brain signals during a breathing test can help predict if a patient on a ventilator will successfully breathe on their own. Researchers monitored 70 intubated adults as they tried breathing without the machine. The goal is to find a sim…

This study looked at 212 critically ill adults in one ICU to see if three blood test ratios could predict death. The ratios compare lactate, CRP, and procalcitonin to albumin levels. Researchers will check if these ratios are linked to survival and find cut-off values to help doc…

This study looked at 24 critically ill patients on breathing machines to see how changing the machine's settings affects measurements of breathing effort. Researchers compared a simple bedside measurement with a more invasive gold-standard technique. The goal was to find the best…