RESPIRATORY FAILURE
Clinical trials for RESPIRATORY FAILURE explained in plain language.
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ICU breathing machine study tests which setting gets patients off ventilators faster
Disease control CompletedThis pilot study tested three different settings on breathing machines used in intensive care units (ICUs) for patients with severe respiratory failure. The goal was to see if one setting helps patients breathe on their own sooner than the others. The study involved 566 criticall…
Matched conditions: RESPIRATORY FAILURE
Phase: NA • Sponsor: Vanderbilt University Medical Center • Aim: Disease control
Last updated Mar 30, 2026 14:35 UTC
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Simple position change could help COVID patients avoid ventilators
Disease control CompletedThis study looked at a non-invasive treatment for adults with severe COVID-19 who were struggling to breathe. It combined high-flow oxygen through the nose with having patients lie on their stomachs while awake. The goal was to see if this approach could help patients avoid needi…
Matched conditions: RESPIRATORY FAILURE
Sponsor: Hospital Privado de Comunidad de Mar del Plata • Aim: Disease control
Last updated Mar 30, 2026 14:30 UTC
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Breath of hope: inhaled blood thinner tested to save ventilated COVID patients
Disease control CompletedThis international study tested whether inhaling a mist containing heparin, a common blood thinner, could help COVID-19 patients who need breathing machines. Researchers wanted to see if this treatment could help patients get off ventilators faster and improve survival. The trial…
Matched conditions: RESPIRATORY FAILURE
Phase: PHASE2, PHASE3 • Sponsor: Australian National University • Aim: Disease control
Last updated Mar 27, 2026 12:39 UTC
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Computer vs. doctor: race to get kids off life support
Disease control CompletedThis study tested whether a computer system could help children breathe on their own faster after being on a ventilator, compared to the usual care from doctors and therapists. It involved 30 children with respiratory failure. The goal was to see if the automated system could saf…
Matched conditions: RESPIRATORY FAILURE
Phase: NA • Sponsor: St. Justine's Hospital • Aim: Disease control
Last updated Mar 25, 2026 14:08 UTC
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Brain scan could help get patients off breathing machines sooner
Diagnosis CompletedThis study tested whether measuring brain activity could help doctors predict when patients in intensive care are ready to breathe on their own after being on a ventilator. Researchers used a simple, non-invasive EEG to measure brain signals during a standard breathing test in 70…
Matched conditions: RESPIRATORY FAILURE
Phase: NA • Sponsor: Poitiers University Hospital • Aim: Diagnosis
Last updated Mar 23, 2026 15:29 UTC
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ICU patients take control of their sedation to fight anxiety
Symptom relief CompletedThis study tested if letting critically ill patients on breathing machines control their own sedation medicine (using a button) works better than having nurses manage it. Researchers wanted to see if this self-management approach could reduce patient anxiety, shorten the time nee…
Matched conditions: RESPIRATORY FAILURE
Phase: PHASE2, PHASE3 • Sponsor: Mayo Clinic • Aim: Symptom relief
Last updated Apr 01, 2026 14:43 UTC
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New nerve block combo could ease heart surgery recovery
Symptom relief CompletedThis study tested whether adding a second type of nerve block to a standard pain control method improves recovery after heart surgery. Researchers compared pain levels, opioid medication use, and breathing function in 62 patients who received either one or two types of nerve bloc…
Matched conditions: RESPIRATORY FAILURE
Phase: PHASE1 • Sponsor: Medical College of Wisconsin • Aim: Symptom relief
Last updated Mar 27, 2026 12:39 UTC
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Three blood ratios could warn doctors which ICU patients are most at risk of dying
Knowledge-focused CompletedThis study looked back at medical records to see if three simple ratios calculated from common blood tests could predict which critically ill patients are most likely to die in the hospital. Researchers analyzed data from 212 adults admitted to a Polish intensive care unit in 202…
Matched conditions: RESPIRATORY FAILURE
Sponsor: Medical University of Silesia • Aim: Knowledge-focused
Last updated Apr 02, 2026 00:42 UTC
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Oxford scientists probe secrets of Life-Saving lung maneuver
Knowledge-focused CompletedThis study aimed to better understand a common ICU procedure used to re-inflate collapsed lungs in patients on breathing machines. Researchers observed 48 critically ill adults to learn which measurements can predict if this 'recruitment maneuver' will successfully open the lung.…
Matched conditions: RESPIRATORY FAILURE
Sponsor: University of Oxford • Aim: Knowledge-focused
Last updated Mar 30, 2026 14:28 UTC
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Doctors test simpler gauge for ventilator Patients' breathing strain
Knowledge-focused CompletedThis study tested a simple, bedside method for estimating how hard a patient on a breathing machine is working to breathe. Researchers compared this simple method to a more complex, gold-standard measurement in 24 critically ill adults with respiratory failure. The goal was to se…
Matched conditions: RESPIRATORY FAILURE
Phase: NA • Sponsor: Fondazione IRCCS San Gerardo dei Tintori • Aim: Knowledge-focused
Last updated Mar 27, 2026 12:39 UTC
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Doctors test if custom blood pressure can protect the brain in ICU
Knowledge-focused CompletedThis small pilot study tested whether doctors could find and use a personalized 'ideal' blood pressure target for patients in the intensive care unit (ICU). Researchers monitored patients' brain blood flow for 24 hours to find this target, then tried to keep their blood pressure …
Matched conditions: RESPIRATORY FAILURE
Phase: PHASE1, PHASE2 • Sponsor: Queen's University • Aim: Knowledge-focused
Last updated Mar 19, 2026 14:56 UTC
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Doctors study which tracheostomy method is safer for breathing
Knowledge-focused CompletedThis study looked back at medical records to compare two different guidance methods used during a common ICU procedure to insert a breathing tube (tracheostomy). It involved 77 adult patients who were on ventilators. The goal was to see if using an ultrasound or a small camera (b…
Matched conditions: RESPIRATORY FAILURE
Sponsor: Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization • Aim: Knowledge-focused
Last updated Mar 16, 2026 15:26 UTC