RESPIRATORY FAILURE

This study compares two ways of giving the blood thinner heparin to adults on a heart-lung machine (ECMO) for severe breathing problems. One group gets the standard IV drip, the other gets a shot under the skin. Researchers will check for bleeding, dangerous clots, and survival. …

This study tests whether an inhaled asthma medicine (salbutamol) can safely reduce breathing problems in newborns with transient tachypnoea, a condition where fluid stays in the lungs after birth. About 608 babies born between 32 and 42 weeks are taking part. The goal is to see i…

This study tests a simple checklist called CMOT to help ICU teams reduce distress when removing breathing machines from dying patients. About 184 patients and their care teams will take part across four ICUs. The goal is to see if this structured approach can make the process mor…

This study looks at whether changing from lying flat to sitting up improves oxygen levels in patients with respiratory failure who are on a breathing machine. Researchers will measure oxygen and carbon dioxide in the blood to see if position makes a difference. The study involves…

This study follows 500 adults who were in the ICU with breathing failure—some had COVID-19, some did not. Researchers want to see if COVID-19 leads to different long-term mental and physical problems. The goal is to better understand and treat these lasting effects.

This study was designed to measure lung pressure in people with severe obesity (BMI over 40) compared to those with normal weight. Researchers planned to use a small balloon in the esophagus and chest CT scans to understand how obesity affects breathing. The study was withdrawn b…

This study looks at whether the type of breathing machine setting used in the ICU affects how well patients recover. Over 4,700 critically ill adults on ventilators will take part across multiple hospitals. Researchers will switch the entire ICU's ventilator mode every two months…

This quality improvement study tests a digital tool (Respiratory Knowledge Portal) that gives ICU teams real-time feedback on ventilator settings and patient data. The goal is to help staff follow best practices, reduce ventilator-associated events, and improve outcomes for the 8…