Which ventilator mode saves more lives? massive ICU study aims to find out

NCT ID NCT07313956

ENROLLING_BY_INVITATION Knowledge-focused Sponsor: Vanderbilt University Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether the type of breathing machine setting used in the intensive care unit (ICU) affects how well patients recover. Researchers will switch the ventilator mode used across entire ICUs every two months and track outcomes like days alive without a breathing machine and survival. About 4,785 adults on ventilators will take part to help doctors choose the best approach for future patients.

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Conditions

The condition(s) this trial relates to.

Critical Illness respiratory failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CRITICAL ILLNESS MECHANICAL VENTILATION RESPIRATORY FAILURE

Contacts and locations

Locations

Rush University Medical Center

Chicago, Illinois, 60612, United States
The Johns Hopkins Hospital

Baltimore, Maryland, 21224, United States
Vanderbilt University Medical Center

Nashville, Tennessee, 37232, United States
Wake Forest University Health Sciences

Winston-Salem, North Carolina, 27109, United States

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