Can custom ventilation save more ARDS lungs?

NCT ID NCT06066502

Recruiting now Disease control Sponsor: Beth Israel Deaconess Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 30, 2026 · Updated 2 times

Summary

This study tests whether a personalized breathing machine strategy can improve survival in people with acute respiratory distress syndrome (ARDS), a severe lung condition. About 1,100 adults on ventilators will be randomly assigned to either standard care or a precision approach that adjusts settings based on each patient's lung mechanics. The main goal is to see if the personalized strategy reduces deaths within 60 days.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: precision ventilation strategy
What this could lead to: If successful, this personalized ventilation approach could reduce deaths from acute respiratory distress syndrome (ARDS) by tailoring breathing support to each patient's lung mechanics.
What could go wrong: This is a large phase 3 trial, but the intervention is complex and may not improve survival over standard care. Results may not apply to all ARDS patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute respiratory distress syndrome adult acute respiratory distress syndrome Critical Illness respiratory failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE RESPIRATORY DISTRESS SYNDROME RESPIRATORY FAILURE

Contacts and locations

Locations

Albert Einstein College of Medicine/Montefiore Medical Center
RECRUITING

The Bronx, New York, 10461, United States
Atrium Health Wake Forest Baptist
RECRUITING

Winston-Salem, North Carolina, 27157, United States
Baylor College of Medicine / St. Luke's Medical Center
RECRUITING

Houston, Texas, 77030, United States
Beth Israel Deaconess Medical Center
RECRUITING

Boston, Massachusetts, 02215, United States
Brigham and Women's Hospital
RECRUITING

Boston, Massachusetts, 02115, United States
Cedar-Sinai Medical Center
RECRUITING

Los Angeles, California, 90048, United States
Cleveland Clinic Foundation
RECRUITING

Cleveland, Ohio, 44195, United States
Duke University Medical Center
RECRUITING

Durham, North Carolina, 27710, United States
Emory University / Grady Health System
NOT_YET_RECRUITING

Atlanta, Georgia, 30322, United States
Intermountain Health
RECRUITING

Murray, Utah, 84107, United States
Lowell General Hospital
NOT_YET_RECRUITING

Lowell, Massachusetts, 01854, United States
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
Mayo Clinic
RECRUITING

Rochester, Minnesota, 55905, United States
NYU Lagone Health
RECRUITING

New York, New York, 02114, United States
New York City Health + Hospitals/ Bellevue
RECRUITING

New York, New York, 10016, United States
Ohio State University Wexner Medical Center
RECRUITING

Columbus, Ohio, 43210, United States
Oregon Health & Science University
RECRUITING

Portland, Oregon, 97239, United States
Stanford University
RECRUITING

Palo Alto, California, 94305, United States
Thomas Jefferson University
RECRUITING

Philadelphia, Pennsylvania, 19107, United States
Tufts Medical Center
RECRUITING

Boston, Massachusetts, 02111, United States
University of Arizona
RECRUITING

Tucson, Arizona, 85724, United States
University of Arkansas for Medical Sciences
RECRUITING

Little Rock, Arkansas, 72205, United States
University of California, Los Angeles Medical Center
RECRUITING

Los Angeles, California, 90024, United States
University of California, San Diego
RECRUITING

La Jolla, California, 92093, United States
University of California, San Francisco
RECRUITING

San Franciso, California, 94143, United States
University of Chicago
RECRUITING

Chicago, Illinois, 60637, United States
University of Cincinnati
RECRUITING

Cincinnati, Ohio, 45267, United States
University of Miami
RECRUITING

Miami, Florida, 33136, United States
University of Michigan
RECRUITING

Ann Arbor, Michigan, 48109, United States
University of Oklahoma Health Sciences
NOT_YET_RECRUITING

Oklahoma City, Oklahoma, 73104, United States
University of Utah
RECRUITING

Salt Lake City, Utah, 84132, United States
University of Virginia
RECRUITING

Charlottesville, Virginia, 22908, United States
University of Washingont/Harborview Medical Center
RECRUITING

Seattle, Washington, 98104, United States

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