Beth Israel Deaconess Medical Center

This study compares high flow oxygen to standard oxygen for adults with dangerously low blood oxygen (acute hypoxemia) in five East African hospitals. Researchers want to see if high flow oxygen lowers death rates and uses oxygen more efficiently. About 1,600 participants will be…

This study tests whether a personalized breathing machine strategy can improve survival in people with acute respiratory distress syndrome (ARDS), a severe lung condition. About 1,100 adults on ventilators will be randomly assigned to either standard care or a precision approach …

This Phase 3 trial is testing whether people who have a brain hemorrhage (bleeding stroke) should continue or stop taking their statin medication. The study will follow 1,456 participants for years to see which strategy leads to fewer repeat bleeds or other serious events. It als…

This phase 2 trial is testing a combination of radiation beads (Y-90), immunotherapy (durvalumab), and chemotherapy (gemcitabine and cisplatin) in 30 people with advanced bile duct cancer that cannot be removed surgically. The goal is to see if this mix can slow cancer growth and…

This study tests whether completing the gaps between lung lobes with surgery before placing standard lung valves can improve outcomes for people with severe emphysema or COPD. About 20 participants will either receive the combined procedure or standard medical care. The goal is t…

This pilot study tests a surgical procedure for people with severe emphysema or COPD who did not get enough benefit from a standard treatment using bronchoscopic lung volume reduction (valves). The surgery uses small chest incisions to complete the fissures between lung lobes and…

This study tests a special stent graft that doctors modify by hand to treat complex aortic aneurysms and dissections in patients who are too high-risk for standard surgery or devices. About 220 participants will be followed for up to 5 years to see if the procedure is safe and ef…

This study tests a flexible microwave ablation probe that can be guided through a bronchoscope to destroy small lung cancer nodules (up to 3 cm) before surgical removal. Ten people with stage I-II lung cancer will receive the ablation during a bronchoscopy, and the treated tissue…

This study tests whether adding raloxifene to the standard drug finasteride works better than finasteride alone for men with an enlarged prostate (BPH). About 242 adults will take either the combo or finasteride plus a placebo for 12 months. The goal is to see if the combo improv…

This study tests whether the drug epcoritamab can help people with follicular lymphoma who still have signs of cancer after their first round of chemoimmunotherapy. About 35 adults with advanced-stage disease will receive epcoritamab as a second treatment. The main goal is to see…

This study tests whether a short course of the steroid hydrocortisone can reduce inflammation and improve outcomes for people with severe pancreatitis. Researchers will give the drug or a placebo to 86 ICU patients and track their organ failure scores and hospital stay length. Th…

This study compares two ways of managing heart devices like pacemakers and defibrillators: one uses remote alerts to guide care, the other follows standard guidelines. Researchers will enroll 120 adults with wireless devices to see if the alert-based approach is safe and effectiv…

This study tests whether delivering healthy DASH-diet groceries and dietitian support to people with high blood pressure in Florida, Georgia, and Tennessee can lower their blood pressure. About 150 adults with elevated blood pressure will receive all their groceries for 4 weeks. …

This pilot study is testing whether combining a blood patch (using the patient's own blood) with a small valve can safely and effectively seal persistent air leaks in the lungs. These leaks often happen after lung surgery or injury and can lead to long hospital stays. The study w…

This study is testing whether a thin wire that measures blood flow in heart arteries can help doctors decide which blockages truly need a stent. About 107 people with severe-looking blockages will have the wire test before and after stent placement. The goal is to see if some blo…

This study is testing whether regular screening with endoscopic ultrasound (EUS) or MRI can find early signs of pancreatic cancer in people at high risk. About 1,395 participants will be screened, and researchers will track how many have high-risk lesions that can be treated. The…

This study is testing a handheld device called mScan that uses a tiny, painless electrical current to measure muscle health. Researchers want to see if it can give similar results to an MRI, but faster and more conveniently. The study involves 150 adults with and without muscle d…

This study tests a simple program for people aged 60+ having heart surgery. Before surgery, participants will get help improving sleep and do brain exercises. After surgery, they receive extra pain relief. The goal is to see if this bundle reduces delirium (sudden confusion and a…

This study tests whether injecting a small amount of saline into the spinal fluid can quickly reverse leg weakness caused by spinal anesthesia after joint replacement surgery. About 20 adults having elective lower extremity joint replacement will receive the saline through a tiny…

This study tests whether using a CPAP machine during a 6-minute walk test helps people with excessive central airway collapse (ECAC) walk farther and feel less breathless. ECAC is a condition where the central airways narrow or collapse during breathing, making exercise difficult…

This study tests whether mind-body techniques can help people with chronic back pain feel better and move more easily. Researchers will compare two different mind-body programs to usual care in 150 adults. The goal is to see if these approaches reduce pain-related disability and …

This small study tests a mind-body intervention for people with chronic migraines. Ten adults with frequent headaches will attend educational sessions and get personalized coaching. The goal is to see if the program is feasible and whether it can reduce migraine-related disabilit…

This pilot study tests whether using a pelvic wand for perineal massage in late pregnancy and during labor can help women feel more in control and reduce pelvic injuries. Researchers will enroll 140 pregnant women at Beth Israel Deaconess Medical Center. Participants will either …

This study tests a new rehabilitation method for people who lost part of their vision after a stroke. It combines gentle electrical brain stimulation with visual exercises, sometimes using virtual reality, to try to speed up recovery of sight in the blind area. The study involves…

This study tests whether using ultrasound to guide a numbing injection (hematoma block) works better than the traditional method of injecting without imaging for people with a broken wrist. About 115 adults in the emergency department will take part. The goal is to see which appr…

This study looks at whether dry needling can reduce pain from trigger points (tight, tender spots) in the trapezius muscle, which runs from the neck to the shoulders. About 70 adults with myofascial pain will receive either dry needling or a placebo treatment. Researchers will us…

This study tests whether a 13-week mind-body program can help people with chronic wrist, elbow, or shoulder pain from repetitive stress. Participants attend twice-weekly sessions for the first month, then weekly sessions, learning techniques to reduce pain and improve arm functio…

This study tests whether a mind-body intervention, including educational sessions and personalized support, can reduce long COVID symptoms like pain, fatigue, and dizziness. Researchers will compare it to usual care and another mind-body program in 180 adults. The goal is to see …

This study tests a medicated foam (roflumilast) applied to the skin for hidradenitis suppurativa, a condition causing painful bumps and abscesses. About 20 adults with mild to moderate HS will use the foam for 16 weeks. The goal is to see if it reduces the number of inflamed nodu…

This study tests whether letting men control their own nitrous oxide (laughing gas) during a vasectomy can lower pain and anxiety. About 35 men scheduled for a vasectomy will use a mask to adjust their gas level as needed. The goal is to see if this approach improves comfort and …

This study tests a hat that shines infrared light on the head for 30 minutes each day. The goal is to see if it can safely reduce seizures in people with drug-resistant epilepsy. Thirteen adults will try it for six months, and researchers will track seizure changes and comfort.

This study tests a new approach to improve sleep in people aged 60+ with mild cognitive impairment (MCI). It combines a gentle brain stimulation technique called TMS with an internet-based sleep therapy program. The goal is to see if this combo can ease insomnia and possibly boos…

This study tests a program called Doula Link, which gives doulas extra training and tools to support the mental health of pregnant and new mothers. Researchers will compare doulas who receive this training to those who continue their usual care. The goal is to see if the program …

This study tests whether a technique called high-definition transcranial direct current stimulation (HD-tDCS) can improve word-finding difficulties in people who had a traumatic brain injury at least a year ago. The device delivers a very low electrical current through electrodes…

This study looks at how a natural brain chemical called allopregnanolone affects mood and thinking in women going through menopause. Researchers want to understand why some women feel depressed during this time. The study involves 80 healthy women aged 40 to 60 who have depressiv…

This study will explore whether sleep apnea makes multiple sclerosis worse. Researchers will collect sleep studies, MRIs, and lab results from 800 adults with MS to see if there is a link. The goal is to better understand how sleep problems might affect the brain and overall heal…

This study is testing a device called the mScan to see if it can track how ALS progresses over time. Researchers will measure electrical signals in muscles and compare them to standard tests. The goal is to find a simple, objective way to monitor the disease that could be used at…

This study looks at how getting only 4 hours of sleep for three nights, or having insomnia, changes the way people process and control their emotions. Researchers will use brain scans and behavioral tests to compare these groups with people who sleep normally. The goal is to bett…

This study is looking at whether early signs of inflammation in the blood can help identify which patients with infections are at risk for serious complications like sepsis. Researchers will follow 4,200 adults with confirmed or suspected infections, as well as healthy controls, …

This study follows 500 people with early Alzheimer's who are receiving anti-amyloid antibody therapy (like lecanemab) in routine care. Researchers will compare their cognitive decline to historical data and track side effects. The goal is to learn how well these drugs work in the…

This study screens healthy adults aged 18 and older to see if they qualify for future infectious disease research at Beth Israel Deaconess Medical Center. It collects basic information like race, ethnicity, and gender, and tracks how many screened volunteers later join other stud…

This study tests whether a decision aid and training for surgeons can help women aged 70 and older with low-risk stage I breast cancer make better treatment choices. About 402 participants will be split into two groups: one where surgeons get shared decision-making training and p…

This study looks at whether transferring embryos after 3 days or 5 days leads to more live births in IVF patients who have 5 or fewer embryos. About 1,126 people will take part, and researchers will also track patient satisfaction and complications. The goal is to help doctors an…

This study looks at why postmenopausal women have a higher risk of diastolic heart failure. Researchers will examine heart tissue from 500 patients undergoing cardiac surgery to study how estrogen loss affects heart energy and blood vessel health. The goal is to better understand…

This study uses special imaging to map the lymphatic system in the arms of healthy women and breast cancer survivors who did not develop swelling (lymphedema). The goal is to learn how these alternate pathways work and why some people avoid lymphedema after lymph node removal. Ab…

This study tests whether a simple fetal ECG monitor worn at home can effectively track the health of babies in high-risk pregnancies. Fifty pregnant women who need weekly fetal testing will use the device for 30-minute sessions, three times a week, starting at 32 weeks. The goal …

This study looks at 320 people with early psychosis to see if brain scans, eye-tracking, and electrical brain waves can predict how well they respond to treatment. Participants will have four visits over a year, including interviews, memory tests, and optional DNA samples. The go…

This study tests if low-cost, single-use bronchoscopes (thin tubes used to look inside the lungs) can safely replace reusable ones for routine lung procedures. About 20 adults will undergo a lung exam with the disposable scope. Doctors will rate the scope's quality, handling, and…

This early-phase study looks at how heat stress changes kidney function in 28 healthy, fit volunteers. Researchers want to understand the body's chemical responses and whether taking vitamin B3 (niacinamide) can influence those changes. The goal is to gather knowledge, not to tre…

This study looks at brown fat, a type of body fat that burns energy to produce heat, and compares it to white fat, which stores energy. Researchers will collect fat samples from 40 healthy adults during planned surgeries and analyze them to understand how brown fat works. The goa…

This study aims to understand why some men with an enlarged prostate (BPH) do not respond to the common drug finasteride. Researchers will follow 120 men starting finasteride, tracking their symptoms and using MRI scans and genetic tests over three years. The goal is to find ways…

This observational study is testing whether non-invasive monitors that track brain electrical activity and oxygen levels can help determine the best blood pressure to maintain during major non-cardiac surgery in people over 60. The goal is to see if these monitors can reliably gu…

This study looks at how quickly the stomach empties in women during early labor when they drink either water or a sports drink. It includes women with and without epidural pain relief. The goal is to understand digestion during labor, not to test a treatment.