Brain chemical study seeks clues to menopause depression

NCT ID NCT06238700

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This study looks at how a natural brain chemical called allopregnanolone affects mood and thinking in women going through menopause. Researchers want to understand why some women feel depressed during this time. The study involves 80 healthy women aged 40 to 60 who have depressive symptoms. Participants will take a supplement called pregnenolone and complete questionnaires and tasks to measure changes in mood and behavior.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Beth Israel Deaconess Medical Center

    RECRUITING

    Boston, Massachusetts, 02215, United States

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