Beth Israel Deaconess Medical Center

Sepsis damages the protective lining of blood vessels, leading to organ failure and death. This study tests whether giving fresh frozen plasma—either as short infusions or continuously—can repair that lining better than a placebo fluid. About 45 adults with sepsis in the ICU will…

This study tests whether using alerts from pacemakers and defibrillators to guide care is as safe and more effective than following standard schedules. About 3,000 adults with wireless heart devices will be randomly assigned to either alert-driven care or guideline-based care. Th…

This study tests a special microscope that lets surgeons check for leftover cancer cells right after removing the prostate. It involves 20 men with prostate cancer who are already scheduled for surgery. The goal is to see if the microscope can accurately find cancer at the edges …

This pilot study will test whether an iPad app called DCog Short can spot early signs of brain-related side effects (neurotoxicity) in 40 adults receiving CAR-T cell therapy for blood cancers. Participants will use the app to self-report symptoms, and researchers will compare the…

This trial tests whether a single high dose of nicotinamide (a form of vitamin B3) taken on the morning of heart surgery can reduce the risk of acute kidney injury afterward. The study enrolls 20 adults undergoing coronary bypass or valve surgery with a heart-lung machine who are…

This study explores whether easy-to-learn breathing exercises and guided meditations can reduce stress, anxiety, and depression in elderly ICU survivors and their caregivers. Fourteen pairs (survivor and caregiver) will practice Isha Kriya meditation and Nadi Shuddhi breathing fo…

This trial investigates whether the volume and concentration of medication given through an epidural affect how well it relieves labor pain and what side effects occur. Pregnant women at 36 weeks or more, in early labor or being induced, receive the same dose of bupivacaine and f…

This study tests whether giving high-flow nasal oxygen before, during, and after robotic surgery can prevent oxygen drops and lung complications. About 190 adults having robotic surgery will be randomly assigned to receive either high-flow oxygen or standard care. The goal is to …

This study tests whether a short, daily, app-based meditation called Miracle of Mind can help young adults feel better, less stressed, and more resilient. About 354 people aged 18-40 in the US will be randomly assigned to do the meditation, listen to a neutral audio lesson, or co…

This study looks at whether adding a short daily guided meditation practice to mindfulness education can improve how engaged and well employees feel at work. About 134 adult workers will use a smartphone app and complete surveys over 12 weeks. The goal is to see if the combined a…

This pilot study investigates how standard changes to mechanical ventilator settings—such as breath size, flow rate, and pressure—affect shortness of breath in awake patients on ventilators. Many ICU patients experience breathlessness despite sedation, which may contribute to PTS…

This study looks at how irregular sleep and certain types of lighting affect thinking skills and brain health. Researchers will monitor 40 healthy adults aged 18-40 to measure changes in sleep, mental performance, and brain chemistry. The goal is to understand these connections, …