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Tweaking ventilator settings could ease breathlessness and cut PTSD risk in ICU survivors

NCT ID NCT07701850

Not yet recruiting Knowledge-focused Sponsor: Beth Israel Deaconess Medical Center Source: ClinicalTrials.gov ↗

First seen Jul 14, 2026 · Last updated Jul 15, 2026 · Updated 1 time

Summary

This pilot study investigates how standard changes to mechanical ventilator settings—such as breath size, flow rate, and pressure—affect shortness of breath in awake patients on ventilators. Many ICU patients experience breathlessness despite sedation, which may contribute to PTSD after recovery. By testing safe adjustments in 20 patients, researchers aim to identify settings that improve comfort and reduce long-term mental health problems.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
standard ventilator setting adjustments (tidal volume, flow, PEEP, mode changes)
What this could lead to
If successful, this study could point toward ventilator strategies that reduce shortness of breath and lower the risk of PTSD in survivors of severe respiratory failure.
What could go wrong
This is a very small pilot study (20 patients) that only measures short-term changes in dyspnea. Results may not apply to all ventilated patients or lead to clear clinical recommendations.

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Conditions

The condition(s) this trial relates to.

Dyspnea respiratory failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DYSPNEA DURING MECHANICAL VENTILATION MECHANICAL VENTILATION RESPIRATORY FAILURE

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Beth Israel Deaconess Medical Center

    Boston, Massachusetts, 02215, United States

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