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Can tilting a Patient's body toward the infection help them breathe free sooner?

NCT ID NCT07821710

Symptom relief Sponsor: Affiliated Hospital of Jiangnan University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 16, 2026 · Last updated Sep 17, 2026 · Updated 1 time

Summary

Researchers are testing whether adjusting a patient's body position based on where the lung infection sits, combined with mechanical vibration on the chest, helps clear infected mucus better than routine position changes. The trial enrolls 384 adults in intensive care who need a breathing tube and have a confirmed lung infection. Half receive the imaging-guided positioning plus vibration, and half receive standard position changes with vibration. The main question is whether the targeted approach shortens the time patients need the breathing machine.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Imaging-guided postural drainage combined with mechanical vibration chest physiotherapy
What this could lead to
If it works, this could give ICU teams a simple, low-cost way to help ventilated patients clear lung infections and spend less time on a breathing machine.
What could go wrong
The approach may not shorten time on a ventilator, and repositioning very sick patients carries risks such as unstable blood pressure or dislodged tubes. Results from one hospital may not apply everywhere.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

384 people

The number who actually took part.

Started

May 2022

Finished

Oct 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Aged 18-80 years old; 2. Admitted to ICU and receiving invasive mechanical ventilation; 3. Clinically confirmed pulmonary infection; 4. Enrolled between May 2022 and October 2024. Exclusion Criteria: 1. Unstable systemic disease contraindicating postural changes; 2. Active bleeding (gastrointestinal, intracranial, or pulmonary); 3. Requirement for continuous renal replacement therapy; 4. Raised intracranial pressure; 5. Neuromuscular disorder; 6. Multiple fractures or major trauma; 7. Severe hemodynamic instability; 8. Significant arrhythmias; 9. Severe delirium or altered mental status; 10. Pregnancy or lactation; 11. Currently participating in another interventional clinical trial.

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Conditions

The condition(s) this trial relates to.

respiratory failure respiratory tract infectious disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Mechanical ventilation Pulmonary infection Respiratory failure

Contacts and locations

Locations

  • Wuxi Taihu Hospital

    Wuxi, Jiangsu, 214003, China

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