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Can a bedside ultrasound predict which septic shock patients will stop breathing on their own?

NCT ID NCT07820267

Knowledge-focused Sponsor: Assiut University Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
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Paused for now. It may or may not start again.
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Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

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Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

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Status unknown
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First seen Sep 15, 2026 · Last updated Sep 16, 2026 · Updated 1 time

Summary

Researchers are studying whether repeated bedside ultrasound scans of the diaphragm can predict breathing failure in adults with septic shock. The study follows 120 patients in intensive care for up to 72 hours, measuring how far the diaphragm moves and how thick it is. The team will compare these measurements with outcomes such as the need for a breathing tube, time on a ventilator, length of ICU stay, and survival. The goal is to see whether a simple, non-invasive scan can give doctors an early warning about which patients are most at risk.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
bedside point of care ultrasound assessment of diaphragm function
What this could lead to
If the approach works, doctors could use a quick bedside ultrasound to spot septic shock patients whose breathing is about to fail and start treatment sooner.
What could go wrong
This is an observational study, so it can show a link between diaphragm changes and outcomes but cannot prove that acting on those changes helps patients. Results from one hospital may not apply everywhere.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 120 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Oct 2026

An estimate. Start dates often move.

Expected to finish

Jun 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population will consist of adult patients 18 years old or more admitted to ICU with septic shock diagnosed according to the sepsis-3 criteria. Eligible patients will be prospectively enrolled after meeting the predefined inclusion and exclusion criteria and will undergo serial bedside point of care ultrasound assessment of diaphragmatic function during the first 72 hours of ICU admission.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 18 years old. * Patients with septic shock. * Patients with ICU admission during study period. * Expected ICU stay for at least 72 hours. * Informed consent from the patient or legal guardian when required. Exclusion Criteria: * Age less than 18 years old. * Pre-existing neuromuscular disorders affecting respiratory muscles. * Known diaphragmatic paralysis or diaphragmatic palsy. * Significant phrenic nerve injury. * Cervical spinal cord injury. * Advanced chronic neuromuscular disease. * Previous major thoracic or diaphragmatic surgery. * Severe chest wall deformity. * Conditions preventing adequate diaphragmatic ultrasound assessment. * Pregnancy, if required by local ethical policy. * Patients with limitations of care that preclude full respiratory support. * Refusal of consent where consent is required.

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Conditions

The condition(s) this trial relates to.

diaphragm disorder respiratory failure toxic shock syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Diaphragmatic dysfunction Mechanical ventilation Respiration failure Septic shock

How to take part

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  1. The places running it

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  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Faculty of medicine, Assiut university

    Asyut, 71515, Egypt

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