SEPTIC SHOCK

This study tests if giving methylene blue early can improve blood flow in patients with septic shock. It includes 50 adults who still have low blood pressure after fluids. The main goal is to see if a larger trial is possible, not to prove the drug works yet.

This study tests whether giving two steroids (hydrocortisone and fludrocortisone) together can lower the risk of death in adults with septic shock, a life-threatening condition. About 336 patients will be randomly assigned to receive the combo or standard care. The main goal is t…

This study is collecting real-world data from 200 adults with sepsis or septic shock who receive ARTICE® therapy in the ICU. Researchers will track organ function, lab markers, survival, and complications to better understand how well the treatment works and who benefits most. Th…

This study tests whether giving angiotensin II early in the emergency department can help treat septic shock, a life-threatening drop in blood pressure due to infection. Twenty adults who need blood pressure support will receive the drug through a vein. The goal is to see if this…

This study tests if giving a drug called norepinephrine early and adjusting the dose quickly can help adults with septic shock survive longer. Septic shock is a life-threatening drop in blood pressure due to infection. About 600 adults will either get the drug early or standard c…

This study tests whether a personalized treatment with Pentaglobin (a mix of antibodies) can improve recovery in people with severe abdominal infection (peritonitis) that has led to sepsis or septic shock. About 200 adults will receive either standard care or standard care plus P…

This early study tests whether draining lymph fluid from the chest can lower harmful inflammation in people with septic shock. Ten adults in the surgical ICU will have a tube placed in their thoracic duct to drain lymph for up to 7 days. The goal is to see if this approach is saf…

This study tests whether giving fewer IV fluids (other than those needed for emergency resuscitation) to adults with septic shock leads to better outcomes compared to usual care. The main goal is to see if this approach reduces deaths. The trial will enroll 1,850 participants in …

This study tests whether using a measure called the CO2 gap to guide early treatment of septic shock can reduce deaths more than the usual method of tracking lactate levels. Septic shock is a life-threatening condition where blood flow to tissues is poor. The trial will enroll 75…

This study looks at 240 adults in septic shock who develop a new irregular heartbeat. It compares three approaches: controlling heart rate with low-dose amiodarone, restoring normal rhythm with high-dose amiodarone or electric shock, or managing risk factors without antiarrhythmi…

This study tests whether giving the drug vasopressin earlier or later helps adults with septic shock. Researchers will use a computer tool to randomly assign 300 ICU patients to one of two timing strategies. The goal is to see if early use reduces the need for other strong blood-…

This study compares two types of IV fluids—sodium lactate and 3% saline—in 40 adults with septic shock. The goal is to see which fluid better supports heart function and balances acid levels in the blood. Participants will receive one of the fluids during standard care, and resea…

This study tests whether stimulating a nerve in the ear (vagus nerve) can reduce inflammation and improve heart function in people with septic shock, a life-threatening condition. About 34 participants will receive either active or sham stimulation for 4 hours, alongside standard…

This study compares two ways of treating dangerously low blood pressure in people with sepsis. One group gets the standard drug norepinephrine plus early vasopressin, while the other gets vasopressin only if needed as a rescue. The goal is to see if early use of vasopressin reduc…

This study looks at whether giving the steroid hydrocortisone to children with septic shock (a life-threatening infection that causes very low blood pressure) can prevent new or worsening organ failure. About 500 children in intensive care will receive either hydrocortisone or a …

This study looks at whether a special filter called oXiris helps people with septic shock and kidney failure survive. Researchers will compare patients who got the oXiris filter with those who got standard filters during blood cleaning. The goal is to see if the oXiris filter red…

This study compares two medicines, adrenaline and dopamine, to see which works better for children with a severe blood infection called septic shock that doesn't improve with fluids. The trial will include 90 children aged 1 month to 12 years and check things like blood pressure,…

This study looks at whether a machine called ECMO can help children with severe septic shock who are not getting better with standard treatment. ECMO works as an artificial heart and lung to support the body. The study will include 60 children and aims to see if ECMO improves sur…

This study tests whether using a device that measures blood flow in the finger (called the Peripheral Perfusion Index, or PPI) to guide fluid treatment can prevent acute skin failure in elderly patients in the intensive care unit (ICU). About 216 patients aged 65 and older with s…

This study compares a combination of two sedatives (propofol and ketamine) against propofol alone in elderly ICU patients who need a breathing tube. The goal is to see if the combo reduces dangerous drops in blood pressure. The trial involves 41 patients aged 65 or older with hea…

This study looks at how well two different software programs measure heart function in people with septic shock, a life-threatening condition. Researchers will use existing heart ultrasound data from 60 adult patients to compare the measurements and see if they are consistent. Th…

This study observes about 1,950 patients with suspected sepsis in the emergency department. Researchers will analyze blood samples to see how well certain markers (like calprotectin) and rapid DNA tests can detect infections. The goal is to better understand sepsis and move towar…

This study looks at whether being frail (measured by a simple scale) increases the risk of death in adults aged 18 to 65 admitted to intensive care for septic shock. Researchers will follow 200 patients to see if frailty is linked to death within 28 and 90 days, longer hospital s…

This study looks at 40 adults with septic shock to see if measuring blood flow in the neck (carotid artery) is as good as a heart ultrasound for deciding how much fluid to give. Only about half of patients respond to fluids, so better guidance could improve care. The goal is to f…

This study looks at the best way to stop the drug vasopressin in adults with septic shock who are in the ICU. It compares slowly reducing the dose versus stopping it all at once. The goal is to see which method causes fewer dangerous drops in blood pressure. About 82 people will …

This study watches how doctors use vasopressin (a blood pressure drug) in adults with septic shock in the ICU. It aims to see if starting it earlier helps more people survive and protects kidney function. No new treatment is given—just careful observation of real-world care.

This study tests whether using a bedside heart ultrasound (POCUS) to guide fluid and medication decisions improves outcomes for 140 adults with liver cirrhosis and severe sepsis or septic shock. Participants will be randomly assigned to POCUS-guided care or standard guideline-bas…

This study looks at how much antibiotic is removed when ICU patients with septic shock and kidney failure receive blood-cleaning treatments. Twenty adults will have their antibiotic levels checked before and after the blood passes through the cleaning cartridges. The goal is to h…

This study looks at whether adding specific nutrients to blood cells from septic shock patients can fix the cells' energy centers (mitochondria). Researchers will take blood samples from 55 adults in the ICU and test these nutrients in the lab. The goal is to understand if this a…

This study observes 120 adults with septic shock in the ICU to understand how their metabolism changes when given fluids. Researchers will measure oxygen use and organ function to find patterns that could guide better treatment. The goal is to learn, not to test a new drug or cur…

This study looks at a serious condition called mixed cardiogenic-vasoplegic shock, where the heart fails to pump and blood vessels widen too much. Researchers will review medical records from 2,500 adults in French hospitals to learn who is at risk and what affects survival. No n…

This study looks at two methods—using ultrasound to measure the main vein in the belly and using a special heart monitor—to predict which patients with septic shock need more fluids. The goal is to give the right amount of fluid to each person, avoiding both too little and too mu…

This study looks at whether a special blood gas measurement (PvCO2-PaCO2/CaO2-CvO2) can help predict which patients with septic shock are more likely to survive. Researchers will measure this ratio in 30 adults during the early phase of septic shock and compare it to standard lac…

This study aims to find biological markers that can predict whether sepsis will progress to septic shock, a life-threatening condition. Researchers will compare epigenetic markers in blood samples from 25 male patients aged 45-75 who develop sepsis after major digestive cancer su…

This study is a large registry that collects data on how a blood-filtering device called CytoSorb is used in real-world intensive care settings. It will include up to 3,000 critically ill patients with conditions like septic shock, severe lung injury, or liver failure. The goal i…

This study looks at whether a protein called vasorin in the blood can help doctors tell the difference between septic shock (caused by infection) and other types of shock. Researchers will measure vasorin levels in 144 intensive care patients and compare them with standard tests.…

This study is looking for new ways to quickly diagnose sepsis, a life-threatening reaction to infection, in the emergency room. Researchers will study the immune responses of 3,300 adults with suspected infections to find patterns that signal sepsis. The goal is to improve early …

This study looks at using a computer program (machine learning) to help doctors diagnose sepsis and septic shock more quickly. Researchers will analyze data from 10,000 ICU patients to see if the algorithm can spot warning signs earlier than current methods. The goal is to speed …

This study aims to see if a program that includes guidelines, feedback, and education can reduce the use of vancomycin (a strong antibiotic) in children with suspected sepsis in intensive care units. About 52,500 children will be involved across five hospitals. The goal is to low…

This study aims to understand how long a special dialysis filter (Oxiris®) effectively removes harmful toxins from the blood of adults with severe septic shock. Researchers will observe 29 patients already receiving this filter as part of their standard ICU care, taking blood sam…