SEPTIC SHOCK

This study tests whether giving a personalized dose of Pentaglobin (an antibody treatment) after surgery helps people with severe abdominal infection (peritonitis) and sepsis recover better. Researchers will enroll 200 patients and track organ failure and survival. The goal is to…

This pilot study tests whether adding fludrocortisone (a steroid pill) to standard hydrocortisone treatment helps people with septic shock. Only 32 critically ill adults will take part. The main goal is not to see if the combo works, but to check if a larger, more definitive tria…

This study tests whether a non-invasive ultrasound device, aimed at the spleen, can safely reduce dangerous inflammation in people with septic shock. Septic shock is a life-threatening condition where the body's response to infection causes organ damage. Forty adults in the inten…

This study tests whether giving the drug norepinephrine early and adjusting the dose quickly can improve survival in adults with septic shock. Researchers will compare this approach to standard care with a placebo. Six hundred participants will be monitored for 28 days to see if …

This study looks at whether a special blood filter called oXiris helps people with septic shock and kidney failure survive. Researchers will review medical records of 360 adults in the ICU who needed continuous blood filtering. They will compare those who got the oXiris filter wi…

This study compares two fluids—sodium lactate and a concentrated saline solution—in 40 adults with septic shock. The goal is to see which one better supports blood flow and acid balance. Participants will receive either fluid in a double-blind setup, and researchers will measure …

This pilot study tests whether a mild electrical pulse to the ear (vagus nerve stimulation) can reduce inflammation and improve heart rate balance in people with septic shock. 34 participants will be randomly assigned to receive either active stimulation or a sham (placebo) for 4…

This study is testing whether giving fewer non-essential fluids to adults with septic shock can improve outcomes. The trial will enroll 1,850 patients in intensive care, comparing a restrictive fluid strategy to usual care. The main goal is to see if this approach reduces deaths …

This study tests if a medicine called methylene blue can help improve blood flow in patients with septic shock, a severe infection that causes dangerously low blood pressure. About 50 adults will receive either methylene blue or standard care for 3 days. The main goal is to see i…

This study tests whether a heart-lung bypass machine (ECMO) can help children with severe septic shock survive. Researchers will enroll 60 children and track how many leave the hospital alive. They also want to find the best time to start ECMO and which factors affect success.

This study tests whether giving the drug vasopressin earlier or later during septic shock leads to better outcomes. Researchers will use a computer alert system to randomly assign 300 ICU patients to early or standard timing. The goal is to see if the timing can be reliably contr…

This pilot study tests whether giving angiotensin II early in the emergency department can help stabilize blood pressure in patients with septic shock. Twenty adults who need a standard drug called norepinephrine will receive angiotensin II as an add-on. The main goal is to see i…

This study tests whether giving two steroids—hydrocortisone and fludrocortisone—for up to 7 days can lower the risk of death in adults with septic shock. About 336 patients will be randomly assigned to receive either the steroid combo or standard care alone. The main goal is to s…

This early study tests whether draining lymph fluid from the chest can lower harmful inflammation in people with septic shock. Ten adults in the surgical ICU will have a tube placed in their thoracic duct to drain lymph for up to 7 days. The goal is to see if this procedure is sa…

This registry study is following 200 adults with sepsis or septic shock who receive ARTICE® therapy in the ICU. Researchers are tracking organ function, survival, and complications to see how well the treatment works in everyday practice. The goal is to identify which patients be…

This study tests whether giving vasopressin early, along with norepinephrine, is better than waiting to use it as a rescue treatment for people with septic shock. About 2,800 critically ill adults will be randomly assigned to one of two strategies. The main goal is to see which a…

This study looks at 240 adults with septic shock who develop a new, fast heart rhythm problem. It compares three treatment approaches: controlling heart rate with low-dose amiodarone, restoring normal rhythm with high-dose amiodarone or electric shock, or managing risk factors wi…

This study compares adrenaline and dopamine to treat a severe type of septic shock in children that doesn't improve with fluids. The goal is to see which drug better improves vital signs like blood pressure, heart rate, and urine output. The trial will include 90 children aged 1 …

This study tests whether giving the steroid hydrocortisone to children with septic shock can prevent new or worsening organ failure. About 500 children in intensive care will receive either hydrocortisone or a placebo for up to seven days. The goal is to see if this treatment imp…

This study tests whether a combination of clinical guidelines, feedback, and education can reduce the overuse of vancomycin in children with suspected sepsis in intensive care units. Over 52,000 patients and many clinicians across five hospitals will take part. The goal is to low…

This study investigates whether a urine test called Nephrocheck can predict which patients with septic shock will develop severe acute kidney injury. The test measures two markers of kidney damage (TIMP2 and IGFBP7). Researchers will analyze data from previous studies involving a…

This study looks at using a computer algorithm to quickly diagnose sepsis and septic shock from routine hospital data. Researchers will analyze information from 10,000 ICU patients to see if the algorithm can speed up diagnosis and improve patient outcomes. The goal is to help do…

This study tests whether using a device that measures blood flow to the skin (called the peripheral perfusion index) can help doctors give fluids more precisely to elderly ICU patients with sepsis or shock. The goal is to prevent acute skin failure, a serious condition where the …

This study compares two sedation methods for elderly ICU patients (65+) who need a breathing tube. One group gets a mix of propofol and ketamine, the other gets propofol alone. The goal is to see which causes fewer dangerous drops in blood pressure. The trial involves 41 particip…

This study compares two methods for guiding early treatment in people with septic shock, a severe infection that can cause organ failure. The standard approach uses blood lactate levels, but this trial tests whether using the CO2 gap (a measure of blood flow) is better at reducin…

This study looks at small molecules called miRNAs in the blood of patients with septic shock. The goal is to understand why some patients develop a weakened immune system after sepsis, which can lead to more infections and higher risk of death. Researchers will compare miRNA patt…

This study is measuring cortisol levels in 183 adults with sepsis or septic shock in the ICU to see if those levels can predict who is at higher risk of dying. Researchers will track deaths in the ICU and at 28 and 90 days. The goal is to help doctors identify high-risk patients …

This study looks at whether frailty—measured by a simple scale—can predict death in adults aged 18 to 65 admitted to intensive care for septic shock. Researchers will track 200 patients to see if those who are frail have a higher risk of dying within 28 days, even after accountin…

This study will check if a new scoring system called SOFA-2 can better predict which ICU patients are likely to die within 30 days, compared to the current standard. Researchers will also measure how common sepsis and septic shock are in Turkish intensive care units. About 2,500 …

This study looks at two different ultrasound techniques to help doctors decide how much fluid to give patients with septic shock. One method measures the heart's left ventricle, while the other checks blood flow in the carotid artery. The goal is to see which is more accurate at …

This study looks at how a blood-filtering cartridge (HA 380) used with continuous kidney dialysis removes antibiotics in ICU patients with septic shock and kidney failure. Researchers will take blood samples before and after the filter at several time points to measure changes in…

This study looks at whether a new blood gas ratio can help predict which patients with septic shock are more likely to survive. Researchers will measure this ratio and compare it to standard lactate levels in 30 adults with septic shock. The goal is to see if the ratio gives earl…

This study is observing about 1,950 emergency patients with suspected sepsis to see if new blood tests (like calprotectin and bacterial DNA tests) can detect infections faster and more accurately than current methods. The goal is to find better ways to diagnose sepsis and tailor …

This study looks at how well the Oxiris blood filter removes harmful toxins in adults with septic shock in the ICU. Researchers will take blood samples before and after the filter over 24 hours to see when it stops working. No new treatment is given—just observation. The goal is …

This study looks at 60 people with septic shock, a severe infection that causes dangerously low blood pressure. Doctors need to give fluids carefully, but too much can be harmful. The trial compares two methods—a heart monitor (cardiometry) and an ultrasound of a large vein (IVC …

This study aims to find epigenetic markers in the blood that could predict whether a patient with sepsis will develop the more dangerous septic shock. Researchers will take blood samples from 25 male patients after major digestive cancer surgery who develop sepsis. By comparing m…

This study looks at a severe condition called mixed cardiogenic-vasoplegic shock, where the heart fails to pump and blood vessels widen too much. Researchers will review medical records from 2,500 patients in three French hospitals to understand who gets this condition and how th…

This study looks at how well two different software programs measure heart function in people with septic shock, a life-threatening infection that affects the whole body. Researchers will use existing heart ultrasound data from 60 adults to see if the measurements agree and can b…

This study is looking at whether a protein called vasorin (Vasn) in the blood can help doctors quickly tell the difference between septic shock (caused by infection) and other types of shock (like after heart surgery). Currently, the best test for this is not always accurate. The…

This study looks at the best way to stop the blood pressure medication vasopressin in people with septic shock. It compares slowly reducing the dose versus stopping it all at once. The goal is to see which method causes fewer dangerous drops in blood pressure. The study involves …

This study watches how doctors use vasopressin, a second blood pressure drug, in adults with septic shock in the ICU. It aims to see if starting it earlier lowers death rates and helps protect kidney function. Researchers will track 1,200 patients to gather real-world data.

This study compares two ways to manage fluids in cirrhosis patients with severe sepsis or septic shock. One method uses a bedside heart ultrasound (POCUS) to guide fluid amounts, while the other follows standard sepsis guidelines. The goal is to see if ultrasound-guided care redu…

This study looks at whether adding certain nutrients to blood cells from people with septic shock can help restore the cells' energy-making machinery (mitochondria). Researchers will collect blood samples from 55 patients in the ICU and test these nutrients in the lab. The goal i…

This observational study is watching how the body's metabolism changes when septic shock patients receive a rapid fluid infusion. Researchers will measure oxygen use and other markers before and after the fluid challenge in 120 adults. The goal is to find patterns that could guid…

This study is looking for new ways to diagnose sepsis, a life-threatening reaction to infection, earlier in the emergency room. Researchers will study the immune responses of 3,300 adults with suspected infections to find patterns that signal sepsis. The goal is to improve diagno…

This registry is tracking 3,000 critically ill patients who receive the CytoSorb blood-filtering device in real-world intensive care settings. The goal is to collect data on how the device is used and whether it relates to patient survival. It covers many conditions like sepsis, …