SEPTIC SHOCK

This study aims to find the best way to dose the antibiotic ceftazidime for critically ill patients in the ICU with severe infections like sepsis. Researchers will test if personalized dosing, adjusted for each patient's kidney function and other factors, is better than the stand…

This is a small pilot study to see if it's possible to run a larger future trial. It tests whether using a bedside ultrasound scan can safely identify which patients with life-threatening septic shock might benefit from a heart-slowing medication called a beta-blocker. Researcher…

This small pilot study aims to see if adding a drug called fludrocortisone to standard treatment helps patients survive septic shock, a deadly condition where infection causes dangerously low blood pressure. The study will involve 32 critically ill patients in intensive care unit…

This study is testing whether a drug called sivelestat can help restore normal blood clotting in ICU patients with septic shock who develop dangerous blood clotting problems. The trial will involve 120 patients who will receive either the drug or a placebo to see if sivelestat im…

This study aims to see if adding a natural blood protein called albumin to standard intensive care improves survival for patients with surgical septic shock. About 304 adult patients in a surgical ICU will be randomly assigned to receive either standard care alone or standard car…

This study aims to see if starting a blood pressure medication called norepinephrine very early in treatment helps adults survive septic shock, a life-threatening condition. Researchers will compare giving the medication quickly with adjusting the dose every 15 minutes to the sta…

This study is testing whether giving the steroid hydrocortisone early in treatment helps children with septic shock recover faster and survive. It will enroll 122 children aged 2 months to 12 years who are admitted to intensive care. The goal is to see if this approach leads to q…

This study is testing if a special blood filter called Oxiris can help adults with septic shock. Septic shock is a life-threatening condition where a severe infection causes organ failure. Researchers will compare patients receiving the Oxiris treatment plus standard care to thos…

This study tests if giving fluids and a blood pressure medication (norepinephrine) together very early can prevent kidney injury in adults with septic shock. Septic shock is a life-threatening infection that can damage organs. Researchers will monitor 100 patients to see if this …

This project tests whether using a standardized 1-hour checklist for treating sepsis can save more lives. It will compare outcomes for about 120 patients treated before and after the new protocol is introduced at a hospital's emergency and intensive care units. The goal is to get…

This study aims to find the best way to give a common type of antibiotic to adults with severe infections (sepsis) in the intensive care unit. It will compare giving the medicine in longer, extended infusions versus the standard shorter, intermittent doses. The goal is to see whi…

This study compares two treatments for septic shock, a life-threatening condition with high mortality. Researchers will test whether giving Angiotensin II works better than the standard treatment (norepinephrine) at stabilizing patients. The trial will also look for better ways t…

This study aims to see if a new, simpler device (Electrical Cardiometry) is as accurate as the current standard method (Echocardiography) for measuring how well the heart is pumping in patients with septic shock. It will involve 100 adult patients with septic shock. The goal is t…

This study aims to better understand how heart and blood vessel problems affect people with severe sepsis. Researchers will observe 400 adults hospitalized with sepsis who need medication to support their blood pressure. They will perform heart ultrasounds, blood tests, and check…

This study aims to understand how two common emergency treatments for septic shock affect heart function. Researchers will use heart ultrasound to measure changes in 180 patients receiving either intravenous fluids or blood pressure medication. The study observes patients already…

This study aims to test whether a new scoring system (SOFA-2) can better predict which ICU patients with sepsis will survive. Researchers will collect routine medical data from 2,500 adult ICU patients across Turkey to compare the new score against the old one. The study will als…

This study aims to create a computer model that predicts which sepsis patients have antibiotic-resistant infections. Researchers will analyze data from 10,000 adult patients with sepsis at a Buenos Aires hospital to identify patterns and risk factors. The goal is to help emergenc…

This study aims to understand how doctors actually treat patients with septic shock, a life-threatening infection complication, in intensive care units. It will observe 5,000 patients to see if current treatment guidelines are being followed and which practices are linked to bett…

This study aims to see if a simple ratio from two common blood tests (urea and creatinine) can track the body's metabolism in patients with septic shock, a severe and life-threatening infection. Researchers will compare this simple ratio to a more complex, specialized machine tha…

This study aims to understand how thyroid and adrenal hormone levels change in ICU patients with septic shock, a severe and often fatal condition. Researchers will measure these hormone levels in 200 patients to see how they relate to the severity of the illness. The goal is to g…

This study aims to see if a new, quick bedside blood test can predict which critically ill patients are most likely to die within 30 days. Researchers will enroll 130 adults in the ICU with severe conditions like sepsis, shock, or major trauma. They will compare the new finger-pr…