SEPTIC SHOCK

This study looks at whether giving extra human albumin (a natural blood protein) to people with surgical septic shock can help them survive. Septic shock is a life-threatening condition from severe infection. The trial will involve 304 adults in intensive care, comparing standard…

This study looks at two medicines that raise blood pressure in people with septic shock, a life-threatening condition. It compares a newer drug, Angiotensin II, to the standard treatment, norepinephrine. The goal is to see which works better and find ways to predict how severe th…

This study tests whether dapagliflozin, a drug usually used for diabetes, can help people with septic shock—a life-threatening condition where blood flow to small blood vessels fails. About 568 adults in intensive care will receive either dapagliflozin or a placebo, alongside sta…

This study tests a blood purification filter called Oxiris in adults with septic shock, a severe infection that can cause organ failure. Researchers want to see if it lowers the risk of death or organ damage within the first week. Participants will receive the treatment for up to…

This study looks at whether giving hydrocortisone early can help children with septic shock survive and recover faster. About 122 children, ages 2 months to 12 years, will be treated in the ICU. Researchers will measure death rates and how long kids need blood pressure support an…

This study tests whether giving a calming drug called dexmedetomidine early can help people with septic shock. The drug aims to calm an overactive nervous system, reduce organ damage, and improve survival. About 168 adults will receive either the drug or a placebo for 48 hours, a…

This study tests whether a new set of steps for treating sepsis can help patients get the right care faster. Researchers will compare outcomes for 120 adults treated before and after the new protocol is introduced. The goal is to give key treatments like antibiotics and fluids wi…

This pilot study tests whether using ultrasound to guide beta-blocker therapy is feasible in 100 adults with septic shock, a life-threatening infection causing low blood pressure and rapid heart rate. Participants will receive either the beta-blocker esmolol or standard care to s…

This study looks at whether giving fluids and a blood-pressure-raising medicine (norepinephrine) early can prevent acute kidney injury in adults with septic shock. About 100 participants will receive this combined treatment in the ICU or emergency room. The goal is to see if this…

This study tests a drug called sivelestat in 120 adults with septic shock and blood clotting problems. The drug aims to restore the body's ability to break down small blood clots, which may reduce organ damage. Participants will receive either sivelestat or a placebo, and researc…

This study tests whether adding fludrocortisone to the usual steroid treatment (hydrocortisone) can help control septic shock better. It is a small pilot trial with 32 critically ill adults in the ICU. The main goal is to see if a larger, more definitive study is possible, not ye…

This study aims to find the best way to give the antibiotic ceftazidime to patients in intensive care with serious infections. Standard dosing often fails to reach effective levels in 40-60% of patients. The researchers will test a personalized dosing plan based on each patient's…

This study looks at whether a blood gas measurement (the difference in carbon dioxide between central veins and arteries) can accurately detect low cardiac output in patients with septic shock from severe skin infections. Researchers will test this during hyperbaric oxygen therap…

This study looks at 50 adults with sepsis or septic shock in the ICU to see if giving beta-lactam antibiotics over a longer period (extended infusion) works better than giving them all at once (intermittent dosing). The main goal is to check survival rates at 90 days and how well…

This study looks at whether muscle measurements from a CT scan taken when a patient enters the ICU can help predict who will survive for 3 months after leaving the ICU. Researchers will study 196 adults with septic shock. The goal is to see if muscle size and quality are linked t…

This study looks at whether a new rapid blood test, done right at the patient's bedside, can help predict which critically ill patients are at higher risk of dying within 30 days. The test measures a substance called nucleosomes in the blood. Researchers will compare this quick t…

This study looks at whether a simple blood test (urea-to-creatinine ratio) can help doctors track how the body's metabolism changes in patients with septic shock. Septic shock causes the body to break down protein too fast, and knowing when this changes could guide better nutriti…

This study looks at how the thyroid and adrenal glands work in 200 ICU patients with septic shock, a life-threatening infection that causes organ failure. Researchers will measure hormone levels in the blood to see if gland problems are common. No treatment is given—the goal is s…

This study observes 400 adults with sepsis and unstable blood pressure to see how their heart and blood vessels respond. Participants will have heart ultrasounds, blood tests, and blood flow checks within 72 hours of hospital admission. Researchers will track survival for one yea…

This study will compare two noninvasive methods—electrical cardiometry and echocardiography—for measuring how well the heart pumps blood in people with septic shock. Researchers want to see if the simpler electrical method can be a reliable alternative to ultrasound. The study wi…

This study watches how the heart responds to two common treatments for septic shock: IV fluids and blood-pressure-raising medications (vasopressors). Researchers will use heart ultrasounds before and after treatment to see which approach works better. The study involves 180 adult…

This study aims to create a predictive model that helps emergency doctors quickly identify which sepsis patients are likely to have drug-resistant infections. By analyzing data from 10,000 adults treated for sepsis or septic shock, researchers hope to improve antibiotic choices a…

This study will watch and record how doctors treat septic shock in 5000 adult patients across many intensive care units. It aims to see if hospitals follow published guidelines and what factors affect treatment choices. The goal is to understand current practices and find ways to…

This study aims to see if a new scoring system called SOFA-2 can better predict which intensive care patients are at risk of dying within 30 days. Researchers will also measure how common sepsis and septic shock are in Turkish ICUs. About 2,500 adult patients will have their rout…