SEPTIC SHOCK

This study tests whether special blood purification devices can help people with septic shock, a life-threatening condition where infection causes organ failure. The trial includes adults aged 18 to 80 with severe septic shock. Depending on their level of endotoxins, patients rec…

This study tests whether a drug called Angiotensin II works better than the usual treatment (norepinephrine) for people with septic shock, a life-threatening condition where blood pressure drops dangerously. About 78 adults with septic shock will receive either Angiotensin II or …

This Phase 2 trial tests whether adding the drug nogapendekin alfa inbakicept (NAI) to standard sepsis care can improve survival in critically ill adults with sepsis and persistently low lymphocyte counts (a sign of immune suppression). About 50 participants will be randomly assi…

This study tests whether dapagliflozin, a drug used for diabetes, can help people with septic shock—a severe infection that causes organ failure. The drug aims to protect blood vessels and reduce inflammation. About 568 ICU patients will receive either dapagliflozin or a placebo,…

This study tests whether giving the sedative dexmedetomidine early to adults with septic shock can calm their overactive nervous system and improve survival. 168 participants will receive either the drug or a placebo for 48 hours, with close monitoring of heart function, inflamma…

This study will test whether a standardized set of emergency steps—including early screening, blood tests, fluids, and antibiotics—can improve survival for sepsis patients. Researchers will compare outcomes for 120 adults treated before and after the new protocol is introduced. T…

This study tests whether giving intravenous fluids and a blood-pressure-raising drug (norepinephrine) together early can prevent acute kidney injury in adults with septic shock. Researchers will treat 100 patients in the ICU or emergency department and monitor kidney function and…

This study looks at two methods of giving beta-lactam antibiotics to patients with sepsis or septic shock in the ICU: a slow 4-hour infusion versus a quick 30-minute infusion. Researchers will track survival at 90 days and whether the infection clears within 14 days. The goal is …

This study tests a blood purification filter called Oxiris in adults with septic shock and organ failure. Researchers want to see if it lowers the risk of death or worsening organ function within 7 days. Participants will receive the filter treatment for up to 3 days in the ICU a…

This pilot study tests whether using ultrasound to guide treatment with the beta-blocker esmolol is feasible in patients with septic shock. Septic shock is a life-threatening condition where infection causes very low blood pressure and a dangerously fast heart rate. The trial wil…

This study tests whether giving extra human albumin—a natural blood protein—along with standard care can help people survive septic shock after surgery. Septic shock is a life-threatening condition where infection causes dangerously low blood pressure. The trial will enroll 304 a…

This study tests whether sivelestat, a drug used in Japan for lung injury, can help restore the body's ability to break down harmful blood clots in people with septic shock. About 120 adults with septic shock and early blood clotting problems will receive either sivelestat or a p…

This study aims to validate a new blood test that uses artificial intelligence to detect disseminated intravascular coagulation (DIC) early in patients with septic shock. DIC is a severe clotting disorder that often leads to death, but current diagnostic methods are complex and r…

This study will test whether a new, continuous method of measuring heart function (using pressure waves) matches the current standard method (thermodilution) in 43 ICU patients with septic shock. Both methods use the same catheter already placed for treatment. The goal is to see …

This study looks at whether a blood gas measurement (the difference in carbon dioxide between central venous and arterial blood) can accurately diagnose low cardiac output in patients with septic shock from severe skin infections. About 74 adults will be monitored during hyperbar…

This study looks at how sepsis affects the bone marrow, where immune cells are made. Researchers will compare bone marrow samples from 45 people: those with sepsis, other critically ill patients, and healthy volunteers. The goal is to understand why sepsis can weaken the immune s…

This study looks at how esmolol, a drug that slows the heart rate, affects the smallest blood vessels in people with septic shock—a severe infection that can lead to organ failure. Researchers will measure changes in blood flow under the tongue and other key pressures in the circ…

This study looks at how the sedative dexmedetomidine affects the smallest blood vessels in people with septic shock, a life-threatening condition caused by severe infection. Researchers will measure blood flow in the tongue's tiny vessels and other key blood pressure indicators b…

This study tests whether the drug papaverine can improve blood flow in the smallest blood vessels of people with septic shock. Septic shock causes widespread inflammation and poor circulation, which can damage organs. The trial will give papaverine intravenously to 20 adults in t…

This pilot study will test a drug called anisodamine in 20 adults with septic shock who are on a ventilator. The goal is to see if the drug can improve blood flow in small blood vessels and help with a phenomenon called 'vascular waterfall.' This is a very early study to gather i…

This small pilot study tests whether a Chinese herbal medicine called Shenfu Injection can improve blood flow in people with septic shock, a life-threatening condition. Twenty adults in the ICU will receive the injection, and doctors will measure changes in circulation and oxygen…

This study looks at whether measuring the fluorescence of certain white blood cells (neutrophils) can help doctors quickly identify sepsis patients at risk of severe complications like organ failure or septic shock. Researchers will analyze blood samples from 492 adults in the em…

This study looks at whether muscle measurements from a CT scan taken when a patient is admitted to the ICU for septic shock can predict their risk of dying within 3 months after leaving the ICU. Researchers will analyze muscle size, density, and fat content from the scan and comp…

This study will observe the real-world treatment of 5,000 adults with septic shock in intensive care units across many countries. Researchers want to see how closely doctors follow official guidelines and what factors influence their choices. The goal is to identify gaps in care …

This observational study will look at 400 adults with sepsis and unstable blood pressure to understand how their heart and blood vessels are affected. Researchers will use ultrasound and blood tests to classify patients into different groups based on their heart and blood vessel …

This study will use echocardiograms (heart ultrasounds) to see how the heart responds to two common treatments for septic shock: intravenous fluids and vasopressors (medicines that raise blood pressure). Researchers will measure changes in heart function before and 15 minutes aft…

This study looks at whether the urea-to-creatinine ratio in blood can track metabolic changes in patients with septic shock. Currently, doctors use a special machine (indirect calorimetry) to measure energy needs, but it's not always available. Researchers will compare the simple…

This study will enroll 100 adults with septic shock to compare two non-invasive methods for measuring how well the heart is pumping blood: standard ultrasound (echocardiogram) and a newer device called electrical cardiometry, which uses sensors on the chest. The goal is to see if…

This study will measure thyroid and adrenal hormone levels in 200 ICU patients with septic shock. The goal is to understand how these glands are affected during severe infection. No treatment is given; the study only observes and records hormone changes.

This study aims to find the best way to dose the antibiotic ceftazidime for patients in intensive care with serious infections. Many ICU patients don't get enough of the drug because their bodies process it differently. The researchers will test a personalized dosing plan to keep…

This observational study tests a new bedside device that measures nucleosome levels in the blood of critically ill ICU patients. Researchers want to see if these levels can predict which patients are likely to die within 30 days. The study will enroll 130 adults with conditions l…

Sepsis is a life-threatening reaction to infection, and choosing the right antibiotic quickly is critical. This study will analyze data from 10,000 adults treated for sepsis in an emergency department to build a predictive model that estimates the likelihood of multidrug-resistan…