Can early combo therapy shield kidneys in septic shock?

NCT ID NCT07418541

Not yet recruiting Disease control Sponsor: Universitas Sumatera Utara Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether giving intravenous fluids and a blood-pressure-raising drug (norepinephrine) together early can prevent acute kidney injury in adults with septic shock. Researchers will treat 100 patients in the ICU or emergency department and monitor kidney function and blood pressure changes. The goal is to see if this early combination approach reduces kidney damage compared to standard timing.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: norepinephrine (noradrenaline) and crystalloid fluids
What this could lead to: If successful, this could show that giving fluids and a blood-pressure drug together early helps prevent kidney damage in septic shock patients.
What could go wrong: This is a small, early-stage study (100 people) with no control group, so results may not be definitive. The approach is already standard care, so benefits may be modest.

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Conditions

The condition(s) this trial relates to.

Sepsis toxic shock syndrome acute kidney injury prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE KIDNEY INJURY SEPTIC SHOCK

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Other studies related to the condition(s) this trial covers.