Toxic shock syndrome

This study tests whether giving a personalized dose of Pentaglobin (an antibody treatment) after surgery helps people with severe abdominal infection (peritonitis) and sepsis recover better. Researchers will enroll 200 patients and track organ failure and survival. The goal is to…

This study tests whether reducing immunosuppressive drugs (along with giving a steroid) helps kidney transplant patients recover from septic shock or severe breathing failure in the ICU. About 212 adults whose transplant was at least 3 months ago will be randomly assigned to eith…

This pilot study tests whether adding fludrocortisone (a steroid pill) to standard hydrocortisone treatment helps people with septic shock. Only 32 critically ill adults will take part. The main goal is not to see if the combo works, but to check if a larger, more definitive tria…

This study tests whether a non-invasive ultrasound device, aimed at the spleen, can safely reduce dangerous inflammation in people with septic shock. Septic shock is a life-threatening condition where the body's response to infection causes organ damage. Forty adults in the inten…

This study tests whether giving the drug norepinephrine early and adjusting the dose quickly can improve survival in adults with septic shock. Researchers will compare this approach to standard care with a placebo. Six hundred participants will be monitored for 28 days to see if …

This study tests whether using early drug monitoring and a dose-adjustment calculator can help infants under 90 days old with sepsis reach target vancomycin levels more quickly. Currently, doctors must wait 24-48 hours to check drug levels, which can delay effective treatment. Th…

This study looks at whether a special blood filter called oXiris helps people with septic shock and kidney failure survive. Researchers will review medical records of 360 adults in the ICU who needed continuous blood filtering. They will compare those who got the oXiris filter wi…

This study compares two fluids—sodium lactate and a concentrated saline solution—in 40 adults with septic shock. The goal is to see which one better supports blood flow and acid balance. Participants will receive either fluid in a double-blind setup, and researchers will measure …

This pilot study tests whether a mild electrical pulse to the ear (vagus nerve stimulation) can reduce inflammation and improve heart rate balance in people with septic shock. 34 participants will be randomly assigned to receive either active stimulation or a sham (placebo) for 4…

This study is testing whether giving fewer non-essential fluids to adults with septic shock can improve outcomes. The trial will enroll 1,850 patients in intensive care, comparing a restrictive fluid strategy to usual care. The main goal is to see if this approach reduces deaths …

This study tests if a medicine called methylene blue can help improve blood flow in patients with septic shock, a severe infection that causes dangerously low blood pressure. About 50 adults will receive either methylene blue or standard care for 3 days. The main goal is to see i…

This study is testing whether a powerful antibiotic called piperacillin/tazobactam can be given as a continuous shot under the skin instead of through an IV line. About 240 adults with serious bacterial infections will be randomly assigned to receive the drug either subcutaneousl…

This study tests whether a heart-lung bypass machine (ECMO) can help children with severe septic shock survive. Researchers will enroll 60 children and track how many leave the hospital alive. They also want to find the best time to start ECMO and which factors affect success.

This study tests whether giving the drug vasopressin earlier or later during septic shock leads to better outcomes. Researchers will use a computer alert system to randomly assign 300 ICU patients to early or standard timing. The goal is to see if the timing can be reliably contr…

This pilot study tests whether giving angiotensin II early in the emergency department can help stabilize blood pressure in patients with septic shock. Twenty adults who need a standard drug called norepinephrine will receive angiotensin II as an add-on. The main goal is to see i…

This study tests whether giving two steroids—hydrocortisone and fludrocortisone—for up to 7 days can lower the risk of death in adults with septic shock. About 336 patients will be randomly assigned to receive either the steroid combo or standard care alone. The main goal is to s…

This early study tests whether draining lymph fluid from the chest can lower harmful inflammation in people with septic shock. Ten adults in the surgical ICU will have a tube placed in their thoracic duct to drain lymph for up to 7 days. The goal is to see if this procedure is sa…

This registry study is following 200 adults with sepsis or septic shock who receive ARTICE® therapy in the ICU. Researchers are tracking organ function, survival, and complications to see how well the treatment works in everyday practice. The goal is to identify which patients be…

This study compares two ways of giving the antibiotic cefepime to very sick patients with sepsis in the ICU. The new method adjusts the dose based on the patient's kidney function, using only standard doses. The main goal is to see if this approach is easy for doctors to use and …

This study tests whether giving vasopressin early, along with norepinephrine, is better than waiting to use it as a rescue treatment for people with septic shock. About 2,800 critically ill adults will be randomly assigned to one of two strategies. The main goal is to see which a…

This study looks at whether giving steroids very early to patients with severe infections and low blood pressure works better than waiting until standard treatments fail. About 230 adults will be randomly assigned to get either early steroids or a placebo, and neither they nor th…

This study looks at 240 adults with septic shock who develop a new, fast heart rhythm problem. It compares three treatment approaches: controlling heart rate with low-dose amiodarone, restoring normal rhythm with high-dose amiodarone or electric shock, or managing risk factors wi…

This study tests whether giving zinc supplements along with standard antibiotics can reduce deaths and improve recovery in young infants (0-59 days old) hospitalized with severe infections like sepsis or pneumonia. About 3,250 babies in Tanzania will receive either zinc or a plac…

This study compares adrenaline and dopamine to treat a severe type of septic shock in children that doesn't improve with fluids. The goal is to see which drug better improves vital signs like blood pressure, heart rate, and urine output. The trial will include 90 children aged 1 …

This study tests whether giving the steroid hydrocortisone to children with septic shock can prevent new or worsening organ failure. About 500 children in intensive care will receive either hydrocortisone or a placebo for up to seven days. The goal is to see if this treatment imp…

This study tests whether adding a second antibiotic (fosfomycin) to the standard antibiotic (ceftazidime) helps people with severe gram-negative infections recover faster. About 100 hospitalized adults will be randomly assigned to get either the combo or the standard drug plus a …

This study tests whether a combination of clinical guidelines, feedback, and education can reduce the overuse of vancomycin in children with suspected sepsis in intensive care units. Over 52,000 patients and many clinicians across five hospitals will take part. The goal is to low…

This study tests whether measuring a substance called IL-6 in the blood can quickly predict if an emergency room patient with a suspected infection will develop sepsis or septic shock. Researchers will enroll 450 adults admitted from the ER and track their outcomes for up to 30 d…

This study investigates whether a urine test called Nephrocheck can predict which patients with septic shock will develop severe acute kidney injury. The test measures two markers of kidney damage (TIMP2 and IGFBP7). Researchers will analyze data from previous studies involving a…

This early study is testing a radioactive tracer called [18F]F-TMP that is injected into the body and then tracked with a PET/CT scan. The goal is to see if the tracer collects at sites of bacterial infection, making them visible on the scan. Twenty adults with known or suspected…

This study is testing whether measuring a substance called IL-6 in the blood can help predict which patients with sepsis or septic shock are most likely to die within 28 days. Researchers will enroll 700 adults in intensive care units (ICUs) and follow them for 28 days. If the te…

This study looks at using a computer algorithm to quickly diagnose sepsis and septic shock from routine hospital data. Researchers will analyze information from 10,000 ICU patients to see if the algorithm can speed up diagnosis and improve patient outcomes. The goal is to help do…

This study tests whether using a device that measures blood flow to the skin (called the peripheral perfusion index) can help doctors give fluids more precisely to elderly ICU patients with sepsis or shock. The goal is to prevent acute skin failure, a serious condition where the …

This study compares two sedation methods for elderly ICU patients (65+) who need a breathing tube. One group gets a mix of propofol and ketamine, the other gets propofol alone. The goal is to see which causes fewer dangerous drops in blood pressure. The trial involves 41 particip…

This study tests whether giving antibiotics through a small, portable pump over 24 hours is safe and cost-effective for children with serious bacterial infections. About 150 kids who are stable enough for home care will receive the pump instead of multiple daily hospital injectio…

This study looks at how the immune system changes with age and how that affects the risk of infections in people 60 and older. Researchers will collect blood, urine, stool, and other samples from elderly patients with infections and healthy older adults. By analyzing immune cells…

This study looks at blood samples from 350 adults with blood cancer who develop a fever and have very low white blood cells (a condition called febrile neutropenia). The goal is to find patterns of proteins in the blood that can predict if a patient will develop serious complicat…

This study aims to improve how doctors evaluate and manage people who have been exposed to bioterrorism agents (like anthrax) or emerging infectious diseases (like SARS or new flu strains). Up to 200 participants, including patients and healthcare workers, will be monitored and t…

This study compares two methods for guiding early treatment in people with septic shock, a severe infection that can cause organ failure. The standard approach uses blood lactate levels, but this trial tests whether using the CO2 gap (a measure of blood flow) is better at reducin…

This study is testing a new rapid diagnostic device called In-Dx to quickly identify infections and antibiotic resistance in emergency patients with suspected sepsis. Researchers will compare the device's results to standard lab cultures using stored samples from 2,500 patients. …

This study looks at small molecules called miRNAs in the blood of patients with septic shock. The goal is to understand why some patients develop a weakened immune system after sepsis, which can lead to more infections and higher risk of death. Researchers will compare miRNA patt…

This study is observing 1,000 people with liver cirrhosis who have bacterial infections and are being treated with β-lactam antibiotics. Researchers want to see how the body processes these drugs and whether personalized dosing could improve survival. The study is observational, …

This study looks at whether a simple ultrasound measurement of how well the right side of the heart works with the lungs can predict which sepsis patients are at higher risk of dying in the hospital. Researchers will follow 215 adults with sepsis in the ICU, measuring this heart-…

This study is testing whether a continuous glucose monitor (CGM) designed for diabetes can work in intensive care patients with septic shock. Currently, nurses must prick patients' fingers every 2 hours to check blood sugar, which is painful and disruptive. The CGM uses a small s…

This study is measuring cortisol levels in 183 adults with sepsis or septic shock in the ICU to see if those levels can predict who is at higher risk of dying. Researchers will track deaths in the ICU and at 28 and 90 days. The goal is to help doctors identify high-risk patients …

This study looks at whether frailty—measured by a simple scale—can predict death in adults aged 18 to 65 admitted to intensive care for septic shock. Researchers will track 200 patients to see if those who are frail have a higher risk of dying within 28 days, even after accountin…

This study will check if a new scoring system called SOFA-2 can better predict which ICU patients are likely to die within 30 days, compared to the current standard. Researchers will also measure how common sepsis and septic shock are in Turkish intensive care units. About 2,500 …

This study aims to create a new scoring system (SOFA-OBS) that better predicts death risk for pregnant and postpartum women in intensive care. Researchers will collect routine data from 130 patients and test if a simple pulse oximeter can replace painful blood draws. The goal is …

This study looks at two different ultrasound techniques to help doctors decide how much fluid to give patients with septic shock. One method measures the heart's left ventricle, while the other checks blood flow in the carotid artery. The goal is to see which is more accurate at …

This study tests a new, lightweight ultrasound device called NeoDoppler that can be gently placed on a newborn's soft spot (fontanelle) to continuously measure blood flow in the brain. Researchers will enroll 180 preterm and full-term infants, including those with conditions like…

This study is looking at whether early signs of inflammation in the blood can help identify which patients with infections are at risk for serious complications like sepsis. Researchers will follow 4,200 adults with confirmed or suspected infections, as well as healthy controls, …

This study looks at how a blood-filtering cartridge (HA 380) used with continuous kidney dialysis removes antibiotics in ICU patients with septic shock and kidney failure. Researchers will take blood samples before and after the filter at several time points to measure changes in…

This study looks at how different menstrual products—tampons, cups, and pads—affect the bacteria and immune cells in the vagina. Researchers will collect samples from 300 women aged 18-49 to compare these groups. The goal is to understand if internal products like tampons and cup…

This study looks at whether a new blood gas ratio can help predict which patients with septic shock are more likely to survive. Researchers will measure this ratio and compare it to standard lactate levels in 30 adults with septic shock. The goal is to see if the ratio gives earl…

This early-stage study is testing whether a single dose of an experimental antibiotic combination (sulopenem etzadroxil plus probenecid) is safe and tolerable in 12 adolescents already receiving standard antibiotics for a bacterial infection. Researchers will measure how the drug…

This study is observing about 1,950 emergency patients with suspected sepsis to see if new blood tests (like calprotectin and bacterial DNA tests) can detect infections faster and more accurately than current methods. The goal is to find better ways to diagnose sepsis and tailor …

This study looks at how the antibiotic ceftazidime avibactam behaves in 30 children with severe infections who are in intensive care, some on life support. Researchers will measure drug levels in the blood to understand the right dose. The goal is to improve treatment for life-th…

This study looks at how the antifungal medicine caspofungin behaves in children with severe infections, especially those with liver problems or on life support like ECMO. Researchers will measure drug levels in the blood to understand dosing needs. About 60 children in intensive …

This study will collect data from 2,000 children admitted to pediatric intensive care units (PICUs) with severe infections across major Chinese cities. Over 10 years, researchers will track which germs cause these infections, how they are treated, and patient outcomes. The goal i…

This study looks at how well the Oxiris blood filter removes harmful toxins in adults with septic shock in the ICU. Researchers will take blood samples before and after the filter over 24 hours to see when it stops working. No new treatment is given—just observation. The goal is …

This study looks at two common antibiotic combinations given to hospitalized adults with infections: vancomycin plus piperacillin-tazobactam, or vancomycin plus cefepime. The goal is to see if one is less likely to cause kidney injury than the other, using more sensitive markers …

This study looks at 60 people with septic shock, a severe infection that causes dangerously low blood pressure. Doctors need to give fluids carefully, but too much can be harmful. The trial compares two methods—a heart monitor (cardiometry) and an ultrasound of a large vein (IVC …

This study aims to find epigenetic markers in the blood that could predict whether a patient with sepsis will develop the more dangerous septic shock. Researchers will take blood samples from 25 male patients after major digestive cancer surgery who develop sepsis. By comparing m…

This observational study looks at whether certain genetic elements, called transposable elements, can prematurely age the immune system in people with sepsis. Researchers will analyze blood samples from 116 ICU patients with sepsis to see if these elements are linked to higher de…

This study looks at a severe condition called mixed cardiogenic-vasoplegic shock, where the heart fails to pump and blood vessels widen too much. Researchers will review medical records from 2,500 patients in three French hospitals to understand who gets this condition and how th…

This study looks at how well two different software programs measure heart function in people with septic shock, a life-threatening infection that affects the whole body. Researchers will use existing heart ultrasound data from 60 adults to see if the measurements agree and can b…

This study is looking at whether a protein called vasorin (Vasn) in the blood can help doctors quickly tell the difference between septic shock (caused by infection) and other types of shock (like after heart surgery). Currently, the best test for this is not always accurate. The…

This study looks at the best way to stop the blood pressure medication vasopressin in people with septic shock. It compares slowly reducing the dose versus stopping it all at once. The goal is to see which method causes fewer dangerous drops in blood pressure. The study involves …

This study collects information from about 100 adults in Alsace who have had a confirmed case of human anaplasmosis, a bacterial infection spread by ticks. Researchers want to learn more about how common it is, what symptoms people have, and how serious it can be. The goal is to …

This study watches how doctors use vasopressin, a second blood pressure drug, in adults with septic shock in the ICU. It aims to see if starting it earlier lowers death rates and helps protect kidney function. Researchers will track 1,200 patients to gather real-world data.

This study compares two ways to manage fluids in cirrhosis patients with severe sepsis or septic shock. One method uses a bedside heart ultrasound (POCUS) to guide fluid amounts, while the other follows standard sepsis guidelines. The goal is to see if ultrasound-guided care redu…

This study looks at whether adding certain nutrients to blood cells from people with septic shock can help restore the cells' energy-making machinery (mitochondria). Researchers will collect blood samples from 55 patients in the ICU and test these nutrients in the lab. The goal i…

This observational study is watching how the body's metabolism changes when septic shock patients receive a rapid fluid infusion. Researchers will measure oxygen use and other markers before and after the fluid challenge in 120 adults. The goal is to find patterns that could guid…

This pilot study is testing whether a smart wristband can accurately measure drug levels in sweat compared to standard blood tests. Researchers will collect sweat, saliva, and blood samples from 100 patients with chronic or infectious diseases who are taking medications like cycl…

This study is observing 1,000 critically ill ICU patients to learn how their bodies respond to life-threatening infections and injuries. Researchers will collect blood and lung fluid samples to identify biological factors that could lead to earlier diagnosis and new treatments fo…

This study is looking for new ways to diagnose sepsis, a life-threatening reaction to infection, earlier in the emergency room. Researchers will study the immune responses of 3,300 adults with suspected infections to find patterns that signal sepsis. The goal is to improve diagno…

This registry is tracking 3,000 critically ill patients who receive the CytoSorb blood-filtering device in real-world intensive care settings. The goal is to collect data on how the device is used and whether it relates to patient survival. It covers many conditions like sepsis, …