Could a second steroid boost survival in septic shock? tiny trial paves way

NCT ID NCT07451886

Recruiting now Disease control Sponsor: Chinese University of Hong Kong Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This pilot study tests whether adding fludrocortisone (a steroid pill) to standard hydrocortisone treatment helps people with septic shock. Only 32 critically ill adults will take part. The main goal is not to see if the combo works, but to check if a larger, more definitive trial is possible.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Fludrocortisone (a steroid hormone) given as a pill, plus standard hydrocortisone (another steroid) given intravenously
What this could lead to: If this pilot shows the larger trial is feasible, it could lead to a definitive study that may prove adding fludrocortisone saves more lives from septic shock.
What could go wrong: This is a very small pilot (32 patients) testing only whether a larger trial can be done, not whether the drug works. Even if the larger trial happens, the combination may not reduce deaths.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

infectious disease with sepsis Sepsis toxic shock syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SEPSIS SEPSIS - TO REDUCE MORTALITY IN THE INTENSIVE CARE UNIT SEPSIS AND SEPTIC SHOCK SEPSIS AT INTENSIVE CARE UNIT SEPTIC SHOCK

Contacts and locations

Locations

North District Hospital
NOT_YET_RECRUITING

Hong Kong, Hong Kong
Pamela Youde Nethersole Hospital
NOT_YET_RECRUITING

Hong Kong, Hong Kong
Prince of Wales Hospital
RECRUITING

Hong Kong, Hong Kong
Princess Margaret Hospital
NOT_YET_RECRUITING

Hong Kong, Hong Kong
Queen Mary Hospital
NOT_YET_RECRUITING

Hong Kong, Hong Kong

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