Could cutting back on IV fluids save lives in septic shock?
NCT ID NCT06140147
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study is testing whether giving fewer non-essential fluids to adults with septic shock can improve outcomes. The trial will enroll 1,850 patients in intensive care, comparing a restrictive fluid strategy to usual care. The main goal is to see if this approach reduces deaths and serious complications.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- protocolized reduction of non-resuscitation fluids (intravenous fluids, enteral water, nutrition, and glucose)
- What this could lead to
- If successful, this could establish a safer fluid management strategy for septic shock, potentially reducing deaths and complications in intensive care.
- What could go wrong
- This is a large but early-stage trial without a defined phase. The intervention is a change in clinical practice, not a new drug, so benefits may be modest. There is a risk of dehydration or electrolyte imbalances if fluids are overly restricted.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Danderyd Hospital
RECRUITINGDanderyd, Sweden
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Falun Hospital
RECRUITINGFalun, Sweden
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Halmstad Hospital
RECRUITINGHalmstad, Sweden
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Helsingborg Hospital
RECRUITINGHelsingborg, Sweden
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Helsinki University Hospital
RECRUITINGHelsinki, Finland
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Kuopio University Hospital
NOT_YET_RECRUITINGKuopio, Finland
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Malar Hospital
RECRUITINGEskilstuna, Sweden
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Norrtälje Hospital
RECRUITINGNorrtälje, Sweden
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Sahlgrenska University Hospital
RECRUITINGGothenburg, Sweden
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Skåne University Hospital, Lund
RECRUITINGLund, Sweden
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Skåne University Hospital, Malmö
RECRUITINGMalmö, Sweden
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Stockholm South General Hospital (SÖS)
RECRUITINGStockholm, Sweden
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Södertälje Hospital
NOT_YET_RECRUITINGSödertälje, Sweden
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Tampere University Hospital
NOT_YET_RECRUITINGTampere, Finland
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Turku University Hospital
NOT_YET_RECRUITINGTurku, Finland
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University Hospital of Umeå
RECRUITINGUmeå, Sweden
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University Hospital of Wales
NOT_YET_RECRUITINGCardiff, United Kingdom
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Uppsala University Hospital
RECRUITINGUppsala, Sweden
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Varberg Hospital
RECRUITINGVarberg, Sweden
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Örebro University Hospital
RECRUITINGÖrebro, Sweden
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Östersund Hospital
RECRUITINGÖstersund, Sweden
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Östra Hospital
RECRUITINGGothenburg, Sweden
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Other studies related to the condition(s) this trial covers.
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