Can tracking immune chaos in sepsis reveal new treatment targets?

NCT ID NCT07735741

Not yet recruiting Knowledge-focused Sponsor: National Heart, Lung, and Blood Institute (NHLBI) Source: ClinicalTrials.gov ↗

First seen Jul 30, 2026 · Last updated Jul 31, 2026 · Updated 1 time

Summary

Sepsis happens when the body's immune response spirals out of control, damaging organs and causing about 1 in 5 deaths worldwide. This study follows 500 adults hospitalized with sepsis to track how their immune systems change over time. Researchers will collect blood samples and medical data to understand the role of specific immune cells, with the goal of identifying new ways to treat sepsis.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If this study clarifies how the immune system goes awry in sepsis, it could point toward new treatments that calm the immune response and reduce organ damage.
What could go wrong: This is an observational study, not a treatment trial, so it will not directly test any therapy. The findings may not lead to immediate clinical changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

infectious disease with sepsis Sepsis toxic shock syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SEPSIS SEPSIS-ASSOCIATED IMMUNE DYSREGULATION SEPTIC SHOCK

Contacts and locations

Locations

INOVA Fairfax Hospital

Falls Church, Virginia, 22042, United States

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