Could sepsis prematurely age your immune system?

NCT ID NCT06809868

Recruiting now Knowledge-focused Sponsor: University of California, San Francisco Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This observational study looks at whether certain genetic elements, called transposable elements, can prematurely age the immune system in people with sepsis. Researchers will analyze blood samples from 116 ICU patients with sepsis to see if these elements are linked to higher death rates or more secondary infections. Participants only provide blood samples and receive no experimental treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could reveal new biological markers that help predict which sepsis patients are at higher risk of complications, pointing toward future treatments.
What could go wrong: This is an observational study, not a treatment trial, so it won't directly test any therapy. The findings may not lead to immediate clinical changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

coinfection infectious disease with sepsis multiple organ dysfunction syndrome Sepsis toxic shock syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SEPSIS SEPSIS AND SEPTIC SHOCK SEPSIS AT INTENSIVE CARE UNIT SEPSIS SEVERE SEPSIS WITH ACUTE ORGAN DYSFUNCTION SEPSIS WITH MULTIPLE ORGAN DYSFUNCTION (MOD) SEPSIS, SEPTIC SHOCK SEPSIS, SEVERE SEPSIS AND SEPTIC SHOCK

Contacts and locations

Locations

University of California, San Francisco
RECRUITING

San Francisco, California, 94143, United States

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