SEPSIS, SEVERE

This study tests whether giving steroids very early to patients with severe infection and low blood pressure improves survival compared to waiting until standard treatments fail. About 230 adults will receive either early steroids or a placebo, with both patients and doctors unaw…

This study looks at whether giving gamma globulin (a blood product with antibodies) can help children in the ICU who have severe infections and a dangerous overreaction called an inflammatory storm. The goal is to see if it lowers the risk of death and shortens time in the ICU. R…

This study observes about 1,950 patients with suspected sepsis in the emergency department. Researchers will analyze blood samples to see how well certain markers (like calprotectin) and rapid DNA tests can detect infections. The goal is to better understand sepsis and move towar…

This study looks at whether certain genetic elements, called transposable elements, can prematurely age the immune system of people with sepsis in the ICU. Researchers will take blood samples from 116 adult patients to see if these elements are linked to higher death rates or mor…

This study is testing whether a brain activity monitor (called BIS) can help doctors quickly tell how severe sepsis is in critically ill patients. Researchers will compare BIS readings with a standard blood test (procalcitonin) in 20 patients with sepsis. The goal is to see if BI…

This study is looking for new ways to quickly diagnose sepsis, a life-threatening reaction to infection, in the emergency room. Researchers will study the immune responses of 3,300 adults with suspected infections to find patterns that signal sepsis. The goal is to improve early …

This study aims to see if a program that includes guidelines, feedback, and education can reduce the use of vancomycin (a strong antibiotic) in children with suspected sepsis in intensive care units. About 52,500 children will be involved across five hospitals. The goal is to low…