New strategy could slash antibiotic overuse in sick kids
NCT ID NCT05975671
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tests whether a combination of clinical guidelines, feedback, and education can reduce the overuse of vancomycin in children with suspected sepsis in intensive care units. Over 52,000 patients and many clinicians across five hospitals will take part. The goal is to lower side effects like kidney damage and fight antibiotic resistance.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
behavioral intervention (clinical guidelines, feedback, and education)
What this could lead to
If successful, this could provide a proven way to reduce antibiotic overuse in pediatric ICUs, lowering the risk of kidney damage and antibiotic resistance.
What could go wrong
This is an early-stage behavioral study, not a drug trial. Results may vary across hospitals, and the intervention might not change prescribing habits as hoped.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Children's Healthcare of Atlanta
RECRUITINGAtlanta, Georgia, 30322, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Children's Hospital of Philadelphia
RECRUITINGPhiladelphia, Pennsylvania, 19146, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Johns Hopkins Children's Center
RECRUITINGBaltimore, Maryland, 21287, United States
Contact Email: •••••@•••••
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St. Louis Children's Hospital
RECRUITINGSt Louis, Missouri, 63110, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••