New strategy could slash antibiotic overuse in sick kids

NCT ID NCT05975671

Recruiting now Disease control Sponsor: Children's Hospital of Philadelphia Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tests whether a combination of clinical guidelines, feedback, and education can reduce the overuse of vancomycin in children with suspected sepsis in intensive care units. Over 52,000 patients and many clinicians across five hospitals will take part. The goal is to lower side effects like kidney damage and fight antibiotic resistance.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: behavioral intervention (clinical guidelines, feedback, and education)
What this could lead to: If successful, this could provide a proven way to reduce antibiotic overuse in pediatric ICUs, lowering the risk of kidney damage and antibiotic resistance.
What could go wrong: This is an early-stage behavioral study, not a drug trial. Results may vary across hospitals, and the intervention might not change prescribing habits as hoped.

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Conditions

The condition(s) this trial relates to.

bacterial infectious disease with sepsis infectious disease with sepsis interstitial nephritis Sepsis Toxemia toxic shock syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANTIMICROBIAL - INDUCED NEPHROPATHY SEPSIS SEPSIS BACTEREMIA SEPSIS MRSA SEPSIS SEVERE SEPTIC SHOCK SEPTIC SYNDROME

Contacts and locations

Locations

Children's Healthcare of Atlanta
RECRUITING

Atlanta, Georgia, 30322, United States
Children's Hospital of Philadelphia
RECRUITING

Philadelphia, Pennsylvania, 19146, United States
Johns Hopkins Children's Center
RECRUITING

Baltimore, Maryland, 21287, United States
St. Louis Children's Hospital
RECRUITING

St Louis, Missouri, 63110, United States

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