ICU study checks if blood filters zap Life-Saving antibiotics

NCT ID NCT07230041

Recruiting now Knowledge-focused Sponsor: Niguarda Hospital Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at how a blood-filtering cartridge (HA 380) used with continuous kidney dialysis removes antibiotics in ICU patients with septic shock and kidney failure. Researchers will take blood samples before and after the filter at several time points to measure changes in antibiotic levels. The goal is to understand drug loss so doctors can better dose antibiotics in these critically ill patients.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: hemoadsorption cartridge (HA 380) and continuous renal replacement therapy
What this could lead to: If successful, this study could help doctors adjust antibiotic doses more accurately for ICU patients on blood purification, improving treatment effectiveness.
What could go wrong: This is a very small, early observational study with only 20 participants. It measures drug levels but does not test any new treatment or patient outcomes.

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Conditions

The condition(s) this trial relates to.

acute kidney injury toxic shock syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SEPTIC SHOCK

Contacts and locations

Locations

Niguarda Hospital
RECRUITING

Milan, Italia, 20162, Italy

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