Niguarda Hospital

This study tests whether colchicine, a common anti-inflammatory drug, can help people with chronic heart muscle inflammation (inflammatory cardiomyopathy). About 80 adults with this condition will receive either colchicine or a placebo to see if it prevents worsening heart failur…

This study is testing a device called EmboTrap II, which is used to remove blood clots from the brain in people having a stroke. The goal is to see if it is safe and works well at restoring blood flow. About 100 participants will be followed to track outcomes like bleeding and su…

This study tracks 180 people who had a serious but stable pulmonary embolism (a blood clot in the lung) and received a treatment that uses ultrasound waves to help a clot-busting drug work better. The main goal is to see if this approach reduces the chance of developing pulmonary…

This study looks at whether a special ultrasound (CEUS) can find hidden bleeding pockets (pseudoaneurysms) in the liver, spleen, or kidneys after an injury, just as well as the standard CT scan. About 385 adults with abdominal trauma will be followed over time with both tests. If…

This study is testing whether a blood test, called a liquid biopsy, can accurately diagnose and monitor heart masses (tumors) without needing a surgical biopsy. Researchers will collect blood samples from 26 patients aged 12 and older with suspected or confirmed cardiac masses. T…

This study compares two ways to help pneumonia patients who have trouble breathing: alternating between a mask that helps push air in (non-invasive ventilation) and high-flow oxygen through the nose, versus using high-flow oxygen alone. The goal is to see which approach improves …

This study compares two ways to position patients during robot-assisted surgery to remove small kidney tumors. One group lies on their side (standard flank position), while the other lies on their back (supine position). The goal is to see which position leads to fewer complicati…

This study is a registry that will follow 3000 people hospitalized with cardiogenic shock, a life-threatening condition where the heart suddenly cannot pump enough blood. Researchers will collect information on how patients are treated and what happens to them over time. The goal…

This observational study looks at whether a liquid biopsy (ctDNA test) can help select metastatic colorectal cancer patients who might benefit from retreatment with anti-EGFR drugs. Researchers will collect data from 250 patients already screened in a prior trial. The goal is to …

This study looks back at medical records of 5,000 adults who had blunt trauma to the chest or belly area. Researchers want to learn how often the adrenal gland is injured and how that affects recovery. The goal is to better understand this rare injury, not to test a new treatment…

This study watches over 1000 adults having laparoscopic appendix removal to see if washing the belly with fluid (lavage) reduces the chance of internal infections. Doctors will note how dirty the belly is and decide on washing based on a new classification system. The goal is to …

This study looks at how a blood-filtering cartridge (HA 380) used with continuous kidney dialysis removes antibiotics in ICU patients with septic shock and kidney failure. Researchers will take blood samples before and after the filter at several time points to measure changes in…

This study looks at people getting a new heart valve (TAVR) for a narrowed aortic valve. It compares two ways of placing the valve: one carefully aligned and one random. The goal is to see if the random method still allows doctors to easily reach the heart arteries later if neede…

This study looks at whether using a dye called indocyanine green (ICG) during surgery for advanced stomach cancer helps surgeons see cancer more clearly and change their approach. About 360 adults with stomach cancer will take part. The goal is to see if the dye improves how surg…

This study looks at how aging inside our cells might make heart arteries more prone to dangerous plaques. Researchers will measure DNA damage and other aging markers in 300 adults with different types of chest pain or heart attacks. The goal is to find better ways to predict who …

This study follows 2500 people who had a TAVR procedure to replace a narrowed heart valve. Researchers will track bleeding and clotting events over time to see how different blood-thinner medicines affect risk. The goal is to find the best treatment plan for each patient based on…

This study looks at 26 people with severe heart failure who are in cardiogenic shock, a life-threatening condition where the heart can't pump enough blood. Researchers will measure specific markers in the blood related to inflammation and blood vessel health. The goal is to bette…

This study looks at how the bacteria in your gut might affect epilepsy that doesn't get better with standard medicines. Researchers will follow 120 people aged 3 to 50 who have drug-resistant epilepsy and are starting a new treatment like surgery or a special diet. The goal is to…

This study looks at how liver cancer avoids being attacked by the immune system. Researchers will analyze tumor tissue and blood from 270 people with liver cancer to find specific molecules that help cancer hide. The goal is to better understand these escape mechanisms, which cou…

This observational study is testing whether advanced heart imaging (MRI or CT scans) can find blood clots in the heart that standard ultrasound might miss. It involves 125 people who had a stroke of unknown cause and have mild heart disease. The goal is to better understand strok…