Niguarda Hospital

This study tests whether colchicine, a drug used for gout, can help people with chronic heart muscle inflammation (inflammatory cardiomyopathy). About 80 adults with this condition will receive colchicine or a placebo for 6 months. The goal is to see if the drug reduces heart fai…

This study looks at how safe and effective the EmboTrap II device is at removing blood clots in people having a severe stroke. About 100 participants will be watched to see if the device can restore blood flow to the brain without causing harm. The goal is to improve recovery by …

This study is testing whether a new surgical position is better than the standard one for patients having robotic surgery to remove a small kidney tumor. Researchers want to see if having patients lie on their back, instead of on their side, leads to fewer complications, less pai…

This study explores whether a blood test (liquid biopsy) can accurately diagnose heart masses, distinguishing benign from malignant tumors without invasive tissue sampling. Researchers will collect blood from 26 participants aged 12 and older with known or suspected cardiac masse…

This study compares contrast-enhanced ultrasound (CEUS) with standard CT scans to detect pseudoaneurysms (bulging blood vessel walls) in the spleen, liver, or kidneys after abdominal trauma. Researchers will enroll 385 adults with blunt or penetrating injuries to see if CEUS can …

This study compares two breathing support methods for adults with pneumonia and low oxygen levels: alternating between a mask that helps breathing (NIV) and high-flow oxygen through the nose (HFO) versus using high-flow oxygen alone. The goal is to see which approach improves oxy…

This study looks at whether placing a new heart valve without special alignment makes it easier for doctors to re-enter the coronary arteries later. About 100 people with severe aortic stenosis getting a TAVR will be randomly assigned to standard or aligned valve placement. The m…

This study looks at how the bacteria in your gut might affect epilepsy that doesn't get better with standard medicines. Researchers will follow 120 people aged 3 to 50 who have drug-resistant epilepsy and are starting a new treatment like surgery or a special diet. By tracking ch…

This study looks at how aging cells in blood vessels contribute to heart disease. Researchers will measure DNA damage and other markers in 300 people with different types of chest pain or early heart disease. The goal is to understand why some plaques become unstable and cause he…

This study watches over 1000 adults having laparoscopic appendix removal to see if washing the belly with fluid (lavage) lowers the chance of internal infections. Doctors will classify how dirty the belly is during surgery and compare infection rates. The goal is to find out if w…

This study reviews medical records from 5000 adults who had blunt chest or belly trauma to learn how often adrenal gland injury occurs and how it affects recovery. Researchers want to clarify conflicting reports about short-term outcomes. No new treatments are tested; the goal is…

This study looks at how much antibiotic is removed when ICU patients with septic shock and kidney failure receive blood-cleaning treatments. Twenty adults will have their antibiotic levels checked before and after the blood passes through the cleaning cartridges. The goal is to h…

This study looks at how the body reacts during severe heart failure complicated by cardiogenic shock, a life-threatening condition where the heart can't pump enough blood. Researchers will measure markers of inflammation and blood vessel health in 26 adults to better understand t…

This study looks at people who had a stroke with no clear cause (called ESUS) and also have mild to moderate heart disease. The goal is to see if advanced heart scans like MRI or CT can find blood clots in the heart that standard ultrasound might miss. Finding these clots could h…

This study is testing whether a dye called indocyanine green, which glows under a special camera, can help surgeons see and remove more lymph nodes during stomach cancer surgery. About 360 adults with advanced stomach cancer will take part. The goal is to see if using this dye ch…

This study looks at how liver cancer cells avoid being attacked by the immune system. Researchers will analyze tumor samples from 270 patients to find specific genetic signals that cause immune cells to stop working. The goal is to better understand these mechanisms, which could …

This study is a registry that will collect information from 3000 people hospitalized with cardiogenic shock, a life-threatening condition where the heart suddenly can't pump enough blood. Researchers will track patients' medical profiles, treatments, and outcomes to better unders…

This study will follow 2500 people who had a TAVR procedure (a less invasive way to replace a heart valve) to better understand their risks of bleeding or blood clots afterward. Researchers will track different blood thinner treatments and types of replacement valves to see how t…

This study looks at whether a simple blood test (ctDNA) can help doctors decide if it's safe and effective to retreat patients with metastatic colorectal cancer using a targeted therapy called anti-EGFR. Researchers will collect and analyze data from 250 patients who have already…

This study looks at how well a treatment called ultrasound-assisted catheter-directed thrombolysis works for people with serious blood clots in the lungs (intermediate-high-risk pulmonary embolism). Researchers will track 180 participants for 6 months to see how many develop high…