Toxic shock syndrome

This study looks at giving the steroid hydrocortisone early to children (ages 2 months to 12 years) with septic shock. The goal is to see if it lowers the chance of death within 28 days and shortens time on blood pressure medicines and in the ICU. About 122 children will take par…

This study tested whether metformin, a common diabetes drug, is safe and practical to use for treating acute kidney injury caused by sepsis. Researchers gave low-dose metformin to 80 ICU patients with sepsis and kidney injury, monitoring for side effects and feasibility. The goal…

This study tested whether giving a single high dose of vitamin B12 (5 grams) to 20 adults with septic shock is feasible and safe. Patients received either vitamin B12 or a placebo (saline) alongside standard care. The main goal was to see if the study procedures could be complete…

This study tested a drug called GM-CSF in 166 ICU patients who had severe sepsis or septic shock and a weakened immune system. The goal was to see if the drug could reduce the number of new infections acquired in the ICU. Patients received either GM-CSF or a placebo, and research…

This study tested whether giving very high doses of vitamin C to people with sepsis (a severe infection that can cause organ failure) could reduce the risk of death within 28 days. 234 adults in the ICU received either vitamin C or a placebo for up to 4 days. The main goal was to…

This study looked back at 400 critically ill patients with septic shock and kidney failure who needed dialysis. Researchers compared those who received a special filter (Oxiris) that removes toxins and inflammation-causing substances to those who got standard filters. The goal wa…

This study tested a structured plan to remove excess fluid early in patients with septic shock. 170 ICU patients were randomly assigned to either the fluid removal protocol or standard care. The goal was to see if the plan could safely reduce fluid buildup by day three, which mig…

This study tested whether paramedics can improve survival by giving antibiotics and fluids to sepsis patients before reaching the hospital. Over 2,000 adults with suspected sepsis and low blood pressure were enrolled. The goal was to see if early treatment in the field reduces de…

This study tested whether giving three blood-pressure-raising drugs (norepinephrine, angiotensin II, and vasopressin) together early in septic shock works better than the usual stepwise approach. Researchers enrolled 79 adults with severe sepsis and low blood pressure despite flu…

This pilot study tested whether adding methylene blue to standard care is feasible for adults with septic shock in the intensive care unit. The main goal was to see if a larger trial could be done, not to prove the treatment works. Fifty patients took part, and the study looked a…

This study tests whether a special donor plasma product called OctaplasLG can help people with septic shock who develop blood clotting problems. Sixty participants will receive either OctaplasLG or a placebo (salt water) to see if the treatment improves clotting and outcomes. The…

This large study tested whether a 'balanced' fluid (Lactated Ringer) is better than normal saline for children with septic shock. Over 9,000 kids participated across multiple hospitals. The goal was to see which fluid reduces the risk of serious kidney problems or death within 30…

This large trial tested whether a lower-chloride fluid (Ringer's Lactate) reduces death and kidney injury compared to standard saline in 1,113 adults with septic shock. Participants received either fluid within 6 hours of hospital arrival. The study aims to settle a long-standing…

This study looked at whether reducing the use of strong, broad-spectrum antibiotics in cancer patients with sepsis or septic shock is as safe as continuing them. The goal is to lower the risk of creating drug-resistant bacteria. Researchers compared a de-escalation strategy to st…

This study tested whether methylene blue, a dye used in medicine, can help adults with septic shock recover faster. 88 participants received either methylene blue or a placebo for up to 5 days. The main goal was to see how quickly blood pressure stabilized without other drugs.

This study tested whether using ultrasound to guide fluid management could improve outcomes in 118 sepsis patients in the ICU. Doctors used ultrasound to check blood flow and heart function before deciding how much fluid to give. The goal was to see if this approach could lower d…

This pilot study tested whether giving a sodium lactate solution to people with septic shock could help manage their fluid balance. Septic shock is a life-threatening condition where blood pressure drops dangerously due to infection. The study involved 59 participants and compare…

This study tested whether a computer program called BestDose could help doctors give the right amount of the antibiotic amikacin to patients with septic shock. The goal was to get drug levels in the ideal range after the second dose. 180 patients took part, and researchers checke…

This study tested whether giving strong, early treatment to people with severe sepsis or septic shock right in the ambulance could lower the number of deaths. The treatment included early antibiotics and fluids to support blood pressure. The study involved 398 adults and measured…

This study tested whether a non-invasive arm cuff procedure, called remote ischemic conditioning, could reduce organ failure in 180 adults with septic shock. The cuff was inflated and deflated in cycles to mimic brief blood flow restriction. The goal was to see if this could prot…

This study looked at whether giving hospital-level care to acutely ill adults in their own homes in rural areas works well. 160 people with various conditions like infections, heart failure, or COPD took part. The goal was to see if this approach could lower costs and help patien…

This pilot study tested the safety of a blood-filtering procedure called therapeutic plasma exchange in 17 adults with septic shock, a life-threatening infection that causes organ failure. The procedure removes the liquid part of the blood and replaces it with fluids or donor pla…

This study tested a personalized approach to fluid management in 535 adults with septic shock. Doctors used a 'mini-fluid challenge'—a small amount of albumin given quickly—to check if more fluids would help, aiming to avoid fluid overload. The goal was to see if this tailored me…

This study tested whether giving intravenous immunoglobulin (IVIG) to children with toxic shock syndrome is practical and might help. Toxic shock is a rare but life-threatening reaction to bacterial toxins. The trial enrolled 30 children in intensive care, giving them either IVIG…

This study tested whether a urine test measuring two proteins (TIMP2 and IGFBP7) can tell which septic shock patients will recover normal kidney function within 72 hours. Researchers analyzed data from 77 patients in French ICUs. The goal is to help doctors decide who needs aggre…

This study looked at how well a new, quick finger-prick test (LumiraDx CRP) measures CRP levels compared to a standard lab test. CRP is a marker of infection, inflammation, or tissue injury. 79 adults with symptoms of these conditions took part. The goal was to see if the new tes…

This early study tested whether a special PET scan using a radioactive form of vitamin B9 (11C-PABA) can help doctors see infections deep inside the body. Researchers scanned 13 healthy people and patients with known or suspected infections. The goal was to see if this method can…

This study tested whether a whole-body compression bandage could help reduce fluid buildup in ICU patients with severe sepsis or septic shock. 64 patients on mechanical ventilation received the bandage within 12 hours of admission. Researchers tracked daily fluid balance and chec…

This pilot study tested whether manual lymphatic drainage, a gentle massage technique, is safe and feasible for patients recovering from septic shock. Researchers enrolled 24 adults in the ICU and compared those who received the massage plus usual care to those who received usual…

This study tested whether a probiotic called Bifidobacterium breve PRL2020 could reduce stomach issues like diarrhea in 121 children aged 3-12 who were taking amoxicillin antibiotics. The children took the probiotic alongside their antibiotic treatment. The goal was to see if it …

This completed pilot study tested whether two biomarkers (renin and DPP3) can predict how well patients with septic shock respond to angiotensin II, a drug that raises blood pressure. Forty adults with persistent low blood pressure despite standard treatment were randomly assigne…

This study looked at 335 adults hospitalized with bacterial infections to see if taking NSAIDs (like ibuprofen) before admission made their infections more severe. Researchers compared those with complicated infections (abscesses, needing surgery) to those with simpler infections…

This study tested whether simpler ultrasound measurements can accurately predict left ventricular function in patients with septic shock. Researchers enrolled 80 patients and compared standard heart function tests (LVEF and GLS) with easier-to-collect parameters like mitral annul…

This study looked at 526 adults with sepsis who had normal blood pressure to see if a simple measure called the diastolic shock index (DSI) and a blood test for lactate could predict which patients would need medication to support their blood pressure within 6 hours. Researchers …

This study tested whether a specific ultrasound-based algorithm could help doctors better manage fluids in patients with septic shock. The trial involved 136 intensive care patients and compared the algorithm to standard care over the first 4 days. The goal was to see if the algo…

This study looked at whether measuring hepcidin, a hormone that controls iron levels, in the blood of 114 patients with severe sepsis or septic shock could predict who would die within 28 days. Researchers also tracked deaths at 90 days and infections acquired in the hospital. Th…

This study looked back at medical records of 2,740 adults with type 2 diabetes who were admitted to the ICU for septic shock, a life-threatening infection. Researchers wanted to see if those who were already taking metformin (a standard diabetes pill) before getting sick had a lo…

This study looked at 60 intensive care patients with septic shock to see if their intestines become leaky, allowing bacteria to enter the blood. Researchers measured specific markers in the blood over a week to track gut damage and changes in gut bacteria. The goal was to better …

This study looked at 124 people with septic shock to see if the difference in carbon dioxide levels between veins and arteries could predict their recovery. Researchers monitored patients closely for three days and tracked organ failure and survival at 28 days. The goal was to fi…

This study looked at whether using a portable ultrasound machine at the patient's bedside (called POCUS) helps doctors better treat people with septic shock in the intensive care unit. Researchers compared two groups of patients: one treated before POCUS was widely used and one a…

This study aimed to find the best dose of the antibiotic ceftazidime for critically ill children with severe burns. Researchers took blood samples from 3 children to measure how the drug moves through the body. The goal was to learn how to personalize dosing to improve treatment …

This completed study looked at 945 patients with septic shock to compare two ways of dosing vasopressors (medicines that raise blood pressure): one based on the patient's weight, and one not. The goal was to see which approach leads to better outcomes and fewer side effects, espe…

This study looked at 440 ICU patients with septic shock to see how their heart's pumping and relaxation abilities affected survival. Researchers measured heart function using ultrasound and tracked fluid balance. The goal was to better understand which heart problems are linked t…

This early-phase study tested a single dose of the antibiotic omadacycline (Nuzyra) in 23 children aged 8 to 17 who were hospitalized with bacterial infections. Researchers measured how the drug moved through the body and checked for side effects. The goal was to gather safety an…

This study looked at 80 adults with septic shock to see if raising blood pressure from 65 mmHg to 85 mmHg improves kidney function. Researchers used ultrasound to measure kidney blood flow and tracked changes in kidney injury stages. The goal was to find out if a higher blood pre…

This study looked at whether measuring immature platelets in the blood can help predict how septic shock patients will fare. Researchers followed 196 intensive care patients and checked if the immature platelet fraction at admission was linked to death or organ failure at 28 days…

This study looked at whether giving a concentrated protein fluid called albumin, along with standard fluids, is possible in patients with septic shock (a life-threatening infection causing very low blood pressure). 47 adults took part to see if doctors could recruit enough patien…

This study looked at two blood markers—nCD64 and mHLA-DR—in 76 adults with septic shock, a life-threatening infection that can cause organ failure. Doctors measured these markers on day 1 and day 8 to see how the immune system changed over time. The goal was to learn whether thes…

This study looked at 103 adults with septic shock to see if a protein called VEGF-A is linked to how much extra fluid their bodies hold. Septic shock causes blood vessels to leak, leading to dangerous fluid buildup. Researchers measured VEGF-A levels and fluid balance to better u…

This study observed how fluids are given to nearly 5,000 critically ill patients in intensive care units (ICUs) worldwide. The goal was to describe current practices for fluid challenges (boluses) and maintenance fluids, and to see if different approaches are linked to patient ou…

This completed study looked at 52 adults with septic shock to see if a protein called PTP1B and gut barrier changes are linked to muscle loss. Researchers took blood samples and used ultrasound to measure muscle. The goal was to gather knowledge, not to test a treatment.

This study examined over 1,200 adults admitted to an intensive care unit to see if the reason they were admitted (like sepsis or breathing failure) could predict their risk of dying in the ICU, beyond what standard severity scores show. Researchers looked back at medical records …

This study tested a new imaging technique using a radioactive tracer called 11C-trimethoprim to see how it spreads in the bodies of 16 adults with suspected bacterial infections. Participants had PET/CT scans to track the tracer over time. The goal was to learn how the tracer beh…

This completed study looked at how common gut inflammation and leaky gut are in 80 adults with blood cancer who were in intensive care for sepsis or septic shock. Researchers measured two markers—calprotectin in stool and zonulin in blood—to better understand intestinal dysfuncti…

This study looked at whether a score called EASIX, which uses routine blood test results, can predict death and poor outcomes in people with sepsis. Researchers followed 150 adults in the intensive care unit for 28 days. The goal was to see if this score could help doctors identi…

This study looked at health records from over 5,700 adults in Japan with sepsis (blood poisoning) to see how many also developed a serious blood clotting disorder called DIC. Researchers collected information from hospital databases to track DIC rates and severity scores. The goa…

This study looked at 380 adults in the intensive care unit with suspected or confirmed COVID-19. Researchers tracked organ problems like kidney injury and lung failure, and measured survival rates at 30 days and one year. The goal was to learn how COVID-19 causes organ damage, no…

This study tested whether the dose of norepinephrine, a drug used to raise blood pressure, changes how well a non-invasive finger sensor (peripheral perfusion index) can predict tissue health in 80 septic shock patients. Researchers compared two dose levels to see if the sensor's…

This completed study looked at 30 patients with septic shock in the ICU. Researchers wanted to see how high doses of the drug norepinephrine affect not just large blood vessels, but also tiny ones (microcirculation). They used a non-invasive light-based device to measure oxygen l…

This study looked at the fluid between cells (interstitial fluid) in 26 intensive care patients with septic or non-septic shock. Researchers aimed to understand how this fluid changes during severe infections, which could help explain why swelling occurs and how to better manage …

This completed study looked at how the immune system is weakened after septic shock, severe trauma, burns, or major surgery. Researchers took blood samples from 552 patients and healthy volunteers to measure immune function. The goal was to find better ways to predict and manage …

This early-stage trial tested a new drug, M6229, in 15 healthy adults to see if it is safe and how the body processes it. Participants received either the drug or a placebo as a continuous 5-day infusion. The study is complete and focused on safety and drug levels, not on treatin…

This study looked at how platelets (small blood cells that help with clotting) become activated in people with septic shock, a life-threatening infection that causes organ failure. Researchers measured specific markers on platelets and platelet-white blood cell clumps in 27 patie…

This study looked at 1,529 intensive care patients with sepsis to see if a blood marker called procalcitonin (PCT) can help identify the type of bacteria causing the infection. Researchers measured PCT levels within 24 hours of a positive blood culture. The goal was to see if PCT…

This study tested whether carefully limiting fluids given for non-emergency reasons (like nutrition or drug dilution) could reduce fluid overload in intensive care patients with septic shock. 50 patients were randomly assigned to either the standard approach or a restrictive flui…

This completed Phase 4 study looked at how the body processes echinocandin antifungal drugs (caspofungin or micafungin) in 24 adults with septic shock caused by peritonitis. Researchers measured drug levels in the blood to understand clearance, distribution, and concentration. Th…

This study tested a handheld microscope to look at tiny blood vessels in 68 adults with sepsis or septic shock. The goal was to understand how these vessels break down during severe infection. The findings may help doctors design better treatments in the future.

This study looked at 192 adults with septic shock to see if a simple finger-pressure test (capillary refill time) could predict outcomes as well as a standard blood test (lactate level). Researchers measured both at the same time and tracked which patients got worse or died withi…

This study looked at 156 critically ill patients to find out what factors help achieve the right levels of beta-lactam antibiotics in the blood. Researchers collected clinical data and used therapeutic drug monitoring to see which patients reached target concentrations. The goal …

This study looked at whether a blood-filtering device called Efferon LPS removes antibiotics from the blood of people with sepsis. Sepsis is a severe infection that can lead to organ failure, and doctors sometimes use filters to clean the blood. The study included 30 patients and…

This study looked at 50 adults with septic shock to see how a sensitive heart ultrasound technique, called strain echocardiography, can track heart function changes. The goal was to understand if these measurements can help predict patient outcomes. The research did not test a tr…

This study looked at whether children with severe infectious shock develop immune suppression, similar to what is seen in adults. Researchers measured immune markers in 105 children admitted to intensive care and compared them to healthy children having surgery. The goal was to u…

This study tested a new scoring system that uses routine blood tests to predict the risk of death within one month for patients in intensive care with septic shock. Researchers looked at 780 patients to see how well the score works. The goal is to help doctors make faster, better…

This study looked at 145 patients with septic shock to see if the time when doctors check if a fluid bolus worked changes the results. Patients received 500 ml of fluid over 10 minutes. The study found that some patients who seemed to respond right away were no longer responding …

This study tested special wearable pumps (elastomeric pumps) to give antibiotics through a drip to hospital patients. Nine adults with bacterial infections took part to see if the pumps are safe, easy to use, and could save time and money compared to traditional methods. The goal…

This study looked at two ways to guide fluid treatment in 60 emergency department patients with septic shock: using ultrasound or a noninvasive heart monitor. Both methods aim to give the right amount of fluids to improve blood pressure and organ function. Researchers tracked sur…