Blood filtering procedure tested as new weapon against deadly sepsis
NCT ID NCT04057872
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This pilot study tested the safety of a blood-filtering procedure called therapeutic plasma exchange in 17 adults with septic shock, a life-threatening infection that causes organ failure. The procedure removes the liquid part of the blood and replaces it with fluids or donor plasma. The goal was to see if it could be done safely in this setting, with future studies needed to check if it actually helps patients recover.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- therapeutic plasma exchange (a procedure that removes and replaces blood plasma with fluids, albumin, or plasma)
- What this could lead to
- If this procedure proves safe and effective in larger studies, it could offer a new way to reduce organ failure and death from severe sepsis.
- What could go wrong
- This is a very small, early-phase safety study with only 17 participants. It is not designed to prove the treatment works, and side effects or lack of benefit are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Peter Lougheed Centre
Calgary, Alberta, T3M 1M4, Canada
-
South Health Campus
Calgary, Alberta, T3M 1M4, Canada
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Blood markers may foretell brain fog after sepsis
- Can tracking immune chaos in sepsis reveal new treatment targets?
- Blood clot score may predict organ damage in septic shock
- Could a key hormone be missing in septic shock?
- Could a simple mineral cut the need for powerful blood-pressure drugs in septic shock?
- Blood filter could shield vessels in septic shock