Could a common diabetes drug help kidneys in sepsis?
NCT ID NCT05900284
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether metformin, a common diabetes drug, is safe and practical to use for treating acute kidney injury caused by sepsis. Researchers gave low-dose metformin to 80 ICU patients with sepsis and kidney injury, monitoring for side effects and feasibility. The goal was to gather data for a larger future trial.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- metformin (low dose)
- What this could lead to
- If successful, this could point toward a new treatment for kidney injury in sepsis patients, potentially reducing deaths.
- What could go wrong
- This is a small, early-phase trial focused on safety and feasibility, not effectiveness. Metformin may cause side effects like low blood sugar or lactic acidosis in critically ill patients.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of Pittsburgh
Pittsburgh, Pennsylvania, 15261, United States
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