New fluid strategy aims to reduce organ failure in septic shock
NCT ID NCT03461900
First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This study tested a personalized approach to fluid management in 535 adults with septic shock. Doctors used a 'mini-fluid challenge'—a small amount of albumin given quickly—to check if more fluids would help, aiming to avoid fluid overload. The goal was to see if this tailored method could reduce organ failure compared to standard care.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
mini-fluid challenge (100 ml of 4% human serum albumin)
What this could lead to
If successful, this approach could help doctors better manage fluid levels in septic shock patients, potentially reducing organ damage and improving recovery.
What could go wrong
This is a completed trial, but the intervention is a management strategy, not a new drug. Benefits may be modest and depend on how well it's implemented in different ICUs.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Angers university hospital
Angers, France
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Besançon university hospital
Besançon, France
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Brest university hospital
Brest, 29200, France
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Brest university hospital
Brest, France
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Chartres Hospital
Chartres, 28000, France
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Clermont Ferrand university hospital
Clermont-Ferrand, France
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George Pompidou university hospital (APHP)
Paris, France
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Hôpital privé de l'ouest parisen
Trappes, 78190, France
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Kremlin Bicêtre university hospital (APHP)
Paris, France
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Le Mans hospital
Le Mans, France
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Marseille university horpital
Marseille, France
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Morlaix hospital
Morlaix, France
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Nantes university hospital
Nantes, France
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Nîmes university hospital
Nîmes, 30029, France
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Poitiers university hospital
Poitiers, France
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Rouen university hospital
Rouen, France
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Toulon hospital
Toulon, France
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Tours university hospital
Tours, France