New fluid strategy aims to reduce organ failure in septic shock

NCT ID NCT03461900

Completed Disease control Sponsor: University Hospital, Brest Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tested a personalized approach to fluid management in 535 adults with septic shock. Doctors used a 'mini-fluid challenge'—a small amount of albumin given quickly—to check if more fluids would help, aiming to avoid fluid overload. The goal was to see if this tailored method could reduce organ failure compared to standard care.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: mini-fluid challenge (100 ml of 4% human serum albumin)
What this could lead to: If successful, this approach could help doctors better manage fluid levels in septic shock patients, potentially reducing organ damage and improving recovery.
What could go wrong: This is a completed trial, but the intervention is a management strategy, not a new drug. Benefits may be modest and depend on how well it's implemented in different ICUs.

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Conditions

The condition(s) this trial relates to.

Edema toxic shock syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SEPTIC SHOCK

Contacts and locations

Locations

Angers university hospital

Angers, France
Besançon university hospital

Besançon, France
Brest university hospital

Brest, 29200, France
Brest university hospital

Brest, France
Chartres Hospital

Chartres, 28000, France
Clermont Ferrand university hospital

Clermont-Ferrand, France
George Pompidou university hospital (APHP)

Paris, France
Hôpital privé de l'ouest parisen

Trappes, 78190, France
Kremlin Bicêtre university hospital (APHP)

Paris, France
Le Mans hospital

Le Mans, France
Marseille university horpital

Marseille, France
Morlaix hospital

Morlaix, France
Nantes university hospital

Nantes, France
Nîmes university hospital

Nîmes, 30029, France
Poitiers university hospital

Poitiers, France
Rouen university hospital

Rouen, France
Toulon hospital

Toulon, France
Tours university hospital

Tours, France

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