Ambulance crews test early antibiotics for sepsis
NCT ID NCT03068741
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether paramedics can improve survival by giving antibiotics and fluids to sepsis patients before reaching the hospital. Over 2,000 adults with suspected sepsis and low blood pressure were enrolled. The goal was to see if early treatment in the field reduces deaths compared to usual care that starts in the emergency department.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Ceftriaxone (antibiotic) and intravenous saline (fluids)
What this could lead to
If it works, this could show that starting sepsis treatment in the ambulance saves more lives than waiting until arrival at the hospital.
What could go wrong
This is a completed Phase 4 trial, but the benefit of early paramedic treatment may be small or not apply to all sepsis patients. Risks include allergic reactions to antibiotics or fluid overload.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Halton Region Paramedic Services
Toronto, Ontario, Canada
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Peel Region Paramedic Services
Toronto, Ontario, Canada
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Toronto Paramedic Services
Toronto, Ontario, Canada
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York Region Paramedic Services
Toronto, Ontario, Canada