Ambulance crews test early antibiotics for sepsis
NCT ID NCT03068741
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether paramedics can improve survival by giving antibiotics and fluids to sepsis patients before reaching the hospital. Over 2,000 adults with suspected sepsis and low blood pressure were enrolled. The goal was to see if early treatment in the field reduces deaths compared to usual care that starts in the emergency department.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Ceftriaxone (antibiotic) and intravenous saline (fluids)
- What this could lead to
- If it works, this could show that starting sepsis treatment in the ambulance saves more lives than waiting until arrival at the hospital.
- What could go wrong
- This is a completed Phase 4 trial, but the benefit of early paramedic treatment may be small or not apply to all sepsis patients. Risks include allergic reactions to antibiotics or fluid overload.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Halton Region Paramedic Services
Toronto, Ontario, Canada
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Peel Region Paramedic Services
Toronto, Ontario, Canada
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Toronto Paramedic Services
Toronto, Ontario, Canada
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York Region Paramedic Services
Toronto, Ontario, Canada
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