Should vasopressor dosing be based on weight? new study investigates

NCT ID NCT04153578

Completed Knowledge-focused Sponsor: Methodist Health System Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed study looked at 945 patients with septic shock to compare two ways of dosing vasopressors (medicines that raise blood pressure): one based on the patient's weight, and one not. The goal was to see which approach leads to better outcomes and fewer side effects, especially in obese patients. The study measured total vasopressor exposure over 48 hours and tracked complications like death, arrhythmia, and blood clots.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: vasopressors (norepinephrine, epinephrine, phenylephrine, dopamine)
What this could lead to: If this study shows a clear benefit of one dosing strategy, it could help hospitals adopt safer, more effective vasopressor dosing for septic shock patients, especially those who are obese.
What could go wrong: This is an observational comparison, not a randomized trial, so it cannot prove cause and effect. Results may not apply to all hospitals or patient groups.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for SEPTIC SHOCK are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

Body Weight toxic shock syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SEPTIC SHOCK WEIGHT, BODY

Contacts and locations

Locations

Methodist Dallas Medical Center

Dallas, Texas, 75203, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.