Could lowering immune drugs save kidney transplants during ICU crises?

This study looks at whether reducing immunosuppressive medications can help kidney transplant patients recover from life-threatening infections in the intensive care unit. About 212 adult kidney transplant recipients who are admitted to the ICU with septic shock or severe breathing failure will be randomly assigned to either reduce their immune drugs or continue standard care. The goal is to see if this approach improves organ function without increasing the risk of transplant rejection.