University Hospital, Strasbourg, France

This study looks at whether using one or two antibiotics is better for treating a serious bloodstream infection caused by Enterococcus faecalis bacteria. The infection can be deadly, with a 15-25% risk of death. Researchers will compare the effects on death rates, treatment failu…

This study tests whether giving the blood thinner heparin before inserting a tube into the wrist artery can prevent blockage of that artery after a heart procedure. About 550 adults having a heart procedure through the wrist will be randomly assigned to get heparin either before …

This study looks at how well a non-surgical scope procedure works for fixing bile duct injuries that happen during gallbladder or liver surgery. About 220 adults who had this injury will be treated with an endoscope. The main goal is to see how many people get better right away a…

This study looks at a new way to fix a common elbow fracture in children using anchors with sutures instead of screws or pins. The goal is to reduce problems like hardware irritation and the need for a second surgery to remove implants. Nine children under 15 with displaced fract…

This study compares clindamycin, an antibiotic that can be taken by mouth and reaches bones and joints well, to other antibiotics for treating Streptococcus infections in artificial joints. Researchers will enroll 260 adults who had joint replacement surgery and developed an infe…

This study looks at whether a single surgery to replace an infected hip or knee joint works as well as the usual two-surgery approach for a rare fungal infection caused by Candida. The study will review medical records of 16 adults treated at one hospital. The goal is to see if o…

This study looks at two ways to treat multiple sclerosis (MS) in people who were diagnosed after turning 50. One approach starts with milder drugs and only uses stronger ones if needed, while the other starts with stronger drugs right away. The goal is to see which strategy bette…

This study tests if freezing desmoid tumors (cryoablation) works better than standard medications for people whose tumors have grown after initial monitoring. About 150 participants aged 13 and older will be randomly assigned to one of the two treatments. The goal is to stop tumo…

This study tests whether a special CT scan (dual-energy CT) works as well as MRI for staging mouth and throat cancers. If it does, patients may need one less scan, speeding up treatment and freeing up MRI machines. The study will enroll 30 adults with these cancers and compare th…

This study aims to see if a new blood test, Cryocheck HexLA, is better at detecting lupus anticoagulant (LA) than the current test. Lupus anticoagulant is a substance that can cause blood clots. Researchers will compare the two tests using blood samples from 200 adults. The goal …

This study looks at whether a simple decision-making flowchart can help general practitioners diagnose vertigo more accurately. Vertigo can be tricky to diagnose, and patients sometimes get the wrong referral. Researchers will compare the flowchart's diagnosis with the one made b…

This study aims to see how well specially trained dogs can detect bladder cancer just by smelling urine samples. About 340 adults scheduled for bladder surgery will provide urine samples for the dogs to sniff. The goal is to measure the dogs' accuracy, which could lead to a new, …

This study looks at whether two checklists (PERC and YEARS) can help doctors decide who really needs a CT scan for a blood clot in the lungs. Researchers will review records of 500 adults from one hospital's ER to see how many scans could have been avoided. The goal is to make di…

This study looks at whether giving pregnant women free organic vegetables and teaching them about healthy eating can lower their exposure to pesticides. About 210 pregnant women in Strasbourg, France, will take part. Researchers will measure pesticide levels in urine to see if th…

This study looks at two versions of a surgery for pectus excavatum, a condition where the chest is sunken. Researchers want to see if a modified technique leads to shorter surgery, less pain, and better appearance than the classic method. About 80 teenagers who had surgery betwee…

This study looks at how quickly blood thinners start working in ICU patients with serious pulmonary embolism (blood clots in the lungs). Researchers will review past records of 100 adults treated at one hospital to measure the time it takes to reach effective anticoagulation. The…

This study looks at whether taking metformin before being admitted to the intensive care unit (ICU) affects survival in people with type 2 diabetes who develop severe lactic acidosis. Researchers will review records of 100 adults admitted to a French hospital ICU between 2014 and…

This study reviews medical records of 2,450 women who had C-sections at Strasbourg University Hospital to find out why some still feel pain despite spinal anesthesia. Researchers will look for risk factors and how doctors managed the pain. The goal is to create a better preventio…

This study looks at mouth and tooth problems in people with rare diseases. Researchers want to collect information from 1300 patients to better understand these issues and improve diagnosis. The goal is to learn more, not to test a new treatment.

This study aims to understand why families refuse organ donation when asked. In France, many people support donation, but families say no 37% of the time, leading to a shortage of organs. Researchers will talk to families of 100 brain-dead patients in Strasbourg to learn the reas…

This study looks at whether a special MRI scoring system (O-RADS) can accurately tell if an ovarian mass in girls under 16 is cancerous or not. Researchers will review MRI scans and surgery results from 100 girls treated at two hospitals. The goal is to help surgeons choose the r…

This study looks at 100 adults who had incisional hernia repair to see if their physical activity before surgery affected their recovery. Researchers want to know if less active people have more or worse complications after the operation. The goal is to learn if being active can …

This study aims to find out what teenage girls (ages 11-18) with hypogonadism and their parents know about hormone replacement therapy. Researchers will use questionnaires to assess knowledge about the treatment's composition and effects. The goal is to identify gaps in understan…

This study reviews the records of 300 adults who visited the emergency department after a transient ischemic attack (TIA or mini-stroke). The goal is to see if the care they received—like tests and treatments—matched their actual risk of future strokes. Researchers hope to find g…

This study looks at whether changes in blood cell function and stress levels can help doctors detect and predict how pre-capillary pulmonary hypertension will progress. Researchers will collect blood samples from 120 patients during routine visits over 3 years and compare them wi…

This study tests a special MRI technique to find early brain changes in professional soccer players who may be at risk for chronic traumatic encephalopathy (CTE) from repeated headers. Researchers will compare brain scans of 80 male players aged 32-60 with those who have no histo…

This study looks at how sleep helps or hurts memory in children with certain types of epilepsy. Researchers will test memory in 95 children—some with epilepsy, some without—to see if epileptic brain activity during sleep causes them to forget more. The goal is to understand why l…

This study aims to better understand Lewy body disease, a brain disorder causing thinking and behavior problems that is often hard to diagnose. Researchers will analyze past EEG brain activity recordings from 40 adults to see if the brain's flexibility (how easily it changes stat…

This study reviews medical records of 221 people with advanced melanoma who received immunotherapy between 2013 and 2021. The goal is to find new clues that predict who will have a complete response, meaning all signs of cancer disappear. By understanding these factors, doctors m…

This study looks at whether having a total knee replacement as an outpatient (going home the same day) leads to better recovery compared to staying in the hospital overnight. Researchers will review medical records of 440 adults who had knee replacement surgery between 2020 and 2…

This study is tracking 100 children who come to the emergency room with visible blood in their urine. The goal is to understand what causes this common symptom and how doctors currently treat it. By gathering this information, researchers hope to create a standard care plan to he…

This study looks at whether common blood thinners (heparins) can cause lab tests to overestimate the level of another blood thinner (argatroban) when patients switch medications. Researchers will analyze blood samples from 70 adults already taking heparin to see if the test resul…

This study aims to find out how many adults with cystic fibrosis smoke or vape. Many people assume they don't, but there is little data. The results will help doctors improve prevention and understand how smoking or vaping might affect newer treatments like Kaftrio. About 100 adu…

This study looks at 50 adults with unexplained bleeding to see if low serotonin levels in their platelets play a role. Researchers will use a bleeding questionnaire to measure symptoms. The goal is to better understand how serotonin affects platelet function and bleeding risk.

This study looks at a rare condition called panniculitis, which is inflammation of the fat under the skin, in people who already have dermatomyositis. Researchers want to describe what this looks like and how it differs from similar conditions. About 20 people aged 1 and older wi…

This study looks at how doctors at Strasbourg University Hospital treat severe stomach or intestinal bleeding in patients who take blood thinners (DOACs). Researchers will review the records of 250 adults to see how often a clotting medicine called prothrombin complex concentrate…

This study looks at how different types of blood platelets change in adults who need ECMO support for severe heart or lung failure. Researchers will take blood samples on days 1, 3, and 7 after ECMO starts to track these changes. The goal is to better understand why some patients…

This study asks 50 pregnant women at the CMCO about their interest in and fears about ambulatory epidural anesthesia, a technique that allows some movement during labor. The goal is to understand patient views before offering this option at the hospital. No treatment is given—jus…

This study looks at 100 people in France who developed a severe form of Lyme disease (disseminated borreliosis) after receiving anti-CD20 treatment, a type of medication that suppresses the immune system. Researchers will describe the symptoms, severity, and progression of the in…

This study looks at whether a rectal swab can help predict which intensive care patients will get an infection from drug-resistant bacteria. Researchers will test 1000 adults in the ICU and track who later develops an infection. The goal is to see if a negative swab reliably mean…

This study surveys healthcare workers at European dialysis centers to learn how they measure pressure inside the belly (intraperitoneal pressure) in children receiving peritoneal dialysis. The goal is to understand current practices and improve how dialysis is prescribed. About 1…

This study looks at what helps or hinders creating care plans for vulnerable patients in medicalized residential care who need palliative care. Researchers will interview staff and patients to understand the organizational and human factors involved. About 100 adults in Alsace, F…

This study reviews the medical records of up to 115 transgender people who began medical support before age 18 at Strasbourg University Hospital. The goal is to describe their care and experiences. No new treatments are tested; instead, researchers will analyze past data to bette…

This study looks at people with systemic scleroderma who have a close family member with the same condition. Researchers want to learn how the disease runs in families, find clues about how it progresses, and identify possible targets for new treatments. About 20 adults will join…

This study looks at how well a tool called the HScore can diagnose hemophagocytic lymphohistiocytosis (HLH) in intensive care patients who also have liver failure or cirrhosis. Researchers will review medical records of 100 adults admitted to the ICU to see if the HScore accurate…

This study looks at how fatigue and muscle function are connected in people with axial spondyloarthritis, a type of inflammatory arthritis. Researchers will measure exercise capacity and muscle strength in 122 adults starting a new targeted therapy. The goal is to better understa…

This study looks at the risk of heavy bleeding in abortions performed between 14 and 16 weeks of pregnancy. Researchers will compare surgical and medical methods to see which is safer. The goal is to help patients and doctors make informed choices based on real-world data.

This study tracks 93 women with Turner Syndrome who wanted to become parents. Researchers will count how many succeeded through natural pregnancy, egg donation, or adoption. The goal is to understand the real-world success rate of having children for these women.

This study interviews 15 doctors in Alsace, France, who treat frail elderly patients with osteoporosis. The goal is to understand what makes them use (or not use) a practical guide on managing the condition. The findings could help improve how osteoporosis care is delivered to ol…

This study looks at whether nutrition is linked to better outcomes in adults with gastroenteropancreatic neuroendocrine tumors (NETs), a slow-growing cancer of the digestive system. Researchers will check 100 patients for signs of malnutrition and track their health over time. Th…

This study looks at 50 adults with metastatic bladder cancer who started first-line treatment after October 2024. Researchers want to understand why some patients receive platinum-based chemotherapy instead of the newer combination of Enfortumab Vedotin and Pembrolizumab. No new …

This study looks at blood clotting (hemostasis) values in 1,000 healthy premature infants from birth to 18 months. Researchers want to know what is normal for these babies and if it differs from full-term infants. The goal is to improve care by establishing reference ranges for t…

This study tests a simple questionnaire called AT HARM 10 to help pharmacists identify when a patient's hospital visit is caused by a medication problem. Researchers will enroll 100 adults over 65 in the emergency department to see how well the tool works. The goal is to improve …

This study looks back at 100 adults treated at Strasbourg University Hospital between 2014 and 2023 for a rare condition where an abnormal connection forms between the airway and digestive tract. The goal is to learn how long patients survive after diagnosis and what treatments w…

This study is looking at whether a PCR test for Aspergillus fumigatus (a fungus) in blood or lung fluid can help doctors predict how well treatment is working in patients with invasive aspergillosis, a serious lung infection. The study will include 100 adults diagnosed with this …

This study looks back at medical records of 60 adults with adrenal cortex carcinoma, a rare cancer. Researchers want to learn how the disease progresses and what affects survival. No new treatments are given; the goal is to gather information to improve future care.

This study looks at whether emergency department staff at Strasbourg University Hospital follow best practice guidelines when they use physical restraints on patients. Researchers will review records of 450 adults who were restrained between January and June 2023. The goal is to …

This study looks at one adult with severe hemophilia A who needs long-term blood thinners (anticoagulation). Hemophilia A is a bleeding disorder, so taking blood thinners is risky. The report will share how new clotting factor treatments help balance bleeding and clotting risks. …

This study looks at how the way doctors talk about breech birth affects a mother's choice between vaginal delivery and C-section. About 200 women who gave birth to a breech baby in 2024 at French university hospitals will answer a questionnaire about their satisfaction. The goal …

This study is observing 100 women with polycystic ovary syndrome (PCOS) in Alsace, France. The goal is to better understand the different types of PCOS and why diagnosis is often delayed. Researchers will measure things like obesity rates and insulin resistance. This study does n…

This study interviews 12 general practitioners in Bas-Rhin, France to find out what makes it hard to care for dying patients at home. Many people want to die at home, but obstacles like heavy workloads and emotional strain get in the way. The goal is to understand these barriers …

This study looks at how well a particular type of knee replacement (a fixed polyethylene posteriorly stabilized cemented total knee prosthesis) performs over at least one year. Researchers will review medical records and X-rays from about 960 adults who had this surgery between 2…

This study looks at whether a continuous glucose monitor (CGM) can detect early loss of function in transplanted pancreatic islets for people with type 1 diabetes. About 36 adults who have already received an islet transplant will wear a CGM for one year. The goal is to see if a …

This study looks at how occupational health doctors and nurses in France identify police officers who are struggling with mental health issues like depression, anxiety, or PTSD, and how they refer them to specialized care. About 200 health professionals will be interviewed to und…

This study looks at whether continuously monitoring oxygen levels while moving patients from the operating room to the recovery area can prevent dangerous drops in oxygen. About 30 adults having surgery will take part. Researchers will compare oxygen readings taken at the start a…

This study looks at children who had extra genetic testing (exome sequencing) during pregnancy because of ultrasound findings. Researchers want to see how these children develop after birth, especially when the test results were negative. The goal is to understand if a negative r…

This study looks at a newer method called cryobiopsy, which uses extreme cold to take tissue samples from the lungs. The goal is to see how safe and accurate it is for diagnosing conditions like lung disease, growths, or swollen lymph nodes in the chest. About 30 people who need …

This study surveys 100 healthcare professionals and students in Alsace, France, to understand their training, knowledge, and experience with organ donation. The goal is to find out if current training is sufficient, clear, and useful, and to identify areas for improvement. This i…

This study surveys 269 healthcare professionals in Alsace, France—including psychiatrists, midwives, and general practitioners—to understand their knowledge and practices around eating disorders during pregnancy and after childbirth. The goal is to identify gaps in care so that b…

This study looks at how a stay in the intensive care unit (ICU) affects a person's quality of life and risk of post-traumatic stress disorder (PTSD). Researchers will ask 40 adults who spent more than 48 hours in the ICU to fill out questionnaires about their experience and well-…

This study tests a new way to train neurosurgeons to repair brain aneurysms using human placentas. The placenta's blood vessels look and feel like those in the brain, making it a realistic practice tool. About 50 placentas from consenting mothers will be used to help surgeons imp…

This study looks at whether sleep disorders are linked to more severe vertigo in people with Ménière's disease, a condition causing hearing loss, ringing in the ears, and dizziness. Researchers will observe 100 adults to see if those with worse sleep also have more disabling vert…

This study examines 30 adults with psychotic disorders who are stable on long-term antipsychotics and want to reduce or stop their medication. Researchers will describe each person's experience to understand when and how deprescribing can work, including risks like relapse. The g…

This study looks at whether teaching delivery room staff how to better find and fix certain birth injuries can lower the chance of long-term anal incontinence. About 1,000 women who gave birth vaginally will be followed. The goal is to see if better training leads to fewer proble…

This study looks at people in France who have had recurrent borreliosis, a bacterial infection spread by ticks or lice. Researchers will describe the symptoms, where patients got the infection, and how it was diagnosed. The goal is to better understand this rare disease, not to t…

This study looks back at 500 adults who had total knee replacement surgery to see if the type of anesthesia (spinal or general) affects how well they recover. Researchers will use a patient questionnaire called QoR-15F to measure recovery. The goal is to find out which method lea…

This study looks at babies who fail their newborn hearing test to see if a common virus called CMV is the cause. CMV can lead to hearing loss and other health issues, but it often goes unnoticed. By collecting data from 450 infants, researchers hope to improve how we detect and m…

This study looks at whether high-speed centrifugation (spinning blood very fast) can separate fat from plasma to allow accurate measurement of anti-Xa activity, a test that monitors blood thinners. About 150 adults on blood thinners will have their samples tested. The goal is to …

This study looks back at how antithrombin, a blood protein that helps prevent clots, was prescribed to 160 adult patients in intensive care or operating rooms at Strasbourg University Hospitals over one year. The goal is to understand if these prescriptions were appropriate and h…

This study looks back at medical records of 100 adults in Alsace, France, who had a confirmed anaplasmosis infection. The goal is to learn more about the disease's symptoms, complications, and death rates in this region. No new treatments are being tested; instead, researchers ho…

This study looks back at medical records of 50 adults recently diagnosed with HIV to see if doctors missed warning signs during earlier visits. The goal is to understand why HIV testing wasn't done sooner and how to improve early detection. No new treatments or tests are given—ju…

This study looks at whether giving parents an easy-to-understand information sheet after their child's first simple febrile seizure can reduce worry and unnecessary trips to the emergency room. About 100 children aged 9 months to 5 years who had a first simple febrile seizure wil…

This study looks at how to better choose antibiotics for people with reported beta-lactam allergies (like penicillin) during orthopedic surgeries like knee or hip replacements. Many people are labeled allergic but aren't truly allergic, leading to wrong antibiotic use. Researcher…

This study looks at whether chest CT scans can predict how well patients with a rare, serious lung infection called pulmonary mucormycosis will do. Researchers will review scans from 80 patients treated at a French hospital to find patterns linked to better or worse outcomes. The…

This study looks at medical records of 400 adults hospitalized with a severe strep bloodstream infection. The goal is to find out which factors are linked to a higher risk of death within 28 days. By identifying these factors, doctors hope to better predict and prevent fatal outc…

This study looks at whether certain medications that alter gut bacteria can impact how well immunotherapy works in people with advanced lung cancer. Researchers will review records from 800 adults with stage III-C or IV non-small cell lung cancer who received immunotherapy. The g…

This study is testing a simple questionnaire (called SCST) to measure how severe allergic rhinitis (hay fever) is in patients visiting an ear, nose, and throat (ENT) clinic. About 30 adults with allergic rhinitis will fill out the questionnaire to see if it is easy to use and giv…

This study looks back at medical records of 30 adults with weakened immune systems (from organ transplants, cancer, or certain medications) who also had toxoplasmosis. The goal is to learn how many people are affected and how to better diagnose, treat, and prevent this infection.…

This study looks at using a special ultrasound (liver elastography) to measure liver scarring in children with type III glycogen storage disease, a rare condition that can lead to serious liver problems. Researchers will review past elastography results from 30 participants aged …

This study looks at whether elderly patients (75+) with acute medical problems have better outcomes when they go directly to a regular hospital ward from the emergency room, or when they first spend time in a short-stay unit. Researchers will track 2,000 patients to compare 3-mon…

This study aims to understand how patients live and recover after surviving acute mesenteric ischemia, a severe and life-threatening abdominal emergency. It will follow 100 adults who were treated for this condition between 2010 and 2022. The main goal is to measure their long-te…