University Hospital, Strasbourg, France

This study tests whether reducing immunosuppressive drugs (along with giving a steroid) helps kidney transplant patients recover from septic shock or severe breathing failure in the ICU. About 212 adults whose transplant was at least 3 months ago will be randomly assigned to eith…

This study is testing whether giving the blood thinner heparin before inserting a tube into the wrist artery can prevent a common complication: blockage of that artery. About 550 people undergoing a heart procedure through the wrist will be randomly assigned to receive heparin ei…

This study tests whether eating small, increasing amounts of raw apple can reduce mouth allergy symptoms in people who are allergic to both birch pollen and apples. 110 participants will eat either real apple or a placebo over 9 months. The goal is to see if they can tolerate a l…

This study looks at how well a non-surgical endoscopic treatment works for people who have bile duct injuries from gallbladder or liver surgery. Researchers will track 220 adults to see how many get better after the procedure and stay better for at least 3 months. The goal is to …

This study looks at a new way to fix a common elbow fracture in children using anchors with sutures instead of screws or pins. The goal is to reduce problems like hardware irritation and the need for a second surgery to remove implants. Nine children under 15 with displaced fract…

This study looks at whether the antibiotic clindamycin works as well as other drugs for treating Streptococcus infections in artificial joints. Researchers will compare success rates in 260 adults who had surgery for this infection. The goal is to see if clindamycin can be a good…

This study looks at whether a single surgery to replace an infected hip or knee joint can work as well as the usual two-step process for Candida infections. Researchers will review records of 16 patients treated between 2013 and 2021. The goal is to see if the infection clears up…

This study tests whether freezing desmoid tumors with a needle (cryoablation) works better than standard chemotherapy for people whose tumors have grown after a period of watchful waiting. About 150 participants will be randomly assigned to one of the two treatments. If the tumor…

This study is testing whether a new, more detailed DNA reading technique (long-read genome sequencing) can find genetic causes of dystonia that standard tests miss. Researchers will analyze blood samples from 150 people with dystonia and their family members. If it works, this co…

This study tests whether a special type of CT scan (dual-energy CT) can be as good as MRI for staging oral and throat cancers. Staging helps doctors decide the best treatment. If the CT works just as well, patients might avoid an extra MRI, get treated faster, and free up MRI mac…

This study is testing whether specially trained dogs can detect bladder cancer by smelling urine samples. Researchers will collect urine from 340 adults scheduled for bladder surgery and see how often the dogs correctly identify cancer. If it works, this could lead to a simple, n…

This study is testing a new blood test called Cryocheck HexLA to see if it can detect lupus anticoagulant (LA) more accurately than current tests. Researchers will compare the new test with standard tests using blood samples from 200 adults. The goal is to find a test that is bot…

This study looks at whether two simple checklists (PERC and YEARS) can safely reduce the number of CT scans needed to diagnose pulmonary embolism (a blood clot in the lungs). Researchers will review the records of 500 adults who came to the emergency room with suspected clots. If…

This pilot study is testing a new MRI technique called brainQuant to see if it can find early signs of brain damage in professional soccer players. Repeated headers may cause tiny brain injuries that lead to chronic traumatic encephalopathy (CTE). The study will scan 80 male socc…

This study tests a simple flowchart designed to help general practitioners diagnose vertigo and decide when to refer patients to an ear, nose, and throat (ENT) specialist. Researchers will compare the flowchart's diagnosis with the ENT doctor's final diagnosis in 50 patients. The…

About 30% of people who have surgery for a herniated disc still suffer from nerve pain afterward. This study tests whether applying a gel made from the patient's own blood (platelet-rich fibrin) around the nerve during surgery can prevent that chronic pain. The trial will enroll …

This study tests whether giving pregnant women a weekly basket of organic vegetables for two weeks reduces their exposure to pesticides compared to women who eat as usual. Researchers will measure pesticide levels in urine before and after the program. If successful, it could sup…

This study tests whether a mother's voice, touch, and care can reduce pain in very premature newborns during a common blood draw (venipuncture). 48 babies born before 32 weeks will be studied at one hospital. Researchers will compare pain scores when standard non-drug methods are…

This study tests whether dialectical behavior therapy (DBT), a type of talk therapy, can help people with acquired brain injury manage emotional distress and challenging behaviors. 77 participants will receive standard care for 5 months, then DBT for 5 months, then follow-up. Res…

This study tests whether a personalized facial rehabilitation program can help people with systemic sclerosis who have facial tightness and mouth problems. About 60 adults with this rare autoimmune disease will either receive the rehab program or standard care. The goal is to see…

This study looks at mouth and tooth problems in people with rare diseases. Researchers will collect saliva, blood, and medical history from 1300 participants to better understand these issues. The goal is to improve diagnosis and care, not to test a new treatment.

This study follows 36 people with type 1 diabetes who have received a pancreatic islet transplant. Researchers will use continuous glucose monitors to see if a measure called 'Time in Tight Range' can detect early loss of graft function. The goal is to find a simple way to spot p…

This study looks at why people with axial spondyloarthritis often feel very tired and how that relates to muscle function. Researchers will measure exercise capacity in 122 adults starting a new targeted therapy. The goal is to better understand the connection between fatigue and…

This study surveys 100 French dentists who treat children to understand why they often choose extraction for non-vital baby teeth, even though effective alternatives like pulpectomy exist. The goal is to collect and analyze their treatment choices, reservations, and decision-maki…

This study surveys 100 healthcare professionals and students in Alsace, France, to understand their training, knowledge, and experience with organ donation. The goal is to find out if current training is sufficient, clear, and useful, and to identify misconceptions that may hinde…

This study is testing a newer technique called cryobiopsy, which uses a freezing probe to take tissue samples from the lungs. The goal is to see how safe and accurate it is for diagnosing conditions like lung disease, tumors, or infections. Researchers at a French hospital will s…

This study looks at how a stay in the intensive care unit (ICU) affects a person's quality of life and risk of post-traumatic stress disorder (PTSD). Researchers will ask 40 adults who spent more than 48 hours in the ICU to fill out questionnaires about their experience and curre…

This study asks 50 pregnant women at a French hospital about their interest in and worries about ambulatory (walking) epidural anesthesia, a technique that allows more movement during labor. The goal is to understand what patients expect and fear, so the hospital can better intro…

This study aims to describe a rare condition called panniculitis (inflammation of the fat under the skin) in people with dermatomyositis. Researchers will examine 20 participants aged 1 year and older to identify unique clinical and microscopic features. The goal is to better dis…

This study looks at how emergency departments handle patients who have had a transient ischemic attack (TIA), also known as a mini-stroke. Researchers will review records of 300 adults diagnosed with TIA in 2024 to see if the care they received—like tests and treatments—matched t…

This study looks at 20 adults with systemic scleroderma who have a family history of the disease. Researchers will describe their symptoms and progression to find clues about how the disease works and identify markers that could lead to new treatments. The goal is to learn more, …

This study follows 93 women with Turner syndrome who wanted to become parents. Researchers will track how many succeeded through natural pregnancy, egg donation, or adoption. The goal is to understand the real-world chances of parenthood for these women.

This study surveys healthcare professionals in European dialysis centers to understand how they measure intraperitoneal pressure (belly pressure) in children with kidney failure who are on peritoneal dialysis. The goal is to learn about current practices and improve how dialysis …

This study is observing 100 women with polycystic ovary syndrome (PCOS) in Alsace, France. Researchers want to understand why diagnosis is often delayed and how the condition varies from person to person. They will measure things like obesity rates and insulin resistance. No new …

This study interviews staff and caregivers at two medicalized residential facilities in Alsace, France, to understand what helps or hinders creating care plans for vulnerable patients receiving palliative care. Researchers will analyze conversations to identify key factors like s…

This study looks at whether a tool called the HScore can accurately diagnose hemophagocytic lymphohistiocytosis (HLH) in intensive care patients with liver failure or cirrhosis. Researchers will review medical records of 100 adults admitted to one hospital over ten years who had …

This study looks at why some people with advanced bladder cancer receive older platinum-based chemotherapy instead of a newer, more effective drug combination. Researchers will review the medical records of 50 patients to understand the reasons behind these treatment choices. The…

This study looks at blood clotting (hemostasis) in 1,000 healthy premature babies born before 37 weeks. Researchers want to know what normal clotting values are from birth to 18 months old, and whether they differ from full-term babies. The goal is to help doctors better interpre…

This study looks at cases of severe Lyme disease (disseminated borreliosis) in patients who have received anti-CD20 therapy, a type of immune-suppressing treatment. Researchers want to describe the symptoms, severity, and progression of the infection in these patients. The study …

This study surveys 269 healthcare professionals in Alsace, France, including psychiatrists, midwives, and general practitioners, to understand their knowledge and practices around eating disorders during pregnancy and the postpartum period. The goal is to identify gaps in care an…

This study examines whether chest CT scans can help predict how patients with a rare but severe lung fungal infection called pulmonary mucormycosis will fare. Researchers will review scans from 80 patients treated at a French hospital to identify imaging patterns linked to better…

This study looks at 30 adults with psychotic disorders who are stable on long-term antipsychotics and want to reduce or stop their medication. Researchers will describe real-life cases to understand what works, what doesn't, and the risks of relapse. The goal is to learn practica…

This study is surveying 100 adults with cystic fibrosis to find out how many smoke or vape. Many people assume that patients with cystic fibrosis don't smoke, but there is almost no data on this. The results will help doctors improve tobacco prevention and understand how smoking …

This study looks at whether a rectal swab can predict which intensive care patients will get infections from drug-resistant bacteria. Researchers will test 1,000 adults in French ICUs to see how often a negative swab correctly rules out future infection. The goal is to help docto…

This study aims to improve how doctors choose antibiotics for patients who say they are allergic to penicillin-like drugs (beta-lactams) before orthopedic surgery. Many people think they are allergic, but only a small fraction truly are. Researchers will use a simple questionnair…

This study looks at children whose parents had an extra genetic test (exome sequencing) during pregnancy because of ultrasound findings. Researchers want to see how these children develop after birth, especially when the test came back negative. The goal is to learn if a negative…

This study is looking back at medical records of 400 adults hospitalized with a serious strep blood infection (Streptococcus anginosus group). The goal is to find out which factors are linked to a higher chance of dying within 28 days. By understanding these risk factors, doctors…

This study looks at why families refuse organ donation when asked, even though most people support it. Researchers at Strasbourg University Hospital will talk to families of 100 brain-dead patients to understand their reasons. The goal is to reduce refusals and help more people g…

This study looks back at 100 cases of human babesiosis, a rare tick-borne disease, diagnosed in France between 2000 and 2024. Researchers want to describe who gets it, what symptoms they have, and how they are treated. The goal is to improve recognition and care, especially for v…

This study looks at how doctors currently screen and treat obstructive sleep apnea in children with Down syndrome at one hospital. By reviewing past records of 30 children, researchers hope to create a standard care plan that can be used across France. The goal is to improve brea…

This study tests whether giving parents an explanatory sheet after their child's first simple febrile seizure reduces repeat emergency visits and eases anxiety. About 100 parents of children aged 9 months to 5 years will receive the sheet. The goal is to see if better education c…

This study looks at how doctors at Strasbourg University Hospital manage severe stomach or intestinal bleeding in patients taking blood thinners (DOACs). Researchers will review medical records of 250 adults to see how often a drug called prothrombin complex concentrate is used t…

This study looks at how often physical restraint is used in the emergency departments of Strasbourg University Hospital according to best practice guidelines. Researchers will review 450 adult patients who were restrained between January and June 2023. The goal is to see if docto…

This study looks at whether a questionnaire called AT HARM 10 can help identify emergency room visits caused by medication problems in adults over 65. Researchers will test the tool on 100 patients at one hospital to see how many drug-related issues they can find. The goal is to …

This study looks back at the medical records of 400 full-term newborns who had very low cord blood pH (a sign of severe oxygen shortage during birth). Researchers want to find specific heart rate patterns that show when a baby is struggling and needs help. The goal is to help doc…

This study looks back at cases of recurrent borreliosis, a bacterial infection spread by ticks or lice, diagnosed in France between 2013 and 2025. Researchers will describe the symptoms, where patients got infected, which Borrelia species caused the illness, and how it was diagno…

This study looks at how different types of platelets change in patients on ECMO, a machine that helps the heart and lungs. Researchers will track 75 adults in intensive care to see if shifts in platelet populations relate to bleeding or clotting problems. The goal is to better un…

This study compares the risk of heavy bleeding between surgical and medical abortions performed at 14 to 16 weeks of pregnancy. Researchers at Strasbourg University Hospital will enroll 50 adult women to see which method leads to fewer cases of blood loss over 500 cc. The goal is…

This study collects information from 450 newborns who fail their initial hearing screening. Doctors will test them for congenital CMV, a common infection that can cause hearing loss and other problems. The goal is to see how often CMV is found and to improve follow-up care for af…

This study looks at how flexible brain activity is in people with Lewy body disease, a condition that causes thinking and behavior problems and is often hard to diagnose. Researchers will analyze past EEG recordings from 40 adults to see if certain brain patterns are linked to th…

This study looks at whether teaching delivery room staff how to better find and fix tears during childbirth can lower the chance of women having anal incontinence later. About 1,000 women who gave birth vaginally at a French hospital will be followed. The goal is to see if better…

This study looks back at the medical records of 60 adults treated for adrenal cortex carcinoma at a French hospital. Researchers want to learn more about the disease's features and how long patients live after treatment. The goal is to better understand this rare cancer and impro…

This study at Strasbourg University Hospital surveys 20 teenage girls (ages 11-18) with female hypogonadism and their parents to assess their knowledge of hormone replacement therapy. The goal is to identify gaps in understanding so that better educational workshops can be design…

This study is testing whether a simple symptom score questionnaire (SCST) is acceptable and useful for patients with allergic rhinitis during ENT check-ups. The goal is to see if this tool helps doctors monitor severity and response to treatment consistently. Thirty adults will p…

This study looks back at medical records of 50 adults in France who were diagnosed with HIV between 2021 and 2024. Researchers want to find out if doctors missed signs of HIV during visits in the year before diagnosis. The goal is to understand why testing is delayed and help cat…

This study reports on a single adult with severe hemophilia A who is receiving long-term anticoagulation (blood thinners). The goal is to see if newer factor VIII therapies can maintain safe clotting levels while preventing dangerous clots. Only one participant is enrolled, so th…

This study is testing whether continuously monitoring oxygen levels while patients are moved from the operating room to the recovery room can reduce the number of times oxygen drops too low. Researchers will compare oxygen readings taken at the start and end of transport, and the…

This study looks at whether measuring Aspergillus fumigatus DNA in blood or lung fluid can help predict outcomes in patients with invasive aspergillosis, a serious fungal lung infection. Researchers will track 100 adults to see if changes in PCR levels during treatment relate to …

This study looks at whether a special MRI scoring system called O-RADS can accurately tell if an ovarian mass in girls under 16 is cancerous or not. Researchers will review the MRIs of 100 girls who had surgery for ovarian masses at two hospitals. The goal is to see if this tool …

This study looks at how the way doctors talk about breech birth affects a mother's decision to have a vaginal delivery or a planned C-section. Researchers will survey 200 women who gave birth to a breech baby in 2024 at French university hospitals, along with their doctors. The g…

This study looks at two ways to treat multiple sclerosis (MS) when it first appears after age 50. One approach starts with a moderate-strength drug and only switches to a stronger one if needed. The other starts with a strong drug right away. Researchers will compare how often re…

This study looks at how well a particular type of knee replacement works in 960 adults who had surgery between 2013 and 2024. Researchers will check knee function and X-ray results at least one year after surgery. The goal is to see how the prosthesis performs and compare it to o…

This study compares two versions of the Nuss surgery for pectus excavatum (sunken chest) in teenagers aged 11 to 18. Researchers will look at 80 patients' records to see which technique leads to shorter surgery, less pain, and better cosmetic results. The goal is to help surgeons…

This study collects information from about 100 adults in Alsace who have had a confirmed case of human anaplasmosis, a bacterial infection spread by ticks. Researchers want to learn more about how common it is, what symptoms people have, and how serious it can be. The goal is to …

This study looks at 100 children under 18 who come to the emergency room with visible blood in their urine. The goal is to list the different causes and see how doctors currently manage this symptom. No new treatments are tested; the aim is to gather information to create better …

This study reviews medical records of 2,450 women who had C-sections at a French hospital to find out why some still feel pain despite spinal anesthesia. Researchers aim to identify risk factors and improve pain management. No new treatments are tested—just learning from past cas…

This study tests whether a fresh human placenta can be used as a realistic model for training neurosurgeons to repair brain aneurysms. The placenta's blood vessels closely resemble those in the brain, and researchers will create artificial aneurysms using a small catheter. The go…

This study interviews 15 doctors in Alsace, France, who treat elderly patients with osteoporosis and have used a practical guide on the condition. The goal is to find out what helps or prevents them from using the guide in their daily practice. By understanding these factors, res…

This study reviews medical records of 221 people with advanced melanoma who received immunotherapy between 2013 and 2021. The goal is to find new factors that predict which patients achieve a complete and lasting response. Participants must be 18 or older and have received treatm…

This study looks at how people feel and function after surviving a severe abdominal emergency called acute mesenteric ischemia. Researchers will ask 100 adults treated at Strasbourg University Hospitals between 2010 and 2022 to fill out a quality-of-life questionnaire. The goal i…

This study looks at 50 adults with unexplained bleeding to see if low serotonin levels in their platelets are linked to their symptoms. Researchers will use a standard bleeding questionnaire to measure bleeding severity. The goal is to better understand how serotonin deficiencies…

This study looks at using liver elastography, a non-invasive ultrasound-like technique, to measure liver fibrosis in children with type III glycogen storage disease (GSDIII). The goal is to see if this method can replace painful liver biopsies for monitoring disease progression. …

This study at Strasbourg University Hospital will check the nutritional status of 100 adults with gastroenteropancreatic neuroendocrine tumors. Researchers want to see if malnutrition is linked to worse outcomes. The goal is to understand whether improving nutrition could help pa…

This study looks at whether common blood thinners like heparin can mess up lab tests for another blood thinner, argatroban. Doctors often switch patients from heparin to argatroban, but current tests can't tell the two drugs apart. Researchers will analyze blood samples from 70 a…

This study looks at people aged 75 and older who come to the emergency room with a medical problem and need to be admitted to the hospital. It compares two groups: those sent directly to a regular hospital ward versus those who first go to a short-stay unit. The main goal is to s…

This study looks at whether sleep disorders make vertigo worse for people with Ménière's disease, a condition that causes hearing loss, ringing in the ears, and dizziness. Researchers will track 100 adults to see if those with more severe vertigo also have more sleep problems. Th…

This study looks back at 100 adults treated for aerodigestive fistulas at Strasbourg University Hospital between 2014 and 2023. These rare connections between the airway and digestive tract can cause serious infections. Researchers aim to understand survival rates and improve fut…

This study looks back at medical records of 30 non-HIV patients with weakened immune systems who had toxoplasmosis, a brain infection. The goal is to understand how many are affected and how to better diagnose and treat them. Researchers will track survival rates to improve care …

This study looks at 700 adults with Enterococcus faecalis bloodstream infection, a condition with a 15-25% death rate. Researchers compare patients who received one antibiotic versus a combination of antibiotics to see which approach reduces deaths and complications. The goal is …

This study looks at 100 adults with type 2 diabetes who were admitted to the ICU with severe lactic acidosis. Researchers want to see if taking metformin before admission affects their chances of survival. The goal is to better understand the role of this common diabetes drug in …

This study looks at how occupational health doctors and nurses in France identify police officers who may be struggling with mental health issues like depression, anxiety, or PTSD, and how they refer them to specialized care. About 200 health professionals who work with national …

This study looks at 100 adults hospitalized in the ICU for a serious pulmonary embolism (a blood clot in the lung). Researchers want to know how long it takes for the blood thinner (unfractionated heparin) to reach a level that prevents more clots. They will also check if faster …

This study looks back at how antithrombin, a blood-clotting protein, was prescribed to 160 intensive care patients at Strasbourg University Hospitals over two years. Researchers want to see if these prescriptions were appropriate and how the drug was used in real-world settings. …

This study looks at whether having total knee replacement surgery as an outpatient (going home the same day) leads to better recovery compared to staying in the hospital. Researchers will review medical records of 440 patients who had knee replacement between 2020 and 2023 at a F…

This study looks at 500 people who had total knee replacement surgery to see if recovery is better with spinal anesthesia or general anesthesia. Researchers will compare recovery scores from a questionnaire. The goal is to find out which method helps patients recover faster after…

This study looks at medical records of 20 adults who had bariatric surgery and later received treatment for alcohol use disorder. Researchers want to understand if and how the surgery was considered during addiction follow-up. The goal is to improve care for patients with both co…

This study looks at how sleep affects memory in children with certain types of epilepsy. Researchers will test memory before and after sleep in 95 children, comparing those with mild epilepsy, severe epilepsy, and no epilepsy. The goal is to see if epileptic brain activity during…

This study tests whether spinning blood samples at very high speed can remove fat particles that interfere with a key test for blood thinners. Researchers will add fat to routine blood samples from 150 adults on anti-Xa medications and see if the spinning method clears the fat wi…

This study looks at whether people who are more physically active before incisional hernia surgery have fewer problems afterward. Researchers will track 100 adults who already had the surgery and see if their activity level relates to complications. The goal is to understand if b…

This study surveys 100 doctors and trainees in France to assess their knowledge of tick-borne encephalitis, a rare but serious viral infection spread by ticks. The goal is to see if doctors in high-risk areas are more aware than those elsewhere, and to identify gaps that could im…

This study looks at whether certain drugs that change the gut bacteria (like antibiotics or acid reducers) can affect how well immunotherapy works in people with advanced lung cancer. Researchers will review medical records from 800 patients to see if those who took these drugs h…

This study looks at whether medical students in their final year find it acceptable to receive training on how to certify a death and how to tell a family that their loved one has died. Twenty students from the University of Strasbourg will be asked about their views. The goal is…

Most people say they want to die at home, but many end up in hospital. This study interviews 12 general practitioners in Bas-Rhin, France, to understand what makes home-based palliative care difficult. The goal is to identify obstacles like workload and emotional strain, and find…

This study looks at whether the way blood cells work and handle stress can help doctors detect and predict the course of pre-capillary pulmonary hypertension, a serious lung condition. Researchers will collect blood samples from 120 patients during routine visits over three years…

This study will review the medical records of transgender minors who started medical support before age 18 at Strasbourg University Hospital. Researchers aim to describe the characteristics and care provided to this group. The study is purely observational, looking back at past d…