University Hospital, Strasbourg, France

This study is testing whether a drug called sivelestat can help restore normal blood clotting in ICU patients with septic shock who develop dangerous blood clotting problems. The trial will involve 120 patients who will receive either the drug or a placebo to see if sivelestat im…

This study compares two surgical approaches for treating high-risk endometrial cancer. Researchers want to see if a less invasive method that maps and removes only key lymph nodes works as well as the current standard of removing many lymph nodes. The goal is to reduce surgery co…

This study aims to find a safer way for stable schizophrenia patients to reduce their antipsychotic medication, as many request this but doctors lack clear guidelines. Researchers will test if a personalized approach, based on a patient's specific psychotic symptoms, makes dose r…

This study tests if people with a first-time collapsed lung can safely go home with a chest tube instead of staying in the hospital. It will compare the quality of life, recovery, and costs for about 386 patients who are either sent home or receive usual hospital care. The main g…

This study is testing whether a personalized version of a psychological training program works better than the standard version for people with schizophrenia. It will involve 51 adults in France who have stable symptoms. Researchers will use machine learning to customize the ther…

This study aims to find a better way to treat kidney transplant patients who become critically ill with severe infections like septic shock. It will test whether temporarily lowering their anti-rejection medications helps their bodies fight the infection and recover in the intens…

This study tests whether a specialized therapy called Dialectical Behavior Therapy (DBT) helps people with addiction and emotional regulation problems. It will compare two ways of delivering the therapy—traditional in-person groups and an online video-based format—against usual t…

This study aims to develop a better test to tell the difference between two common brain diseases: Lewy body dementia and Alzheimer's. Researchers will test a new method that looks for a specific, harmful protein in spinal fluid from 286 people who already show signs of one of th…

This study is testing a more advanced genetic test to find the hidden causes of severe epilepsy in children. It will enroll 20 children whose epilepsy has no known genetic cause despite previous standard testing. The goal is to see if this new technology can provide answers that …

This study aims to find the safest, smallest amount of dye needed for clear brain scans to check for aneurysms. Researchers will compare the standard dye injection method to three new methods that use less dye or a slower injection. The goal is to reduce patient risk from the dye…

This study is testing whether 3D models created from a standard CT scan (without contrast dye) are as accurate as models from a contrast CT scan for planning a precise type of lung cancer surgery. It will involve 50 adults with early-stage lung cancer who are eligible for minimal…

This study is testing whether immersive virtual reality (VR) can help reduce pain, anxiety, and fatigue for people receiving palliative care. Forty patients will be randomly assigned to use either a fully immersive VR headset or a less immersive control headset for 10 minutes dai…

This study is testing whether using a virtual reality headset with calming audio can help reduce anxiety and pain for adults having their wisdom teeth pulled. It will compare patients who use VR during the procedure to those who receive only the standard local anesthetic. The goa…

This study is testing whether a long-acting melatonin pill can help children and teenagers with PTSD who have serious, ongoing sleep problems like trouble falling asleep, frequent waking, or nightmares. Researchers want to see if improving sleep also helps reduce daytime PTSD sym…

This study tests whether adding personalized nurse follow-up to standard care improves recovery after surgery for patients with complex health needs. The nurses will focus on patients' own reports of their symptoms and recovery progress. Researchers aim to see if this approach he…

This study is testing whether combining hypnosis with calming scents (aromatherapy) can help reduce anxiety in people going through alcohol withdrawal. Researchers will compare this combined approach to standard hospital care. The study will involve 80 adults hospitalized for alc…

This study aims to better understand the fatigue experienced by people with Charcot-Marie-Tooth type 1A (CMT1A), a genetic nerve disorder. Researchers will measure how fatigue affects walking and balance by comparing 44 people with CMT1A to healthy volunteers using special tests …

This study aims to understand how blood clotting works in cancer patients who develop serious bleeding disorders. Researchers will measure specific blood proteins in 150 hospitalized patients with blood cancers, solid tumors, or severe infections. The goal is to find early signs …

This study aims to find out if a simple blood test can predict dangerous bleeding in critically ill patients on ECMO life support. Researchers will track 100 patients in intensive care to see if changes in a blood marker called D-dimer can signal a high risk of bleeding within 24…

This study aims to gather information to see if a future treatment for severe leg artery disease is possible. Researchers will compare blood samples from 50 patients with different stages of the disease to check for a specific protein target used by some diabetes drugs. The goal …

This study aims to understand the psychological experience of parents who receive a positive or false-negative result from newborn screening for spinal muscular atrophy (SMA). Researchers will interview parents and ask them to complete questionnaires about their stress, anxiety, …

This French study aims to better understand how autoimmune diseases like lupus and scleroderma start. Researchers will analyze blood samples from 200 patients to identify and measure specific 'rogue' immune cells that mistakenly attack the body. The goal is to gather knowledge ab…