University Hospital, Strasbourg, France

This study looks at whether people with schizophrenia who are stable on medication can safely lower their dose and still function well in daily life. Researchers will group 288 adults by their specific psychosis type and randomly assign them to either reduce or maintain their cur…

This study tests whether dapagliflozin, a drug usually used for diabetes, can help people with septic shock—a life-threatening condition where blood flow to small blood vessels fails. About 568 adults in intensive care will receive either dapagliflozin or a placebo, alongside sta…

This study tests a drug called sivelestat in 120 adults with septic shock and blood clotting problems. The drug aims to restore the body's ability to break down small blood clots, which may reduce organ damage. Participants will receive either sivelestat or a placebo, and researc…

This study looks at whether reducing immunosuppressive medications can help kidney transplant patients recover from life-threatening infections in the intensive care unit. About 212 adult kidney transplant recipients who are admitted to the ICU with septic shock or severe breathi…

This study compares two surgical approaches for people with early-stage, high-risk endometrial cancer that has a p53 mutation. One group will have a standard surgery that removes many lymph nodes, while the other will have a less invasive procedure that only removes a few key lym…

This study tests whether measuring a specific form of a protein called alpha-synuclein in spinal fluid can accurately tell apart two common dementias: Lewy body dementia and Alzheimer's disease. About 286 adults aged 50 and older with signs of either condition will have a lumbar …

This study looks at whether treating a first-time collapsed lung (pneumothorax) at home, instead of staying in the hospital, can improve quality of life. About 386 adults aged 18 to 50 will be randomly assigned to either outpatient care or standard inpatient care. The main goal i…

This study explores whether using a virtual reality (VR) headset can help reduce pain, anxiety, and fatigue in people receiving palliative care. Forty adults with complex needs will be randomly assigned to either a fully immersive VR experience or a less immersive version for 10 …

This study looks at whether dialectical behavior therapy (DBT) can help people with addiction who also have trouble managing their emotions. About 120 adults will either get DBT in a group, DBT online with videos, or their usual treatment. The goal is to see if DBT improves emoti…

This study tests whether using virtual reality (VR) with calming scripts can reduce anxiety and pain during wisdom tooth extraction. Sixty adults aged 18-65 who need at least two lower wisdom teeth removed will either get standard local anesthesia alone or local anesthesia plus V…

This study tests a special type of melatonin (a natural sleep hormone) in 120 children and teens aged 2-17 with PTSD who have serious sleep issues like trouble falling asleep, waking up often, or nightmares. The goal is to see if this treatment improves sleep time and quality, an…

This study tests whether a personalized version of metacognitive training (P-MCT) works better than the standard version for people with schizophrenia. About 51 adults will receive either standard or personalized training, which uses machine learning to target each person's speci…

This study explores whether interactive virtual reality (VR) can help reduce pain, anxiety, and fatigue in people receiving palliative care. Twenty hospitalized adults will use a VR program that lets them interact with a calming natural environment, aiming to distract the brain f…

This study aims to better understand certain immune cells (B cells) that mistakenly attack the body in autoimmune diseases like lupus and scleroderma. Researchers will analyze blood samples from 200 adults with these conditions or with immune deficiencies. The goal is to identify…

This study tests whether 3D models made from a standard CT scan (no contrast dye) are as accurate as contrast-enhanced CT scans for planning lung cancer surgery. About 50 adults with early-stage lung cancer will have both scans, and doctors will compare the 3D model's predictions…

This study will follow 100 intensive care patients on ECMO, a machine that helps the heart and lungs. The goal is to see if changes in a blood marker called D-dimer can warn doctors about serious bleeding within the next 24 hours. Researchers hope to find a clear threshold to imp…

This study looks at how parents react emotionally after their baby is screened for spinal muscular atrophy (SMA) through a national program in France. Researchers will interview 36 parents and ask them to complete questionnaires about anxiety, depression, and stress. The goal is …

This study tests whether personalized follow-up using patient-reported outcome measures (PROMs) can improve recovery for adults undergoing complex surgery. Researchers will track 276 participants' recovery scores before and after surgery, comparing those who receive standard care…

This study looks at how fatigue affects walking and balance in people with Charcot-Marie-Tooth type 1A (CMT1A), a common inherited nerve disorder. Researchers will compare 44 participants (22 with CMT1A and 22 healthy volunteers) using muscle tests, brain stimulation, and movemen…

This study will check if a protein called the GLP-1 receptor is more active in the blood cells of people with severe leg artery disease compared to those with milder symptoms. Researchers will take one extra blood sample from 50 adults during a routine visit. The goal is to learn…

This study looks at whether using smaller amounts of contrast dye during brain X-rays can still produce clear images for checking unruptured aneurysms. About 244 adults scheduled for routine brain angiography will be randomly assigned to receive either the standard dye amount or …

This study looks at how non-invasive brain stimulation (rTMS) affects two different areas of the cerebellum—one linked to movement and one linked to thinking. Forty healthy adults will receive either stimulating, inhibiting, or fake (placebo) stimulation in random order. The goal…

This study looks at how emotions change throughout the menstrual cycle in autistic women. Researchers will compare them to women with borderline personality disorder, premenstrual dysphoric disorder, and those without any condition. The goal is to better understand emotional ups …

This study looks at how blood clots break down in cancer patients who also have blood clotting issues. Researchers will measure a substance called plasminogen in 150 adults with blood cancers, solid tumors, or septic shock. The goal is to find early warning signs of bleeding or o…

This study enrolls 20 children with severe epilepsy whose standard genetic tests came back negative. Researchers will use a newer technology called long-read genome sequencing to look for complex DNA changes that older methods miss. The goal is to find the genetic cause, which co…