University Hospital, Strasbourg, France

This early-stage trial tested a combination of two drugs—rapamycin and irinotecan—in 42 children and young adults (ages 1–21) with solid tumors that did not respond to standard treatments. The main goal was to find the safest dose and understand side effects. The approach aims to…

This study tested a new approach for stage IIIB/C melanoma, the deadliest form of skin cancer. Nineteen participants received a single infusion of the immunotherapy drug nivolumab, followed by cryotherapy (freezing) of a cancerous lymph node, and then an injection of another immu…

This study tested whether switching from one immunosuppressant to everolimus, along with lowering overall immunosuppression, helps clear BK virus better than just lowering immunosuppression alone. The trial involved 130 kidney transplant recipients with BK virus in their blood. T…

This study tests whether a special donor plasma product called OctaplasLG can help people with septic shock who develop blood clotting problems. Sixty participants will receive either OctaplasLG or a placebo (salt water) to see if the treatment improves clotting and outcomes. The…

This study tested whether using ideal body weight (instead of total body weight) to calculate heparin doses during heart-lung bypass reduces excessive bleeding in obese patients. Sixty obese adults scheduled for heart surgery were randomly assigned to receive heparin based on eit…

This study tested whether pimavanserin, a drug already approved for hallucinations in Parkinson's, can reduce impulse control disorders like compulsive gambling, shopping, or eating. 117 people with Parkinson's and moderate-to-severe impulse control problems took either pimavanse…

This study tested whether adding vildagliptin (a diabetes pill) to insulin helps control blood sugar in people with type 2 diabetes who are on hemodialysis. 70 patients were randomly assigned to receive either insulin alone or insulin plus vildagliptin for 12 weeks. The goal was …

This study tested a freezing technique called cryoablation on 50 adults with desmoid tumors that had grown despite medical treatment. The goal was to stop tumor growth and ease symptoms without surgery. Researchers used MRI to guide the freezing and check results one year later.

This study tested whether tocilizumab, a drug that blocks inflammation, can help people with primary Sjögren's syndrome—an autoimmune disease causing dry eyes, dry mouth, pain, and fatigue. Researchers gave 110 participants either tocilizumab or a placebo to see if it could reduc…

This study looked at 300 adults with active rheumatoid arthritis whose first anti-TNF treatment stopped working. Researchers compared two strategies: switching to a different type of biologic drug or trying a second anti-TNF. The goal was to see which approach better controls the…

This study tested a light-activated treatment called Fotosan®630 for severe gum disease (periodontitis). The goal was to see if it could reduce deep gum pockets and infection better than standard care. The trial involved 36 adults with severe chronic periodontitis and followed th…

This study tested a new way to treat early-stage prostate cancer using MRI-guided ultrasound waves to destroy tumors without surgery. 25 men with low-to-intermediate risk prostate cancer received the treatment. The main goal was to see if no significant cancer remained one year l…

This study tested whether acupuncture can help turn a breech baby (feet or bottom first) into the head-down position before birth. 259 pregnant women with a breech baby at 32-34 weeks received either real acupuncture at a specific point or a sham version. The main goal was to see…

This Phase 2 trial tested a new porous titanium implant to rebuild the front part of the jaw after it is removed during cancer surgery. The implant is designed to avoid the need for bone grafts taken from elsewhere in the body, which can cause additional pain and complications. S…

This early-phase study tested a special artificial larynx with valves in 10 adults who had severe swallowing troubles, often after throat cancer. The goal was to see if the device could help them swallow safely and possibly allow them to close their tracheotomy tube. The study fo…

This study tested whether taking L-arginine, a natural amino acid, for six weeks could improve exercise ability and kidney function in heart transplant recipients. Thirty stable male patients took the supplement twice daily. The goal was to see if it helps with common post-transp…

This study tested a new handheld gamma camera (CarolIReS) in 110 breast cancer patients to see if it could find sentinel lymph nodes that standard methods miss. The camera was used before and during surgery to guide removal and check if any nodes were left behind. The goal was to…

This study tested a new diagnostic method (mass spectrometry) to detect Lyme disease bacteria in skin biopsies from 84 people with early Lyme rash (erythema migrans). The new method was compared to standard PCR and culture tests. The goal was to see if the new technique could ide…

This study tested whether giving intravenous immunoglobulins (IVIG) could prevent BK virus infection in kidney transplant recipients. The virus often causes graft problems. Researchers enrolled 359 patients with low antibody levels against their donor's virus strain and gave some…

This study compared two groups of women having planned C-sections: one group had the surgery at 38 weeks after receiving two steroid shots (betamethasone) to speed up the baby's lung development, while the other group had the surgery at 39 weeks without steroids. The goal was to …

This study tested whether a special germ-trapping dressing (Sorbact) helps wounds heal faster after surgery for pilonidal sinus, a painful condition near the tailbone. About 250 adults took part, and researchers compared Sorbact to a standard dressing over 75 days. The goal was t…

This study tested an online cognitive behavioral therapy (CBT) program designed to reduce stress and prevent mental health problems in health workers caring for COVID-19 patients. 156 healthcare workers participated, receiving either the online CBT or a bibliotherapy program. The…

This study tested whether a 5-month program of dialectical behavior therapy (DBT) can help adults with autism who struggle with self-harm or suicidal thoughts. Researchers enrolled 92 adults with autism and no intellectual disability. The goal was to see if DBT reduces emotional …

This study tested four different ways of conditioning the carbon dioxide gas used during laparoscopic (keyhole) womb surgery. The goal was to see if warming, wetting, or adding a numbing medicine to the gas could prevent a drop in body temperature (hypothermia) and reduce pain af…

This study tested two levels of lumbar traction (a procedure where the lower back is gently stretched) in 17 people with acute sciatica caused by a herniated disc. The goal was to see if higher pulling force reduces leg pain and improves movement better than lower force. Particip…

This study looked at whether laparoscopic promontofixation, a common surgery for pelvic organ prolapse, can be safely performed as an outpatient procedure. Sixty women who needed the surgery were discharged 8 hours after the operation. The main goal was to see how many needed to …

This study tested a new device called a hysteroscopic morcellator against the standard resectoscope for removing uterine polyps. The goal was to see which method is faster and safer. The trial involved 90 adults with a single polyp. The morcellator uses suction and mechanical cut…

This study looked at a different way to manage pain after chest surgery (thoracotomy) for people who cannot get an epidural. A thin tube placed by the surgeon near the wound delivered either a numbing medicine (ropivacaine) or a saltwater placebo for 48 hours. All participants al…

This study looked at whether adding a mindfulness-based stress reduction program to an 8-week exercise plan could improve fitness and quality of life in women with breast cancer. 100 women who had finished chemotherapy and were undergoing radiotherapy or hormone therapy took part…

This study tested whether flushing follicles with a special needle during egg retrieval helps women who produce few eggs in IVF. 257 women with fewer than 5 mature follicles were randomly assigned to standard aspiration or aspiration plus flushing. The goal was to see if flushing…

This study tested a pain relief method for people having chest surgery who cannot get an epidural. Instead, surgeons placed a small tube near the spine to deliver the numbing drug ropivacaine for 48 hours. All patients also received morphine through a pump they control themselves…

This study tested a connected biofeedback probe called EMY, which women use at home with a mobile app to train their pelvic floor muscles. The goal was to see if it improves quality of life for women with stress urinary incontinence—leaking urine when coughing, sneezing, or exerc…

This study looked at 88 people aged 11 or older who finished braces and got a permanent wire glued behind their lower front teeth to keep them straight. Researchers compared two ways of preparing the teeth before gluing: sandblasting the enamel versus cleaning with pumice. The go…

This study explored sleep disorders in 37 adults with non-small cell lung cancer. Participants filled out questionnaires about their sleep, symptoms, mood, and quality of life. The goal was to create a guide to help doctors diagnose and treat sleep issues in this group, ultimatel…

This study investigates whether chronic cannabis use impairs contrast sensitivity — the ability to see objects clearly against their background, especially when they are moving. Researchers will compare three groups: cannabis addicts, tobacco-only smokers, and non-smokers. Partic…

This study looked at the genes inside B cells from 30 people with inactive lupus and compared them to healthy donors. The goal was to find what makes lupus B cells different, even when the disease is quiet. No treatment was given; this is a pure research study to better understan…

This study tested a combination of two methods—radioactive isotope and blue dye injection—to locate sentinel lymph nodes in 100 breast cancer patients. The goal was to see if using both together improves accuracy and cost-effectiveness. Researchers compared the results and analyz…

This study looked at 10 people with liver cancer (HCC) who were getting a standard treatment called chemoembolization (c-TACE). The goal was to see if mixing the chemotherapy drug doxorubicin with salt water or a contrast dye changes how the drug spreads inside the tumor. Researc…

This pilot study tested a smartphone-based decision support system designed to help patients manage medications that are taken only when needed after surgery. The study involved 37 adults who had surgery at a French hospital. Researchers compared the app's recommendations to thos…

This study looked at 300 adults having outpatient surgery to see how often a condition called akathisia (a feeling of severe restlessness) occurs with two different anti-nausea drugs: Droperidol and Ondansetron. The goal was to find out if Droperidol causes more akathisia than On…

This study looked at how small molecules called microRNAs change during pregnancy in women with rheumatoid arthritis or lupus. Researchers collected blood and urine samples before and after pregnancy from 50 women to see if these changes relate to disease activity. The goal is to…

This study collected information from nearly 1,000 people in France with inherited retinal diseases (IRDs) to better understand the genetics behind these conditions. Researchers looked at genetic test results and disease types to help build a national registry. The goal is to imp…

This study looked at how the body naturally stops allergic inflammation after being exposed to grass pollen. Researchers measured specific molecules in the nose that help control and resolve the allergic response. Twenty adults with grass pollen allergies participated. The goal w…

This study looked at whether a family of proteins called GPCRs, found on the surface of cells, can be used as biomarkers to diagnose or track chronic lung diseases like asthma and COPD. Researchers analyzed blood samples from 205 people (healthy volunteers and patients) to see if…

This study looked at how many hospital workers in Strasbourg, France, had antibodies against the virus that causes COVID-19. About 1,466 staff members were tested to see if they had been infected, especially after a large outbreak linked to a religious event. The goal was to unde…

This study looked at how moving your head backward or turning it side to side changes the pressure under your feet while standing. Researchers measured foot pressure in 87 healthy adults aged 18 to 30 using a special platform. The goal was to understand the link between head alig…

This study looked at whether training with an augmented reality simulator helps medical students perform lumbar punctures (spinal taps) better than standard teaching. Lumbar punctures can be stressful for both patients and doctors. The simulator uses haptic feedback to mimic the …

This study looked at 27 adults with a severe form of primary immunodeficiency, which causes frequent infections, enlarged lymph nodes, and low white blood cells. Researchers analyzed their DNA to find known and new genetic mutations linked to the condition. The goal was to better…

This study aims to establish normal values for nerve fiber density in the skin using small biopsies from 300 healthy adults aged 20-80. By comparing results across age and sex, researchers hope to improve the accuracy of diagnosing small fiber neuropathy, a condition that affects…

This study looked at 82 adults infected with Staphylococcus lugdunensis bacteria to find which toxins (harmful substances) the bacteria produce that lead to serious illnesses like blood infections or heart valve infections. Researchers compared samples from patients with differen…

This study aims to establish normal values for a breathing test called the interrupter technique in healthy adults. The test requires very little cooperation from the patient, making it ideal for people who have difficulty performing standard lung function tests. Researchers meas…

This study looked at how the heart and lungs of 10 people with moderate COPD respond to a 30-minute exercise test with short, intense work periods. Researchers measured blood pressure in the lungs and overall heart function. They found that lung blood pressure did not spike dange…

This study looked at whether a simple blood test can monitor lung cancer progression without needing to sample the tumor directly. Researchers checked for genetic changes in the blood of 200 lung cancer patients. The goal was to see if this non-invasive method could track how the…

This study looked at whether a memory technique called 'retrieval practice' works in people with schizophrenia. Participants studied word pairs and were later tested or re-studied them. The goal was to see if testing improves recall more than re-studying. 40 people took part, inc…

This study tested whether exposure to special light lamps at 5am could help people stay alert and think clearly after a full night without sleep. Researchers compared two different light devices to no light at all in 18 healthy adults. The goal was to see if light could reduce fa…

This study looked at how deaf people who were born deaf process reading in their brains. Researchers used brain scans to compare deaf and hearing readers. The goal was to understand how the brain adapts to reading without ever hearing speech sounds. 60 adults who are deaf and hav…

This study tested a new ultrasound fusion system that combines ultrasound with CT scan data to guide needle placement in tissue lesions. Researchers compared the needle path shown by the system to the actual path on a CT scan in 25 patients. The goal was to see if this technology…

This completed study looked at 500 patients who had abdominal wall prosthesis infections after hernia surgery. Researchers aimed to identify risk factors, common germs, and what helps patients recover. The goal is to improve how these infections are managed.

This study looked at how different times of light exposure affect sleep, brain waves, and thinking skills in 92 healthy adults aged 18 to 40. Participants were exposed to white light for 2.5 hours at various times of day. The goal was to understand light's influence on sleep qual…

This study looked at a newer way to take prostate tissue samples using MRI guidance through the perineum (the area between the scrotum and anus) instead of the standard method through the rectum. The goal was to see if this approach causes fewer complications and hospital readmis…

This study looked at how people with schizophrenia organize memories of events. Participants took a 1-hour walk in Strasbourg while wearing an automatic camera. Later, they were asked to put photos from the walk in order and identify where events started and ended. The goal was t…

This study looked at how autism affects personal identity in adults without intellectual disability. Researchers compared 102 autistic adults to healthy controls using memory tests and questionnaires about self-concept. The goal was to understand how autism influences the way peo…

This study looked at how the brain creates the feeling of being in control of our own actions. Researchers compared healthy volunteers with people who have schizophrenia or bipolar disorder, especially those who feel their actions are controlled by an outside force. The goal was …

This study looked at how a two-month exercise program changes the way the body processes different types of dietary fats in men with obesity. Twelve men aged 18 to 55 who were overweight but not extremely obese took part. Researchers measured fat oxidation and gene expression in …

This study followed 77 patients under 60 who had a mechanical aortic valve replacement to see if a mismatch between the valve size and the patient's body affects heart recovery and exercise ability. Participants did exercise tests and heart ultrasounds years after surgery. The go…

This study looked at how people with dementia with Lewy bodies experience their sense of self, including memory and self-concept. Researchers compared 61 participants with dementia, Alzheimer's, and healthy aging using memory tests and brain scans. The goal was to understand whic…

This study looked at how well-trained runners' hearts and lungs respond when running on a treadmill at different slopes: uphill, flat, and downhill. Eight athletes completed tests to measure their peak oxygen uptake and muscle fatigue. The goal was to see if downhill running uses…

This completed study gave 22 healthy volunteers a single dose of diazepam, lorazepam, or a placebo, then used brain scans to see how these drugs affect memory and perception. The goal was to understand why lorazepam may impair unconscious memory more than diazepam. The findings c…

This study looked at whether using custom-made cutting guides, designed from a patient's CT scan, can help place a total knee replacement more accurately. The goal is to reduce the number of patients (up to 30%) who are unhappy with their new knee. Researchers reviewed 20 patient…

This study looked at whether carefully selecting patients for a single surgery (one-step replacement) can effectively treat an infected knee replacement. Researchers reviewed records of 60 patients who had this procedure between 2000 and 2010. The goal was to see if using specifi…

This completed study followed 300 patients with venous thromboembolism (blood clots in veins) to track how often clots return or cause bleeding. Researchers hope to find new risk factors and compare newer blood thinners. The study only observes, so it cannot test treatments direc…

This study looked at 80 patients who had surgery for an infected hip or knee replacement. The goal was to see if giving antibiotics before taking tissue samples during surgery affects the ability to detect the infection. Researchers compared results from patients who received ant…

This study tested whether measuring lactate from a finger-prick (capillary blood) can help doctors identify sepsis patients who need intensive care. Researchers enrolled 60 adults with signs of sepsis outside the ICU. The goal was to see if this quick, bedside test could catch ea…

This study looks at how a standard breathing technique (alveolar recruitment maneuver) affects the heart and lungs during major spine surgery. Researchers compare the effects when patients are lying face-up versus face-down. The goal is to understand differences so doctors can be…

This study looked at how doctors at Strasbourg University Hospital treat shoulder dislocations in the emergency room. The goal was to find ways to reduce pain during the procedure and create a standard care plan. Researchers reviewed the records of 238 adult patients to see what …

This study tested a noninvasive navigation system that measures how the knee moves before surgery. The goal is to see if this information can help surgeons choose or place knee implants more accurately. 40 adults with end-stage knee osteoarthritis who were scheduled for knee repl…