University Hospital, Strasbourg, France

This study tested a two-part treatment for advanced melanoma that had spread to nearby lymph nodes. Doctors first used a freezing technique (cryotherapy) to destroy a specific tumor, injecting an immunotherapy drug directly into it. Patients then received a standard immunotherapy…

This study compared two surgical tools used to remove uterine polyps (non-cancerous growths) during a procedure called hysteroscopy. Researchers tested a newer tool called a morcellator against the standard resectoscope in 90 patients. They wanted to see which tool was faster and…

This study looked at whether giving a standard preventive antibiotic dose before surgery, instead of after taking tissue samples, affects the treatment of infected hip or knee replacements. It involved 80 patients who had surgery to replace an infected joint. The goal was to see …

This study tested if sandblasting teeth before gluing on a permanent lower retainer makes it come loose less often than the standard cleaning method. It involved 88 people in France, aged 11 and older, who had just finished braces. The goal was to find a more reliable way to keep…

This study looked at what to do when the first biologic treatment for rheumatoid arthritis stops working effectively. Researchers compared two approaches: switching to a different drug in the same class versus trying a completely different type of biologic medication. The trial i…

This study tested a new combination of two existing drugs, rapamycin and irinotecan, in children and young adults whose solid tumors did not respond to standard treatments. The main goal was to find the highest dose of this combination that could be given safely. Researchers also…

This study tested whether adding a special light-activated treatment (Fotosan®630) to standard care helps people with severe, ongoing gum disease. It involved 36 adults with significant gum damage to see if this approach improved gum health over six months. The goal was to find o…

This study tested whether a common surgical procedure for pelvic organ prolapse could be safely performed as outpatient surgery, allowing patients to go home the same day. Researchers followed 60 women to see if this approach led to more hospital readmissions or complications whi…

This study tested whether custom-made 3D-printed surgical guides help surgeons position knee replacement implants more accurately. Researchers compared these personalized guides against standard surgical techniques in 20 patients with severe knee arthritis. The goal was to see if…

This study tested whether flushing follicles (small fluid-filled sacs in the ovaries that contain eggs) during egg retrieval helps women who typically produce few eggs for IVF. Researchers compared two egg collection methods—one with standard suction and one with suction plus flu…

This study tested if switching to a different immune-suppressing drug (everolimus) helps kidney transplant patients clear a common and dangerous virus (BK virus) from their blood. It compared this switch to the standard approach of just lowering their current immune-suppressing d…

This study tested whether adding the medication vildagliptin to insulin therapy improves blood sugar control in people with type 2 diabetes who are on dialysis. It involved 70 participants who were monitored for 12 weeks using continuous glucose monitors to track their sugar leve…

This study tested whether a special, standardized plasma product (OctaplasLG®) could help control dangerous blood clotting problems in patients with septic shock. It compared the plasma treatment to a saline placebo in 60 critically ill adults. The main goal was to see if it was …

This study tested whether pimavanserin, a medication already approved for Parkinson's psychosis, could help control impulse control disorders in people with Parkinson's disease. These disorders can cause harmful compulsive behaviors like gambling, binge eating, or hypersexuality.…

This study tested a porous titanium implant to rebuild the front jaw and surrounding soft tissue after surgery. It aimed to provide an alternative to more complex reconstructions using bone flaps from other parts of the body, which often have higher complication rates. The trial …

This study tested whether acupuncture can help turn breech-positioned babies to head-down before delivery. Researchers enrolled 259 pregnant women at 32-34 weeks whose babies were in breech position. They compared real acupuncture at a specific point to sham acupuncture at a diff…

This study tested a procedure called cryoablation, which freezes tumors, for people with painful desmoid tumors that kept growing despite trying at least two standard medications. The goal was to see if freezing the tumor could stop its growth, relieve pain, and improve quality o…

This study tested a new way to calculate the dose of the blood-thinner heparin for obese patients during heart surgery using a heart-lung machine. Researchers compared dosing based on a patient's ideal body weight versus their total weight to see if it prevented excessive blood t…

This study tested if a special wound dressing called Sorbact helps surgical wounds heal faster than a standard dressing after surgery for a pilonidal sinus. Researchers enrolled 251 adults who had the surgery and tracked their healing for 75 days. The main goal was to see if more…

This study looked at whether carefully selecting patients helps heal infections after knee replacement surgery when using a single-surgery approach instead of the standard two-surgeries. Researchers examined 60 adults who had their infected knee implants replaced in one surgery b…

This study tested whether a drug called tocilizumab could help control the disease activity of primary Sjögren's syndrome, an autoimmune condition that causes severe dryness, pain, and fatigue. It involved 110 adults with moderate-to-severe disease activity. Participants were ran…

This study tested whether using MRI to guide focused ultrasound waves could safely destroy prostate cancer tumors. It involved 25 men with early-stage prostate cancer who received this targeted treatment. Researchers checked one year later to see if the cancer was gone and monito…

This study tested a two-part method to help surgeons more accurately find the 'sentinel' lymph nodes—the first places breast cancer is likely to spread. It involved 100 patients with breast cancer and compared using a radioactive tracer with a blue dye during surgery. The goal wa…

This study tested a new lab method to detect Lyme disease from a small skin sample. Researchers compared this new method to two older tests to see if it was better at finding the bacteria that causes Lyme. The goal was to improve early diagnosis when the telltale 'bullseye' rash …

This study compared two different methods of performing prostate biopsies guided by MRI imaging. Researchers wanted to see if a new approach through the perineum (skin between scrotum and anus) causes fewer complications and hospital readmissions than the standard approach throug…

This study tested whether combining ultrasound with CT scan data could help doctors place needles more accurately during procedures like biopsies or injections. Researchers compared the computer-predicted needle path with the actual path seen on a follow-up CT scan in 25 patients…

This study tested a new handheld gamma camera called CarolIReS, used during surgery to help surgeons find and remove the first lymph nodes where breast cancer might spread. It involved 110 patients with early-stage breast cancer. The goal was to see if this camera could improve t…

This study tested whether a simple, quick finger-prick test to measure lactate (a marker of stress in the body) could help doctors identify sepsis earlier in patients outside the intensive care unit. It involved 60 adult patients showing signs of possible infection. The goal was …

This study looked at whether scheduling planned C-sections at 38 weeks of pregnancy, after giving the mother steroid shots, could help prevent breathing problems in newborns. It also aimed to see if this timing could avoid emergency C-sections that happen if labor starts before t…

This early-stage study tested a new type of artificial larynx—a small valve prosthesis placed in the throat. The goal was to see if it could help people with severe swallowing disorders, often caused by throat cancer or surgery, swallow more safely and effectively. Researchers en…

This study tested a connected biofeedback device called EMY to help women manage stress urinary incontinence after childbirth. Fifty-five women who had given birth at least six months earlier used the device to strengthen their pelvic floor muscles. Researchers tracked how well p…

This study tested whether a local anesthetic delivered through a small catheter placed directly in the surgical wound could effectively control pain after major chest surgery. It focused on patients who could not safely receive the standard epidural pain relief method due to medi…

This study compared two common anti-nausea medications given during outpatient surgery to see which one causes fewer cases of akathisia—an uncomfortable feeling of restlessness. Researchers followed 300 adults at risk for post-surgery nausea to track who developed this side effec…

This study tested whether using a stronger pulling force during lumbar traction treatment works better than a gentler force for reducing leg pain from acute sciatica caused by a slipped disc. Researchers compared the two approaches in 17 patients with recent sciatica symptoms. Th…

This study tested whether an online therapy program could help reduce stress and prevent mental health problems in healthcare workers caring for COVID-19 patients. 156 French healthcare workers participated, with some receiving the online Cognitive Behavioral Therapy (CBT) progra…

This study tested an alternative pain control method for patients who cannot receive the standard epidural pain relief after chest surgery. Researchers compared a local anesthetic delivered through a small catheter placed near the spine against a placebo, with both groups also ha…

This study tested whether combining an 8-week mindfulness meditation program with endurance exercise could help women recovering from breast cancer. It involved 100 women who had finished chemotherapy and were undergoing other treatments. Researchers measured whether this combine…

This study tested whether a 5-month therapy program could help autistic adults who do not have an intellectual disability. The therapy, called Dialectical Behavior Therapy (DBT), was given to 92 participants to see if it could improve their ability to manage difficult emotions an…

This study tested whether warming and wetting the carbon dioxide gas used to inflate the abdomen during keyhole womb surgery could help prevent patients from getting too cold during the operation. It also tested if adding a local painkiller to this gas could reduce pain after sur…

This study tested whether taking L-arginine, a dietary supplement, for six weeks could improve exercise capacity and kidney function in stable male heart transplant recipients. Researchers wanted to see if this supplement could help with common issues like reduced exercise abilit…

This study looked back at how a hospital emergency department treated patients with dislocated shoulders. Researchers reviewed the care given to 238 adult patients to find ways to standardize treatment and, most importantly, reduce the pain people feel when their shoulder is put …

This study tested a new, non-invasive system to measure how the knee moves in patients with severe osteoarthritis. Researchers enrolled 40 adults scheduled for knee replacement surgery to see if measuring natural knee motion before the operation could help surgeons choose or posi…

This study aimed to understand how running on different slopes affects athletes' bodies. Researchers measured oxygen use and muscle fatigue in 8 well-trained runners as they ran uphill, downhill, and on flat treadmills. The goal was to compare how the body responds to these diffe…

This study looked at whether having a slightly mismatched aortic valve after replacement surgery affects long-term heart function and exercise ability. Researchers followed 77 patients under age 60 who received mechanical aortic valve replacements to measure their exercise capaci…

This study aimed to understand how regular exercise changes where the body sends different types of dietary fat—toward muscle to be burned or toward fat tissue for storage—in inactive men with obesity. Researchers studied 12 participants before and after two months of exercise tr…

This study aimed to establish normal ranges for tiny nerve fibers in the skin across different ages and sexes. Researchers collected small skin samples from 300 healthy volunteers to measure nerve fiber density. The results will help doctors better diagnose small fiber neuropathy…

This study tested whether training medical students with a new augmented reality simulator improves their success rate when performing their first real lumbar puncture (spinal tap) on a patient. Sixty patients requiring the procedure as part of their care participated. Researcher…

This study aimed to understand why some people with schizophrenia or bipolar disorder feel their own actions are controlled by an outside force. Researchers compared healthy volunteers with patients who had these conditions. They tested how people process the sensory results of t…

This study aimed to understand how dementia with Lewy bodies affects a person's sense of self, including their personal memories and self-concept. Researchers compared 61 older adults with Lewy body dementia, Alzheimer's disease, or healthy aging using brain scans and memory test…

This study measured COVID-19 antibodies in 1,466 hospital staff members after a major outbreak at their workplace. Researchers wanted to understand how many workers had been infected, including those who showed no symptoms. They tracked antibody levels over one year to see how lo…

This small pilot study tested whether a new smartphone app could help patients after surgery. The app was designed to help patients communicate with nurses about their medication needs. Researchers wanted to see if using the app was practical and if it could help patients get the…

This study aimed to understand how the body naturally turns off allergic inflammation after exposure to grass pollen. Researchers tracked 20 people with grass pollen allergies, measuring specific fat molecules in their nasal fluids after a controlled allergen challenge. The goal …

This study aimed to understand why the bacteria Staphylococcus lugdunensis causes severe infections like bloodstream infections and heart infections in some people. Researchers compared 82 adult patients with different types of infections to see if specific bacterial toxins were …

This study created a registry to follow 300 patients recently diagnosed with serious blood clots (venous thromboembolism or VTE). The goal was to better understand why these clots happen, track how often they come back, and compare the safety and effectiveness of newer blood-thin…

This study tested whether a learning method called 'retrieval practice' works for people with schizophrenia. Researchers compared 40 people (some with schizophrenia, some without) to see if practicing recalling word pairs from memory helps long-term learning more than just re-stu…

This study aimed to understand how a special breathing technique used during surgery affects patients' lungs and blood flow when they are lying on their back versus their stomach. Researchers observed 30 adults undergoing major spine surgery to compare the effects. The goal was t…

This study looked back at 500 patients who had a surgical mesh placed to repair a hernia. The goal was to understand why infections sometimes happen after this surgery, what types of infections occur, and what factors help patients recover. The researchers analyzed patient record…

This study aimed to establish normal breathing resistance values in healthy adults using a simple technique that requires minimal patient cooperation. Researchers measured 122 healthy, non-smoking adults to create reference ranges for this breathing test. The results will help do…

This study aimed to understand how people with schizophrenia organize memories of personal events in time. 80 participants, including patients and healthy volunteers, took a one-hour walk wearing an automatic camera. Later, researchers tested their ability to put photos from the …

This study aimed to better understand how the heart and lungs of people with chronic obstructive pulmonary disease (COPD) work during a specific 30-minute exercise test. Researchers observed 10 patients with moderate COPD while they performed an exercise routine with intense burs…

This study aimed to understand how different types of light exposure affect feelings of tiredness and mental performance after a night without sleep. Researchers tested 18 healthy young adults to see if light could help counteract the effects of sleep loss. The goal was to gather…

This study aimed to understand how the position of your head affects pressure distribution under your feet while standing. Researchers measured foot pressure in 87 healthy young adults while they held their heads in different positions. The goal was to gather basic knowledge abou…

This study aimed to understand how different types of light exposure affect sleep quality and how alert and focused people feel the next day. Researchers monitored 92 healthy young adults, measuring their brain waves during sleep and testing their attention and thinking skills af…

This completed study aimed to understand how immune cells called B lymphocytes differ in people with inactive systemic lupus erythematosus compared to healthy people. Researchers analyzed the gene activity profiles of these purified cells from 30 participants. The goal was to ide…

This study aimed to understand how autism spectrum disorder affects a person's sense of self and identity in adulthood. Researchers compared 102 adults with autism (without intellectual disability) to neurotypical adults by asking them to share and describe personal memories and …

This study aimed to gather information about inherited retinal diseases (IRDs) in France. Researchers collected genetic and health data from 998 patients of all ages to understand how these diseases vary and which genetic changes cause them. The goal was to create a national pati…

This study aimed to understand how two common anxiety medications (diazepam and lorazepam) affect brain activity during different types of memory tasks. Researchers gave single doses to 22 healthy young volunteers and used brain scans (fMRI) to see how the drugs changed brain pat…

This study aimed to understand how the brains of people born deaf process reading compared to hearing people. Researchers used brain scans (fMRI) on 60 deaf and hearing adults to see if the brain areas used for reading are different. The goal was to learn more about how hearing l…

This study aimed to understand why rheumatoid arthritis symptoms often improve during pregnancy while lupus symptoms may get worse. Researchers followed 50 pregnant women with either condition to analyze tiny molecules in their blood and tissues. The goal was to find clues that c…

This study aimed to understand the genetic causes of a severe form of primary immunodeficiency in adults. Researchers analyzed the genes and immune cells of 27 participants who had the condition along with specific complications. The goal was to find known or new genetic mutation…

This study aimed to discover new biological markers in the blood that could help doctors better diagnose and monitor two common lung diseases: asthma and COPD. Researchers analyzed blood samples from 205 people, including healthy volunteers and patients with these conditions. The…

This study investigated whether a simple blood test could monitor lung cancer progression without needing repeated tumor biopsies. Researchers followed 200 lung cancer patients to see if genetic markers in their blood matched their tumor's genetic changes. The goal was to develop…