University Hospital, Strasbourg, France

This study looked at whether adding the drug vildagliptin to insulin helps control blood sugar in people with type 2 diabetes who are on dialysis. About 70 patients took part. The goal was to see if this combination is safe and effective for this hard-to-treat group.

This study looked at 130 kidney transplant patients with BK virus in their blood. It compared two approaches: reducing standard anti-rejection drugs alone versus reducing them and switching one drug to everolimus. The goal was to see if the switch helps clear the virus better whi…

This study tested whether taking L-arginine supplements for six weeks can improve exercise ability and kidney function in heart transplant recipients. Thirty stable male patients who had received a heart transplant at least six weeks earlier took part. The goal was to see if this…

This study tested a freezing technique called cryoablation on rare, non-cancerous but aggressive desmoid tumors located outside the belly area. The goal was to stop tumor growth and ease pain in 50 adults whose tumors continued to grow after at least two other treatments. Doctors…

This study tested a light-based treatment called FOTOSAN® for severe gum disease (periodontitis). The goal was to see if adding this therapy to standard care helps reduce deep gum pockets and infection. 36 adults with severe gum disease took part, and researchers measured changes…

This early-stage study tested a combination of two drugs, rapamycin and irinotecan, in 42 children and young adults (ages 1-21) with solid tumors that did not respond to standard treatments. The main goal was to find the safest dose and understand side effects. The approach aims …

This study tested whether a special donor plasma product (OctaplasLG) can help correct dangerous blood clotting problems in people with septic shock. The trial included 60 adults with septic shock and clotting issues. Researchers measured how quickly treatment was given and track…

This early-phase study tested a new approach for stage IIIB/C melanoma that has spread to lymph nodes. Doctors used a freezing technique (cryotherapy) to destroy accessible tumors, then injected the immunotherapy drug ipilimumab directly into the treated area, along with a flat d…

This study tested whether sandblasting the teeth before gluing a permanent retainer (a wire behind the lower front teeth) works better than the usual pumice polishing. 88 people aged 11 and older who just finished braces took part. The goal was to see if sandblasting reduces the …

This study tested a new way to treat early-stage prostate cancer using MRI-guided ultrasound waves delivered through the urethra. The goal was to destroy the cancer without surgery or radiation. Twenty-five men with low-to-intermediate risk prostate cancer took part. The main que…

This early study tested a special artificial larynx with valves in 10 adults who had severe swallowing troubles. The goal was to see if the device could help them swallow safely and possibly allow them to close their tracheotomy. The study focused on checking breathing and using …

This study tested a drug called tocilizumab in 110 adults with primary Sjögren's syndrome, an autoimmune disease that causes dry eyes, dry mouth, pain, and fatigue. Tocilizumab blocks a protein (IL-6) that fuels inflammation. The goal was to see if it could reduce disease activit…

This study looked at 300 adults with active rheumatoid arthritis who did not respond well to their first anti-TNF medication. Researchers compared two strategies: switching to a different anti-TNF or changing to a biologic with a different mechanism of action (like abatacept, rit…

This study tested a new way to rebuild the front part of the lower jaw after surgery using a porous titanium implant. The goal was to avoid more complex bone grafts that often cause complications. Seven adults took part, and the implant was designed to be easy and quick to attach…

This study looked at whether a simple finger-prick test to measure lactate levels can help doctors identify patients with severe sepsis early, even before they are in the intensive care unit. The test is fast and easy to do at the bedside. 60 adults with signs of sepsis took part…

This study tested a new handheld gamma camera (CarolIReS) to help surgeons find and remove sentinel lymph nodes in 110 women with early breast cancer. The camera was used before and during surgery to check if any nodes were missed by standard methods. The goal was to see if the c…

This study tested a double method using a radioactive tracer and a blue dye to find the sentinel lymph node in 100 women with infiltrative breast cancer. The goal was to see if using both methods together improves accuracy and is cost-effective. The approach helps doctors know if…

This study looked at 200 women who needed a planned C-section. One group had the surgery at 38 weeks after receiving steroids to help the baby's lungs, while the other group waited until 39 weeks without steroids. The goal was to see if the earlier timing could prevent emergency …

This study tested whether stronger or gentler back stretching (traction) works better for sudden leg pain caused by a slipped disc. Seventeen adults with recent sciatica received either high or low force traction. Researchers measured pain and leg movement to see which force leve…

This study tested a pain-relief method for people recovering from chest surgery (thoracotomy) who cannot have standard epidural pain control. A small tube placed in the wound delivered either a numbing medicine (ropivacaine) or a saltwater placebo for 48 hours. All patients also …

This study tested a connected biofeedback device called EMY to help women with stress urinary incontinence (leaking urine when coughing, sneezing, or exercising). Fifty-five women who had given birth at least six months earlier used the device to train their pelvic floor muscles.…

This study tested an online cognitive behavioral therapy (CBT) program designed to lower stress and prevent mental health problems like depression, anxiety, and insomnia in health workers caring for COVID-19 patients. 156 healthcare workers participated, and the program aimed to …

This study looked at whether flushing the follicles with fluid during egg retrieval helps women who produce few eggs (poor responders) get more eggs for IVF. 257 women with fewer than 5 mature follicles were randomly assigned to standard egg retrieval or retrieval with flushing. …

This study compared a newer device called a hysteroscopic morcellator with a traditional resectoscope for removing uterine polyps in 90 women. The goal was to see which tool works faster and causes fewer complications. The morcellator may offer benefits like smaller size, less ri…

This study tested whether pimavanserin, a drug already approved for Parkinson's psychosis, can reduce impulse control disorders like compulsive gambling or eating in people with Parkinson's disease. 117 adults aged 35-75 with moderate symptoms took part. The goal was to see if th…

This study tested whether a special germ-trapping dressing (Sorbact) helps wounds heal faster after surgery for pilonidal sinus, a painful condition near the tailbone. About 250 adults took part, and researchers compared Sorbact to a standard dressing over 75 days. The goal was t…

This study tested a pain relief method for people having chest surgery who cannot get an epidural. Surgeons placed a small tube near the spine to deliver numbing medicine for 48 hours. All patients also received morphine through a pump. The goal was to see if this approach reduce…

This study tested if acupuncture can help turn breech babies (feet-first) into the head-down position before birth. 259 pregnant women with a breech baby at 32-34 weeks received either real acupuncture or a sham version. The goal was to see if the baby had turned by 35 weeks.

This study tested four ways of conditioning the carbon dioxide gas used during laparoscopic (keyhole) womb surgery. The goal was to see if warming, moistening, or adding numbing medicine to the gas could prevent a drop in body temperature and reduce pain after surgery. 248 women …

This study looked at whether combining an 8-week mindfulness-based stress reduction program with endurance exercise training can help women with breast cancer feel better and improve their physical fitness. Researchers measured changes in exercise capacity, quality of life, and b…

This study looked at how well-trained runners' hearts and lungs respond to running on a treadmill at different slopes—downhill, flat, and uphill. Eight athletes participated to see if downhill running uses less oxygen than flat or uphill running. The goal was to better understand…

This study analyzed the genes of 27 adults with a severe immune disorder called common variable immune deficiency (CVID) who also had low white blood cells (neutropenia) and enlarged lymph nodes. Researchers looked for known and new gene mutations to better understand the disease…

This study looked at how dementia with Lewy bodies (DLB) affects a person's sense of self, including memory and self-concept. Researchers compared 61 older adults with DLB, Alzheimer's disease, and healthy aging using memory tests and brain scans. The goal was to understand brain…

This study looked at whether a family of proteins called GPCRs can be used as biomarkers to diagnose or track chronic lung diseases like asthma and COPD. Researchers analyzed blood samples from 205 participants (healthy people and patients) to find unique GPCR patterns for each d…

This study measured normal breathing resistance in 122 healthy, non-smoking adults using a technique that requires little cooperation. The goal was to establish reference values for adults, similar to those already used in children. This method could help evaluate lung function i…

This study looked at 30 adults having major spine surgery to see how a lung-opening maneuver (called alveolar recruitment) affects breathing and blood flow when done in the prone (face-down) versus supine (face-up) position. The goal was to understand these effects better so doct…

This study aims to establish normal values for nerve fiber density in the skin of healthy adults. By collecting data from 300 participants aged 20 to 80, researchers hope to improve the accuracy of diagnosing small fiber neuropathy, a condition that causes pain and numbness. The …

This study looked at whether training with an augmented reality simulator helps medical students perform their first lumbar puncture (a needle procedure to collect spinal fluid) more successfully. Sixty patients who needed a lumbar puncture took part. The goal was to see if stude…

This study looked at how people with schizophrenia organize memories of everyday events. About 80 participants, including patients and healthy volunteers, took a 1-hour walk in Strasbourg while wearing an automatic camera. Later, they were asked to put photos from the walk in ord…

This study collected information from nearly 1,000 people in France who have inherited retinal diseases (IRDs) — genetic conditions that can cause vision loss. Researchers looked at patients' medical records and genetic test results to better understand which gene changes cause t…

This study looked at 50 pregnant women with rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE) to see if changes in microRNAs (tiny molecules that control genes) during pregnancy are linked to disease activity. Researchers collected blood, urine, and placenta samples…

This study followed 300 people who had a blood clot in a vein (deep vein thrombosis or pulmonary embolism) to better understand the disease. Researchers tracked how often clots came back and how often bleeding complications happened. The goal was to find new risk factors and comp…

This study looked at 80 patients who had surgery for an infected hip or knee replacement. The goal was to see if giving antibiotics before surgery changes the results of infection tests taken during the operation. The researchers compared test results from before and during surge…

This study looked at 82 adults infected with Staphylococcus lugdunensis bacteria to find out which toxins (harmful substances) make some infections severe, like blood infections or heart valve infections. Researchers compared bacteria from patients with different types of infecti…

This study looked at how the brain creates the feeling of being in control of one's own actions. Researchers compared healthy volunteers with people who have schizophrenia or bipolar disorder, especially those who feel their actions are controlled by an outside force. The goal wa…

This study looked at how autism affects a person's sense of self in adulthood. Researchers compared autistic adults (without intellectual disability) to non-autistic adults by asking them to recall personal memories and describe what defines them. The goal was to understand diffe…

This study looked at how many hospital workers in Strasbourg, France, had antibodies against the virus that causes COVID-19. About 1,466 staff members were tested to see if they had been infected and developed immune defenses. The goal was to understand how far the virus spread a…

This study looked at how different light conditions affect sleep, brain activity, and thinking skills in 92 healthy adults aged 18 to 40. Participants were monitored while sleeping and performing attention and memory tasks. The goal was to understand light's influence on the brai…

This study reviewed 60 patients who had a single surgery to replace an infected knee implant. Researchers wanted to see if carefully selecting patients based on factors like age, infection type, and bone health could improve healing. The goal was to find out if this approach work…

This study looked at how different types of light affect tiredness and thinking skills in healthy adults after they stayed awake all night. 18 volunteers aged 18 to 40 were tested. The goal was to learn more about sleep loss, not to provide a treatment.

This study looked at how being born deaf changes the way the brain processes reading. Researchers compared brain scans of 60 deaf and hearing adults while they read. The goal was to understand how the brain adapts when sound is not available for learning to read.

This study looked at whether using custom-made cutting guides, designed from a patient's CT scan, can help surgeons place a total knee replacement more accurately. The goal is to reduce the number of people who are unhappy with their new knee. The study involved 20 adults with en…

This study looked at how two anxiety medications, lorazepam and diazepam, affect memory and brain activity in healthy young adults. Twenty-two volunteers took a single dose of one of the drugs and then performed memory tasks while their brains were scanned with fMRI. The goal was…

This study looked at how moderate physical activity affects the way the body processes different types of dietary fat in men with obesity. Twelve men aged 18 to 55 with a BMI over 25 and a sedentary lifestyle completed two months of exercise training. Researchers used stable isot…

This study tested how accurately an ultrasound fusion system can guide a needle to a target in the body. Researchers compared the planned needle path shown by the system to the actual path seen on a CT scan in 25 adults. The goal was to see if this technology improves precision, …

This study looked at 77 patients under 60 who had a mechanical aortic valve replacement for narrowing. Researchers wanted to see if having a valve that is too small (mismatch) affects exercise ability and heart recovery years later. They measured oxygen use during exercise and he…

This study looked at 300 adults having outpatient surgery to see if the drug Droperidol, used to prevent nausea and vomiting, causes more akathisia (a feeling of inner restlessness and need to move) than another drug called Ondansetron. Participants received either a low or high …

This study looked at whether a simple blood test can detect genetic changes from lung cancer tumors. Researchers tested 200 patients with non-small cell or small cell lung cancer to see if the test could track how the disease changes over time. The goal was to find a less invasiv…

This study looked at B cells (a type of immune cell) in 30 people with non-active systemic lupus erythematosus and compared them to B cells from healthy volunteers. The goal was to find genetic differences that might explain lupus even when symptoms are quiet. No treatment was gi…

This study measured how moving the head forward or backward changes pressure on the feet in 87 healthy adults aged 18-30. Participants stood on a pressure platform while researchers recorded foot pressure. The goal was to understand the link between head alignment and balance, no…

This study tested a smartphone app designed to help patients decide when to take certain medications after surgery. The app gave recommendations based on a medical algorithm, and researchers compared them to advice from a nurse. The goal was to see if the app was practical and re…

This study looked at how 238 adults with a dislocated shoulder were treated in the emergency room at a French hospital. The goal was to find ways to reduce pain during the procedure and create a standard care plan. The research focused on reviewing past practices and medical reco…

This study looked at whether a learning technique called retrieval practice (testing yourself on material) works for people with schizophrenia. 40 participants, including patients and healthy volunteers, studied word pairs and were tested two days later. The goal was to see if te…

This study looked at how the heart and lungs of 10 people with moderate COPD respond during a 30-minute exercise test with short, intense work periods. Researchers found that lung artery pressure dropped after the first 5 minutes and heart output stayed steady, even with high-int…

This study tested a new way to take prostate biopsies using MRI guidance through the perineum (the area between the scrotum and anus) instead of the usual method through the rectum. The goal was to see if this approach causes fewer complications and hospital readmissions, and if …