Freezing tumors to boost immune attack on advanced skin cancer

This study tested a two-part treatment for advanced melanoma that had spread to nearby lymph nodes. Doctors first used a freezing technique (cryotherapy) to destroy a specific tumor, injecting an immunotherapy drug directly into it. Patients then received a standard immunotherapy drug (nivolumab) by infusion. The goal was to see if destroying one tumor this way could help the body's immune system better attack other cancer spots throughout the body.