Can a Parkinson's psychosis drug tame impulse control disorders?
NCT ID NCT03947216
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study tested whether pimavanserin, a drug already approved for hallucinations in Parkinson's, can reduce impulse control disorders like compulsive gambling, shopping, or eating. 117 people with Parkinson's and moderate-to-severe impulse control problems took either pimavanserin or a placebo daily for 8 weeks. The goal was to see if the drug could lessen these behaviors safely.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- pimavanserin (brand name Nuplazid)
- What this could lead to
- If it works, this could offer a new treatment option for impulse control disorders in Parkinson's disease, potentially reducing problematic behaviors without worsening motor symptoms.
- What could go wrong
- This is a small, early-phase (phase 2) study. The results may not confirm effectiveness, and the drug may not work for everyone. Side effects are possible, though pimavanserin has a generally good safety profile.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Centre d'Inverstigation Clinique, CHU de Poitiers
Poitiers, 86021, France
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SERVICE DE NEUROLOGIE C, Unité mouvement anormaux/Centre expert Parkinson, CHU de Lyon, Hopital neurologique Pierre Wertheimer
Bron, 69677, France
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SERVICE DE NEUROLOGIE Centre Expert Parkinson Hopital de la Pitié-Salpêtrière
Paris, 75651, France
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SERVICE DE NEUROLOGIE Unité de Mouvements Anormaux/Centre expert Parkinson, CHU de Strasbourg, Hopital de Hautepierre
Strasbourg, 67098, France
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SERVICE DE NEUROLOGIE, CHU de REIMS
Reims, 51100, France
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SERVICE DE NEUROLOGIE, Unité Mouvement Anormaux/Centre expert Parkinson, CHU de Lille, Hopital Roger Salengro
Lille, 59037, France
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SERVICE DE NEUROLOGIE, Unité Mouvement Anormaux/Centre expert Parkinson, Hopital de la Timone
Marseille, 13385, France
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SERVICE DE NEUROLOGIE, Unité Mouvements Anormaux/Centre expert Parkinson CHU Clermont-Ferrand, Hopital Gabriel Montpied
Clermont-Ferrand, 63003, France
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SERVICE DE NEUROLOGIE, Unité Mouvements Anormaux/Centre expert Parkinson, CHU de Grenoble Alpes
Grenoble, 38043, France
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SERVICE DE NEUROLOGIE, Unité Mouvements Anormaux/Centre expert Parkinson, CHU de Limoges
Limoges, 87042, France
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SERVICE DE NEUROLOGIE, Unité Mouvements Anormaux/Centre expert Parkinson, CHU de Rennes, Hopital Pontchaillou
Rennes, 35033, France
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SERVICE DE NEUROLOGIE, Unité Mouvements Anormaux/Centre expert Parkinson, CHU de Rouen, Hopital Charles Nicolle
Rouen, 76031, France
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SERVICE DE NEUROLOGIE, Unité Mouvements Anormaux/Centre expert Parkinson, CIC, CHU de Nantes, Hopital Laennec
Nantes, 44093, France
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SERVICE DE NEUROLOGIE, Unité Mouvements Anormaux/Centre expert Parkinson, CIC, CHU de Toulouse, Hopital Pierre-Paul Riquet
Toulouse, 31059, France
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SERVICE DE NEUROLOGIE, Unité Mouvements Anormaux/Centre expert Parkinson, Hopital Henri Mondor
Créteil, 94010, France
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Service de Neurologie and CIC -CHU Besançon
Besançon, France
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