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Which biologic works best after Anti-TNF failure? study seeks answers

NCT ID NCT01000441

Completed Disease control Sponsor: University Hospital, Strasbourg, France Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at 300 adults with active rheumatoid arthritis whose first anti-TNF treatment stopped working. Researchers compared two strategies: switching to a different type of biologic drug or trying a second anti-TNF. The goal was to see which approach better controls the disease over 12 months.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

rheumatoid arthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RHEUMATOID ARTHRITIS

Contacts and locations

Locations

  • CH Saint Philibert

    Lomme, France

  • CHRU Lille - Hôpital Salengro

    Lille, France

  • CHU Bordeaux - Hôpital Pellegrin

    Bordeaux, France

  • CHU Chenevier - Mondor

    Paris, France

  • CHU Gabriel Montpied

    Clermont-Ferrand, France

  • CHU Montpellier, Hôpital Lapeyronie

    Montpellier, France

  • CHU de Besançon - Hôpital Jean Minjoz

    Besançon, France

  • CHU de Caen

    Caen, France

  • CHU de Grenoble - Hôpital Sud

    Grenoble, France

  • CHU de Limoges

    Limoges, France

  • CHU de Montpellier - Hôpital Lapeyronie

    Montpellier, France

  • CHU de Nancy - Hôpital Brabois

    Vandœuvre-lès-Nancy, France

  • CHU de Nantes - Hôtel Dieu

    Nantes, France

  • CHU de Nice - Hôpital de l'Archet 1

    Nice, France

  • CHU de Poitiers - Hôpital de la Milétrie

    Poitiers, France

  • CHU de Reims - Hôpital Maison Blanche

    Reims, France

  • CHU de Rennes - Hôpital Sud

    Rennes, France

  • CHU de Rouen - Hôpital Bois Guillaume

    Rouen, France

  • CHU de Saint-Etienne

    Saint-Etienne, France

  • CHU de Toulouse - Hôpital Purpan

    Toulouse, France

  • CHU de la Cavale Blanche

    Brest, France

  • Centre Hospitalier - Princesse Grâce de Monaco

    Monaco, Monaco

  • Centre Hospitalier Départemental Les Oudairies

    La Roche-sur-Yon, France

  • Centre Hospitalier Jean Rougié

    Cahors, France

  • Centre Hospitalier René Dubos

    Pontoise, France

  • Centre Hospitalier Régional d'Orléans, Hôpital de la Source

    Orléans, France

  • Centre Hospitalier de Belfort-Montbéliard

    Belfort, France

  • Centre Hospitalier de Cannes

    Cannes, France

  • Centre Hospitalier de Mulhouse - Hôpital Emile Muller

    Mulhouse, France

  • Centre Hospitalier du Mans

    Le Mans, France

  • Groupe Hospitalier Diaconesses - Hôpital de la Croix Saint-Simon

    Paris, France

  • Groupe Hospitalier du Havre - Hôpital J.Monod

    Le Havre, France

  • Hôpital Ambroise Paré

    Boulogne-Billancourt, France

  • Hôpital Bichat

    Paris, France

  • Hôpital Bicêtre

    Le Kremlin-Bicêtre, France

  • Hôpital Jean Verdier

    Bondy, France

  • Hôpital Lariboisière

    Paris, France

  • Hôpital Saint-Antoine

    Paris, France

  • Hôpital de Hautepierre

    Strasbourg, France

  • Hôpital de la Conception

    Marseille, France

  • Hôpital de la Pitié Salpétrière

    Paris, France

  • Hôpitaux Civils de Colmar

    Colmar, France

  • Polyclinique de Picardie

    Amiens, France

  • Polyclinique de Riaumont

    Liévin, France

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