New spinal fluid test aims to end misdiagnosis of common dementia

NCT ID NCT07166744

First seen Nov 01, 2025 · Last updated Jun 12, 2026 · Updated 34 times

Summary

This study aims to see if measuring a specific form of the protein alpha-synuclein in spinal fluid can reliably distinguish dementia with Lewy bodies (DLB) from Alzheimer's disease. About 286 adults aged 50 and older with signs of either condition will have a lumbar puncture to collect fluid. The goal is to improve diagnosis, since misdiagnosis can lead to dangerous reactions to certain medications in people with DLB.

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