Apple a day keeps the allergy away? new trial tests raw apple therapy

NCT ID NCT06771791

Recruiting now Disease control Sponsor: University Hospital, Strasbourg, France Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether eating small, increasing amounts of raw apple can reduce mouth allergy symptoms in people who are allergic to both birch pollen and apples. 110 participants will eat either real apple or a placebo over 9 months. The goal is to see if they can tolerate a larger dose of apple without symptoms, potentially offering a simple treatment option.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: raw apple
What this could lead to: If it works, this could offer a practical way for people with birch-apple allergy to eat raw apples without mouth itching or swelling, improving their quality of life.
What could go wrong: This is a Phase 3 trial, but the treatment is simply eating apple, so the effect may be modest. Allergic reactions during the test are possible, and results may not apply to all apple varieties or other related fruits.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

allergic disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALLERGIES

Contacts and locations

Locations

Chu Jean Minjoz
NOT_YET_RECRUITING

Besançon, 25030, France
Hopital François Mitterrand Chu Dijon
RECRUITING

Dijon, 21079, France
Hopital Maison Blanche Chu Reims
NOT_YET_RECRUITING

Reims, 51092, France
Hôpitaux Universitaires de Strasbourg
RECRUITING

Strasbourg, France, 67000, France

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