ACUTE RESPIRATORY FAILURE

This study tests whether reducing immunosuppressive drugs (along with giving a steroid) helps kidney transplant patients recover from septic shock or severe breathing failure in the ICU. About 212 adults whose transplant was at least 3 months ago will be randomly assigned to eith…

This study tests a new AI device called EMILY that automatically adjusts oxygen levels for people with acute or chronic respiratory failure. Researchers will enroll 20 adults in the hospital to see how well the device keeps oxygen in a safe range and how quickly it responds to ch…

This study is testing a small device called the MiniLung petite kit, which helps oxygenate blood and remove carbon dioxide in newborns and children weighing 2 to 8 kilograms who have severe breathing or heart failure. The device works with a console to temporarily take over the w…

This study tests whether the sedative dexmedetomidine can help critically ill patients tolerate non-invasive ventilation (a mask that helps breathing) and avoid needing a breathing tube. About 846 adults with acute respiratory failure will receive either the drug or a placebo. Th…

This study is testing a new way to check the health of ICU patients who are on breathing machines. Researchers collect a small sample of the air patients breathe out and analyze its proteins. They also take a blood sample to look for related changes in DNA, RNA, and other molecul…

This study looks at whether a bedside ultrasound of a large vein (the inferior vena cava) can help emergency doctors quickly tell if a patient's breathing trouble is caused by fluid buildup in the lungs from heart failure or from another cause. Researchers will enroll 200 adults …

This pilot study tests a self-management program based on cognitive behavioral therapy to help people who survived acute respiratory failure and now struggle with anxiety. Sixty ICU survivors will either receive the program or usual care. The goal is to see if the program is prac…

This study compares two ways of giving breathing support to adults with acute respiratory failure in the ICU. One group gets standard noninvasive ventilation (a mask that helps breathing), while two other groups get that plus a high-flow nasal cannula (a device that delivers warm…

This study tests whether virtual reality (VR) can help patients in the intensive care unit (ICU) relax, improve their mood, and keep their minds active. Participants will use a VR headset for about 15 to 45 minutes each day for up to 5 days, doing breathing exercises, brain games…

This study tests whether a live video connection between paramedics and pediatric emergency doctors improves care for critically ill children. Paramedics will treat infant mannequins in simulated ambulance scenarios, with some getting video support and others only audio. The goal…

This study tests whether a special imaging technique called electrical impedance tomography (EIT) can safely measure blood flow and air distribution in the lungs of children with acute respiratory failure. Twenty children under 12 who are on breathing machines will receive a smal…

This study looks at whether using an EEG (a device that measures brain activity) can give a more accurate picture of sleep quality in intensive care patients with acute respiratory failure, compared to the usual nurse assessments. About 47 adults in the ICU will have their sleep …

This study compares two methods—waveform capnography and a color-changing carbon dioxide detector—to see which more accurately confirms that a breathing tube is in the right place (the windpipe) in critically ill adults. About 2,000 patients in emergency departments or intensive …

This study looks at how the brain and lungs communicate in patients with severe breathing failure who are getting high-flow oxygen. Researchers will use brain wave monitors (EEG), oxygen sensors (NIRS), and muscle activity sensors (EMG) before and after starting oxygen therapy. T…

This study is collecting data from 250 patients with acute respiratory failure to develop an AI model that groups patients by their characteristics. The goal is to personalize treatment and improve outcomes. It is an observational study, meaning no new drug or device is being tes…

This pilot study tests whether sodium bicarbonate (baking soda) can be used safely as a contrast agent to map lung blood flow using electrical impedance tomography (EIT) in adults on breathing machines. Researchers will compare it to standard hypertonic saline in 41 ICU patients.…

This study looks at whether a special ultrasound technique can help doctors choose the right oxygen flow for patients who have trouble breathing. Researchers will measure how the diaphragm moves in healthy people and in patients with respiratory failure. The goal is to see if thi…

This study looks at how the type of oxygen monitor and the oxygen level target affect the amount of oxygen given to ICU patients on high-flow nasal oxygen therapy. Researchers will test two different monitors and two oxygen targets in 30 adults. The goal is to see which combinati…

This study looks at how changing the pressure inside the lungs (called PEEP) affects how hard patients have to work to breathe while on a ventilator. Twelve adults in the ICU who are already breathing with some help from a machine will have their PEEP set to four different levels…

This study follows 235 adults who survived acute respiratory failure (ARF) and their family caregivers. Over 6 months, they complete surveys about their expectations, mood, and coping. The goal is to see if positive or negative expectations are linked to anxiety, depression, and …

This study compares two ways to place a breathing tube in emergency patients who are still breathing on their own but need help. The methods are Rapid Sequence Intubation (RSI) and Delayed Sequence Intubation (DSI). Researchers will measure oxygen levels, complications, and survi…

This study looks at whether measuring oxygen levels on a facemask is reliable for critically ill patients who need a breathing tube. Doctors usually rely on pulse oximetry, but that can be misleading. The researchers will compare facemask readings with a more accurate pharyngeal …

This study uses a non-invasive imaging technique called electrical impedance tomography to watch how air moves through the lungs of children with acute respiratory failure in the pediatric ICU. Researchers will observe how changes in ventilator settings, body position, suctioning…

This study observes 325 adults with acute breathing failure who are using non-invasive breathing support like high-flow oxygen or a mask ventilator. Researchers want to find out which patients end up needing a breathing tube. The goal is to better predict and prevent treatment fa…

This study looks back at medical records of about 59 ICU patients who used a low-flow carbon dioxide removal (ECCO2R) machine for breathing failure. The goal is to describe how the device was used and what happened to patients, including survival and side effects. It does not tes…

This study compares two types of video laryngoscope blades—hyperangulated and Macintosh—to see which leads to successful intubation on the first try in ICU patients. Over 1,000 adults needing a breathing tube will be randomly assigned to one blade type. The goal is to find out if…