ACUTE RESPIRATORY FAILURE

This study tests whether giving steroids based on a patient's immune status can improve survival in severe pneumonia with breathing failure. About 500 ICU adults will receive standard care plus tailored steroids. The goal is to find who benefits most and reduce side effects.

This study looks at whether reducing immunosuppressive medications can help kidney transplant patients recover from life-threatening infections in the intensive care unit. About 212 adult kidney transplant recipients who are admitted to the ICU with septic shock or severe breathi…

This study tests a new imaging technique called electrical impedance tomography (EIT) to measure how air and blood flow in the lungs of children with acute breathing failure. The study will include 20 children under 12 years old who are on a breathing machine. The goal is to see …

This study looks at whether giving each patient on a breathing machine a personalized oxygen target—based on their own health data—leads to better outcomes than the usual one-size-fits-all approach. About 3,000 critically ill adults will take part. The goal is to see if this tail…

This study looks at whether a simple, non-invasive ultrasound of the diaphragm can help predict which older adults (75+) will develop severe breathing problems after arriving at the emergency room with shortness of breath. Researchers will measure diaphragm movement and thickness…

This study will collect information from 1,200 patients in the French West Indies and Guiana who receive ECMO, a machine that helps the heart and lungs work. The goal is to learn how well ECMO works and what problems may occur. No new treatments are being tested; instead, researc…